Preparation method and use of ginkgo-leaf extract

A technology for ginkgo biloba leaves and extracts, which is applied in the field of preparation of ginkgo biloba extracts, can solve problems such as affecting product quality, low extraction rate, difficulty, etc. Effect

Inactive Publication Date: 2009-05-06
曹阳春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the steam distillation method has a low extraction rate due to the poor selectivity of water to the active ingredients; the residue of the organic solvent in the product in the solvent extraction method will affect the product quality, and the safety is poor; the supercritical fluid extraction method is due to Large equipment and difficult operation a

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 5 kg of fresh ginkgo leaves, bake them in an oven at 65°C for 9 hours, take them out and cool them to room temperature, crush them with a pulverizer, and pass them through a 60-mesh sieve. Weigh 2 kg into the extraction kettle, add 30 L of 75% ethanol to soak, and use an ultrasonic cell pulverizer to vibrate at 400-500 times / min for 6 seconds with an interval of 7 seconds, a total of 50 times. Then raise the temperature to 65°C, extract for 2 hours, filter with suction and retain the filtrate, then extract the filter residue with an equivalent amount of 75% ethanol at 65°C for 2 hours, combine the two filtrates after suction filtration, separate and discard the precipitate in a centrifuge to obtain a sample stock solution . Further vacuum concentration at a vacuum degree of 0.09Mpa and a temperature of 60° C. to obtain a sample concentrate, which was dried in vacuum to constant weight to obtain a ginkgo biloba extract extract. The extraction rate of the extract re...

Embodiment 2

[0017] Except that the extraction temperature is 75°C, the solid-to-liquid ratio is 1:20, and the extraction time is 2 hours, the other conditions are the same as in Example 1, and the extraction rate of the extract reaches 35.44%, wherein the flavonoid content is 34%, and the lactone The quasi-substance content is 9%.

Embodiment 3

[0019] After the prepared Ginkgo biloba extract was added to the feed at 4g / kg, it had a significant growth-promoting effect on meat ducks, and at the same time significantly increased the AIH of meat ducks. 5 Antibody levels.

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PUM

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Abstract

The invention discloses a preparation method and an application of a ginkgo leaf extract, wherein the method comprises the following steps of: a) washing and then drying ginkgo leaves; b) crashing and sieving; c) soaking by ethanol; d) oscillating by a ultrasonic cell crasher; e) extracting and filtering; and f) condensing in vacuum and drying. The invention has the advantages of adopting an ultrasonic-assisted extraction method, utilizing the functions of strong vibration, extremely high acceleration, strong cultivation effect, even stirring and the like generated by ultrasonic waves, accelerating the entry of the medicament effective constituents into the solvent, simultaneously avoiding the effect of high temperature on extraction constituents and greatly improving the yield of the extract. In the extract, flavonoids accounts for 36 percent, ginkgo terpene lactones account for over 8 percent while the injurant phenolic acid is less than 3PPM, therefore, the product has high safety. The obtained Ginkgo leaf extract of 4 to 6g is added to each kilogram of feeding stuff, therefore, the animal immune anti-inflammatory action and the production property can be raised by more than 10 percent and 2 to 3 percent respectively.

Description

technical field [0001] The invention relates to a preparation method and application of ultrasonic-assisted ginkgo leaf extract with fast extraction speed, high extraction rate, solvent and energy saving. Background technique [0002] In recent years, the efficacy of Ginkgo biloba extract has attracted more and more people's attention. It can improve the production performance of livestock and poultry, increase the speed of weight gain, improve the feed conversion rate, increase the immune organ index of livestock and poultry, and reduce the blood lipid level of livestock and poultry. . Ginkgo biloba extract has a wide variety of extraction processes, mainly steam distillation, solvent extraction, supercritical fluid extraction, ultrasonic-assisted extraction, enzymatic and microwave methods. Among them, the steam distillation method has a low extraction rate due to the poor selectivity of water to the active ingredients; the residue of the organic solvent in the product in...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61P29/00A61P37/04A23K1/16A61K127/00A23K10/30
Inventor 曹阳春陈伟张瑞霞
Owner 曹阳春
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