Technique for manufacturing anhydrous medicinal mirabilite

Abstract

The invention relates to a technique for manufacturing anhydrous medicinal mirabilite. The method comprises the following steps: under the monitoring of an on-line infrared computer automatic monitoring system and the regulation and control of a porous plate liquid balance flowmeter, when the indoor air cleanliness of a production shop achieves a certain index, removing mechanical impurities from original nitrate solution (transported underground) with a certain concentration through a pipeline filter, purifying by ion exchange to obtain fine nitrate solution with low content of metallic ion impurities, inputting the fine nitrate solution into a continuous crystallization system, carrying out continuous solid-liquid separation on the crystallized crystal slurry through a strap type centrifugal machine to obtain medicinal mirabilite crystals, melting the medicinal mirabilite crystals in a steam heating or electric heating mode, carrying out solid-liquid separation, respectively drying solid and liquid with hot air to obtain the anhydrous medicinal mirabilite, and finally, carrying out aseptic packaging by using an automatic packaging system. On the premise of ensuring high product purity and conformity to GMP requirements, the invention has more ideal unit productivity.

Description

Technical field: [0001] The invention belongs to the processing field of pharmaceutical chemicals. Background technique: [0002] Anhydrous sodium sulfate is also called anhydrous nitrate, anhydrous Glauber's salt, Yuanming powder, Xuanming powder; white fine-grained crystal or powder, easily soluble in water, hygroscopic, odorless, non-toxic, medicinal Glauber's salt is mainly crystal form used in the field of medicine. [0003] Introduced in the Chinese patent No. CN101041444A the method for separating Glauber's salt (sodium sulfate) by frozen crystallization in saline solution, it is through adjusting pH value with 3-5% sulfuric acid solution, precooling, control crystallization temperature at 0-10 ℃, separation, Recrystallized to make a finished product. The technological process adopted in this method is actually to make saltwater into Glauber's salt containing crystal water first, then remove the free water in Glauber's salt, and finally obtain the production process...

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Problems solved by technology

The technological process adopted in this method is actually to make saltwater into Glauber's salt containing crystal water first, then remove the free water in Glauber's salt, and finally obtain the production process of Glauber's salt containing crystal water; Glauber's salt has high energy consumption and the purity of Glauber's salt is not high, and it is not conducive to large-scale production

[0004] In China Patent No. 97116654.4, a production method of frozen crystallization to produce Glauber's salt containing crystal water is introduced. It goes through technological processes such as dehalogenation, concentration, beach drying, collection, and impurity removal. The method mainly adopts the method of cooling, concentration, and drying , and the temperature is controlled at 18°C ​​in hot days and 10°C in winter and spring. The purpose is to produce Glauber's salt containing crystal water by crystallization in this way. However, the purity of Glauber's salt produced in this way is not high, and it requires a large harvesting site. factor, and at the same time, it is very unlikely to produce hundreds of thousands of tons of

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