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Self-emulsifying brucea javanica oil oral preparation composition and preparation method thereof

A technology of javanica javanica oil and oral preparations, applied in the direction of drug combination, medical preparations containing active ingredients, digestive system, etc., can solve the problem of reducing the stimulation effect of drugs on the gastrointestinal tract, with less drug content, and can not further cover up the bad smell of drugs and other problems, to achieve the effect of improving bioavailability, rapid absorption, and low viscosity

Inactive Publication Date: 2011-02-23
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantage of the system is that the drug content is small, and there is an aqueous phase in the system, which cannot further cover up the bad smell of the drug and reduce the stimulating effect of the drug on the gastrointestinal tract.

Method used

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  • Self-emulsifying brucea javanica oil oral preparation composition and preparation method thereof
  • Self-emulsifying brucea javanica oil oral preparation composition and preparation method thereof
  • Self-emulsifying brucea javanica oil oral preparation composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The components and weight percentages of the self-microemulsifying composition of this embodiment are: Brucea javanica oil 30%, mixed emulsifier 62%, co-emulsifier 8%.

[0020] The emulsifier is polyoxyethylene hydrogenated castor oil and polyglycerin fatty acid ester.

[0021] Described co-emulsifier is glycerol.

[0022] The preparation process of the self-microemulsifying composition in the present embodiment is: measure polyoxyethylene hydrogenated castor oil and polyglycerol fatty acid ester of recipe quantity and add glycerol and mix, vortex mix; Measure javanica javanica oil (37 ±1) °C constant temperature water bath for 10 minutes. Add the drug dropwise while stirring to mix the emulsion, and vortex for 30 seconds. (37±1)℃ constant temperature water bath for 30min.

[0023] The beneficial effects of this embodiment are: (1) after diluting the prepared self-microemulsified composition 100 times, the measured average particle diameter is 35.2nm, and the particl...

Embodiment 2

[0025] The components and weight percentages of the self-microemulsifying composition of the present embodiment are: Brucea javanica oil 17.5%, emulsifier 45%, co-emulsifier 20%, grease 17.5%.

[0026] Described emulsifier is polyoxyethylene castor oil.

[0027] Described co-emulsifier is propylene glycol.

[0028] Described grease is oleic acid.

[0029] The preparation process of the self-microemulsifying composition in this example is: take the polyoxyethylene castor oil of prescription quantity and add propylene glycol to mix, vortex mix; Take oleic acid and add javanica javanica oil (37 ± 1) ℃ constant temperature water bath 10min. Add the drug dropwise while stirring to mix the emulsion, and vortex for 30 seconds. (37±1)℃ constant temperature water bath for 30min.

[0030] The beneficial effects of this embodiment are: (1) After diluting the prepared self-microemulsion composition 100 times, the measured average particle size is 50.76nm, and the particle size is less...

Embodiment 3

[0032] The components and weight percentages of the self-microemulsifying composition of the present embodiment are: Brucea javanica oil 9%, emulsifier 55%, mixed co-emulsifier 18%, and oil 18%.

[0033] Described emulsifier is polyoxyethylene castor oil.

[0034] Described co-emulsifier is ethanol and polyethylene glycol 400.

[0035] Described grease is castor oil.

[0036] The preparation process of the self-microemulsifying composition in the present embodiment is: measure the polyoxyethylene castor oil of prescription quantity and add ethanol and polyethylene glycol 400 to mix, vortex mix; Measure castor oil and add javanica javanica oil (37 ±1) °C constant temperature water bath for 10 minutes. Add the drug dropwise while stirring to mix the emulsion, and vortex for 30 seconds. (37±1)℃ constant temperature water bath for 30min.

[0037] The beneficial effects of this embodiment are: (1) After diluting the prepared self-microemulsion composition 100 times, the measure...

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Abstract

The invention relates to the technical field of medicament preparations, in particular to a self-emulsifying brucea javanica oil oral preparation composition and a preparation method thereof. The composition comprises the following components in percentage by mass: 9 to 35 percent of brucea javanica oil, 45 to 62 percent of emulsifier, 2 to 20 percent of auxiliary emulsifier and 0 to 18 percent of fatty oil. In the method, special equipment is not used, preparation operation is simple, and the obtained composite has a grain size of 10 to 100nm and is easy to store.

Description

technical field [0001] The invention relates to a mixture and a method in the technical field of medicine preparation, in particular to a self-microemulsible oral preparation composition of javanica javanica oil and a preparation method thereof. Background technique [0002] Brucea javanica is the fruit of the bitter wood plant plant. Cold in nature, bitter in taste, slightly poisonous. Can clear heat and detoxify, cut off malaria, stop dysentery, corrode warts. It contains alkaloids, glycosides, phenolic components and hydroxycarboxylic acids. The oleic acid, linoleic acid and other related components contained in javanica javanica oil have a specific affinity with tumor cells and have strong anticancer activity. The vegetable oil has the characteristics of improving the body's immunity and protecting bone marrow hematopoietic stem cells when it is anti-tumor. Compared with commonly used chemotherapeutic drugs, it has certain advantages. At present, its dosage forms in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P35/00A61K9/48A61P1/04A61K9/107A61P1/00A61K131/00A61P31/20A61K36/185
Inventor 沈琦王颖李盈
Owner SHANGHAI JIAO TONG UNIV
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