Preparation method of three-phase CaP-glass coating/porous A1203 rack biological composite material

A composite material and glass coating technology, applied in coatings, medical science, prostheses, etc., can solve problems such as low bonding strength, poor dissolution rate and biological activity of sintered HA, and difficult replacement of hard tissues

Inactive Publication Date: 2011-03-30
SHAANXI UNIV OF SCI & TECH
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that in porous Al 2 o 3 Coating HA coating on the stent can get a coating with a thickness of 20-30μm, however, the morphology of the coating is microporous, and the bonding strength is less than 25MPa
If the bonding between the coating and the substrate is poor, hard tissue replacement becomes difficult, and the dissolution rate and bioactivity of sintered HA are poor compared to real human bone

Method used

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  • Preparation method of three-phase CaP-glass coating/porous A1203 rack biological composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] (1) Preparation of triple-phase glass: xCaO·(0.55-x)Na according to the composition formula 2 O 0.45P 2 o 5 , where x is 0.1, and P 2 o 5 , NaH 2 PO 4 and CaCO 3 , sintered at 1100°C for 1h to melt;

[0016] (2) quenching, grinding and sieving the molten glass obtained in step (1) successively to obtain glass powder with a particle size less than 20 μm;

[0017] (3) The glass powder obtained in step (2) and hydroxyapatite (hydroxyapatite, HA) were mixed in ethanol, and ball milled for 24 hours to obtain a mixed slurry, wherein the glass powder accounted for the glass powder and hydroxyapatite 5% of the total mass of stone;

[0018] (4) Preparation of porous Al by impregnation method 2 o 3 scaffold, then in porous Al 2 o 3 The mixed slurry obtained in step (3) is coated on the support by a dip-rotation process, so as to obtain a composite coating;

[0019] (5) After the composite coating is dried, the porous Al 2 o 3 The scaffold was heated to 700°C at a r...

Embodiment 2

[0021] (1) Preparation of triple-phase glass: xCaO·(0.55-x)Na according to the composition formula 2 O 0.45P 2 o 5 , where x is 0.2, and P 2 o 5 , NaH 2 PO 4 and CaCO 3 , sintered at 1250°C for 1h to melt;

[0022] (2) quenching, grinding and sieving the molten glass obtained in step (1) successively to obtain glass powder with a particle size less than 20 μm;

[0023] (3) The glass powder obtained in step (2) and hydroxyapatite (hydroxyapatite, HA) were mixed in ethanol, and ball milled for 24 hours to obtain a mixed slurry, wherein the glass powder accounted for the glass powder and hydroxyapatite 50% of the total mass of stone;

[0024] (4) Preparation of porous Al by impregnation method 2 o 3 scaffold, then in porous Al 2 o 3 The mixed slurry obtained in step (3) is coated on the support by a dip-rotation process, so as to obtain a composite coating;

[0025] (5) After the composite coating is dried, the porous Al 2 o 3 The scaffold was heated to 700°C at a ...

Embodiment 3

[0027] (1) Preparation of triple-phase glass: xCaO·(0.55-x)Na according to the composition formula 2 O 0.45P 2 o 5 , where x is 0.3, and P 2 o 5 , NaH 2 PO 4 and CaCO 3 , sintered at 1150°C for 1h to melt;

[0028] (2) quenching, grinding and sieving the molten glass obtained in step (1) successively to obtain glass powder with a particle size less than 20 μm;

[0029] (3) The glass powder obtained in step (2) and hydroxyapatite (hydroxyapatite, HA) were mixed in ethanol, and ball milled for 24 hours to obtain a mixed slurry, wherein the glass powder accounted for the glass powder and hydroxyapatite 15% of the total mass of stone;

[0030] (4) Preparation of porous Al by impregnation method 2 o 3 scaffold, then in porous Al 2 o 3 The mixed slurry obtained in step (3) is coated on the support by a dip-rotation process, so as to obtain a composite coating;

[0031] (5) After the composite coating is dried, the porous Al 2 o 3 The scaffold was heated to 700°C at a ...

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Abstract

The invention provides a preparation method of a three-phase CaP-glass coating/porous A1203 rack biological composite material, which belongs to the technical field of biological medicinal material preparation and comprises the following steps of: coating a composite coating consisting of biological glass using HA (Hydroxylapatite) and phosphate as base bodies on a porous Al2O3 rack to obtain the combination of good biological performance and mechanical performance; mixing HA powder and biological glass powder with different compositions at different proportions to obtain slurry to be coated on the porous Al2O3 rack; carrying out heat treatment for two hours in air at 800 DEG C; and forming the three-phase CaP-glass coating through generating hydroxylapatite (HA), tertiary calcium phosphate (TCP) and calcium hydrophosphate (DCP) principal crystalline phases in the coating phase. The three-phase CaP-glass coating is tightly, uniformly and closely attached on the Al2O3 rack, the highest combining intensity of the three-phase CaP-glass coating can reach 50MPa and is more than two times of that of the pure HA coating, the growth of the osteoblast on the porous Al2O3 rack coated with the three-phase CaP-glass coating is good, and cells can actively pass the coating to be spread into the porous rack.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, and relates to a three-phase CaP-glass coating / porous Al 2 o 3 Preparation method of scaffold biocomposite. Background technique [0002] Hydroxyapatite (hydroxyapatite, HA) is the main component (60-70%) of the human body's natural bone, and has excellent biological activity and guidance for bone tissue growth. Therefore, it has aroused great interest in bone replacement. Clinical trials have shown that HA has the ability to directly combine with bone and complete osteoconductivity. However, poor mechanical properties, such as strength and fracture toughness, limit its application in hard tissue replacement. [0003] A coating-substrate system, such as ZrO 2 , Al 2 o 3 , Ti and its alloys as the matrix, and HA as the coating can obtain a good combination of mechanical properties and biological properties. Studies have shown that in porous Al 2 o 3 The HA coa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/02C03C12/00
Inventor 王莉丽王秀峰于成龙江红涛
Owner SHAANXI UNIV OF SCI & TECH
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