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Liquiritin and preparation method thereof

A technology of liquiritin and glycyrrhizic acid, which is applied in the field of medicine to achieve the effects of low production cost, easy standardization, and easy promotion

Inactive Publication Date: 2011-05-11
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention is novel in technology, easy to operate, energy-saving and environment-friendly, and has good practicability. At present, there is no relevant patent or literature report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 50Kg of glycyrrhizic acid powder, add 200L of 0.5% dilute ammonia water, heat and extract at 60°C for 2 hours, filter, add 100L of n-butanol to the filtrate to extract twice, and concentrate the upper extract under reduced pressure at 80°C to obtain total flavonoids of licorice Extract 6.12Kg;

[0024] Take 6.12Kg of the above licorice total flavonoid extract, add 61.2L of water, stir, dissolve, filter, put the filtrate on a 100-200 mesh polyamide column, after the column is completed, first elute with 124L of water to remove large polar impurities, and then Elute with 124L of 20% dilute ethanol, collect the eluate and concentrate it under reduced pressure at 80°C to 12.4L, filter, and place the filtrate to crystallize at 8°C for 24 hours, filter to obtain 521g of crude liquiritin; take the above-mentioned liquiritin Add 2L of absolute ethanol to dissolve 521g of crude product at 78°C, filter, and place the filtrate to crystallize at 8°C for 24 hours, filter, and d...

Embodiment 2

[0027] Take 100Kg of glycyrrhizic acid powder, add 400L of 1% dilute ammonia water, heat and extract at 60°C for 2 hours, filter, add 200L of n-butanol to the filtrate to extract twice, and concentrate the upper extract under reduced pressure at 80°C to obtain total flavonoids of licorice Extract 12.16Kg;

[0028] Take 12.16Kg of the above licorice total flavonoid extract, add 182.4L of water, stir, dissolve, filter, put the filtrate on a 100-200 mesh polyamide column, after the column is loaded, first elute with 364.8L of water to remove the large polar impurities, Then elute with 121.6L of 10% dilute ethanol, collect the eluate and concentrate it under reduced pressure at 60°C to 7.5L, filter, and place the filtrate to crystallize at 8°C for 12 hours, filter to obtain 985g of crude liquiritin; Add 985g of crude liquiritin, add 3.26L of 95% ethanol, heat to dissolve, filter, place the filtrate at 8°C for crystallization for 36 hours, filter, and dry to obtain 781g of liquirit...

Embodiment 3

[0031] Take 30Kg of glycyrrhizic acid powder, add 90L of 0.5% dilute ammonia water, heat and extract at 80°C for 1 hour, filter, add 60L of ethyl acetate to the filtrate to extract 3 times, and concentrate the upper extract under reduced pressure at 60°C to obtain total flavonoids of licorice Extract 3.7Kg;

[0032] Take 3.7Kg of the above licorice total flavonoid extract, add 18.5L of water, stir, dissolve, filter, put the filtrate on a 100-200 mesh polyamide column, after the column is completed, first elute with 74L of water to remove large polar impurities, and then Elute with 74L of 20% dilute ethanol, concentrate the eluent at 80°C to 7.4L under reduced pressure, filter, place the filtrate to crystallize at 8°C for 12 hours, and filter to obtain 247g of crude liquiritin; take 247g of the above crude liquiritin , add 0.5L of 95% ethanol, heat to dissolve, filter, and place the filtrate at 15°C for crystallization for 12 hours, filter, and dry to obtain 209g of liquiritin;...

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Abstract

The invention relates to high-purity liquiritin prepared from glycyrrhizic acid powder and a preparation method thereof, and the method comprises the following main steps: taking the glycyrrhizic acid powder, adding an appropriate amount of dilute ammonia water for dissolution, filtering, adding an appropriate amount of organic solvent for extraction, concentrating the upper layer of an extraction liquid and getting a liquid extract of total flavonoids of liquoric root; taking the liquid extract of the total flavonoids of the liquoric root, adding an appropriate amount of water, stirring, dissolving, filtering, enabling a filtrate to pass through a polyamide column, firstly using an appropriate amount of water for eluting and removing water-soluble impurities, further using an alcohol solution with a certain concentration for eluting, collecting the eluate, performing vacuum concentration, placing, crystallizing, and getting a crude product of the liquiritin; taking the crude product of the liquiritin, adding an appropriate amount of solvent, dissolving, filtering, placing, crystallizing, filtering, drying, and getting the high-purity liquiritin; and adopting the high-performance liquid phase chromatography for determination, wherein the content range of the liquiritin is 80-95%. The liquiritin produced through the technical scheme provided by the invention has high purity, low cost, stable and controllable quality, and low requirement on equipment and is applicable to industrial production.

Description

technical field [0001] The invention relates to a high-purity liquiritin prepared from glycyrrhizic acid coarse powder and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Licorice is the roots and rhizomes of Glycyrrhiza Linn. plants of the leguminosae family Glycyrrhiza Linn. Ural, Glycyrrhiza glabra, and Glycyrrhiza inflate, which are distributed all over the world. Licorice has a long history of being used as medicine. "Shen Nong's Materia Medica" listed it as the best medicine, and ancient medical scientists honored it as "the old man of the country". Because of its precious resources, it is listed as the second-class national protected wild medicinal material by the country. There are many kinds of chemical components in licorice, mainly containing triterpenoid saponins, flavonoids, alkaloids, polysaccharides and other components. There are many preparations developed with licorice as medicine, which have been widely use...

Claims

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Application Information

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IPC IPC(8): C07H15/26C07H1/06
Inventor 金显友袁红波杨永安季浩
Owner JIANGSU TIANSHENG PHARMA
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