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Aspirin lysine dispersible tablet and preparation method thereof

A technology of lysine-pirin and dispersible tablets, which is applied in the field of pharmaceutical preparations, can solve the problems that it is difficult to quickly exert a therapeutic effect, affect the stability of lysine-pirin, and patients cannot self-administer drugs, so as to achieve convenience in carrying and taking, and improve compliance Sexuality, the effect of reducing the probability of occurrence

Inactive Publication Date: 2011-06-01
蚌埠丰原涂山制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the administration by injection has a quick effect, patients cannot self-administer it, which brings inconvenience to clinical use and also poses safety risks
The capsule dosage form of lysine is easy to absorb the moisture in the capsule shell, which affects the stability of lysine
Oral administration of large-scale lysine-pirin capsules and ordinary lysine-pirin tablets is difficult, requiring multiple doses, and it is difficult to quickly exert a therapeutic effect

Method used

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  • Aspirin lysine dispersible tablet and preparation method thereof
  • Aspirin lysine dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] 1. Raw drug formula (by weight):

[0014] Lysine pyrin 0.25, microcrystalline cellulose 0.1, croscarmellose sodium 0.1, stevia 0.05, pineapple flavor 0.01, hypromellose 0.01, talc 0.1.

[0015] 2. The preparation method consists of the following steps:

[0016] (1) Pretreatment and weighing of raw and auxiliary materials: pulverize lysine and each auxiliary material, pass through an 80-mesh sieve, and weigh according to the prescription for future use;

[0017] (2) Mixing: mix the above-mentioned raw and auxiliary materials evenly;

[0018] (3) Tablet compression: use a tablet press machine, select a suitable die for dry compression;

[0019] (4) Packaging.

Embodiment 2

[0021] 1. Raw drug formula (by weight):

[0022] Lysine 0.25, pregelatinized starch 0.1, hydroxypropyl cellulose 0.5, stevia 0.02, banana flavor 0.02, polyvinylpyrrolidone 0.02, micronized silica gel 0.1.

[0023] 2. The preparation method consists of the following steps:

[0024] (1) Pretreatment and weighing of raw and auxiliary materials: pulverize lysine and each auxiliary material, pass through an 80-mesh sieve, and weigh according to the prescription for future use;

[0025] (2) Mixing: mix the above-mentioned raw and auxiliary materials evenly;

[0026] (3) Tablet compression: use a tablet press machine, select a suitable die for dry compression;

[0027] (4) Packaging.

Embodiment 3

[0029] 1. Raw drug formula (by weight):

[0030] Lysine 0.25, lactose 0.1, hydroxypropyl cellulose 0.1, saccharin sodium 0.01, orange flavor 0.01, polyvinylpyrrolidone 0.2, talcum powder 5g.

[0031] 2. The preparation method consists of the following steps:

[0032] (1) Pretreatment and weighing of raw and auxiliary materials: pulverize lysine and each auxiliary material, pass through an 80-mesh sieve, and weigh according to the prescription for future use;

[0033] (2) Mixing: mix the above-mentioned raw and auxiliary materials evenly;

[0034] (3) Tablet compression: use a tablet press machine, select a suitable die for dry compression;

[0035] (4) Packaging.

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Abstract

The invention provides a novel aspirin lysine dispersible tablet, which is prepared from the raw drugs in parts by weight: 0.25-1 of aspirin lysine, 0.1-10 of filling agent, 0.1-10 of disintegrating agent, 0.01-0.5 of flavoring agents, 0.01-0.2 of adhesives, 0.1-5 of fluidizers and 0.01-1 of essences. The invention also provides a preparation method of the novel aspirin lysine dispersible tablet. The aspirin dispersible tablet provided by the invention quickly disintegrates and releases when contacting with the water so as to form a sweet-taste solution, and the solution can be orally taken directly or taken after dissolving with the water. The novel aspirin lysine dispersible tablet solves the problems of easiness of degradation of free salicylic acid in aspirin lysine, improves the stability of aspirin lysine medicines, is convenient for carrying and taking, is suitable for patients who are difficult to swallow, and also can be orally taken directly (small specification of tablets), in particular to children, thereby the compliance of taking the medicine can be improved.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a lysine-pirin dispersible tablet and a preparation method thereof. Background technique [0002] Lyspirin is a double salt of aspirin and lysine, which belongs to non-steroidal anti-inflammatory drugs, can inhibit cyclooxygenase, reduce the synthesis of prostaglandins, and has antipyretic, analgesic and anti-inflammatory effects. In 1970, lysine was first developed and launched by the French company egic. At present, it is listed in Europe, South Africa, Asia and other countries. Internationally important manufacturers include Sanofi-Aventis of France and Bayer of Germany. The trade names are aspegic and aspisol respectively. Domestic manufacturers mainly include Jilin Mayinglong, Anhui Fengyuan Tushan Pharmaceutical, etc. The clinical dosage form of lysine-pirin medicine mainly contains powder, powder injection, capsule etc. at present, and route of administration is oral admin...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/616A61K31/198A61P29/00
Inventor 李保琴张勇尹群
Owner 蚌埠丰原涂山制药有限公司
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