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Nasal composition containing povidone iodine and cyclodextrin inclusion of glucocorticoid

A technology of glucocorticoids and povidone-iodine, which is applied in the field of nasal pharmaceutical compositions, can solve problems affecting the stability of preparations, and achieve the effects of avoiding adverse reactions, improving stability, and good therapeutic effects

Inactive Publication Date: 2011-06-01
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent application 200780008873.5 discloses an ophthalmic composition containing povidone-iodine. In this application, the technical scheme that the povidone-iodine content is 0.5% to 2% and the corticosteroid content is 0.005% to 0.02% is preferred, but It is also pointed out in the application that too high or too low povidone-iodine content will affect the stability of the preparation, so when preparing a compound preparation containing povidone-iodine, maintaining the stability of the preparation becomes an important problem to be faced

Method used

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  • Nasal composition containing povidone iodine and cyclodextrin inclusion of glucocorticoid
  • Nasal composition containing povidone iodine and cyclodextrin inclusion of glucocorticoid
  • Nasal composition containing povidone iodine and cyclodextrin inclusion of glucocorticoid

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Experimental program
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Effect test

Embodiment 1

[0034] Embodiment 1, the preparation of hydrocortisone cyclodextrin inclusion aqueous solution

[0035] Dissolve 10g of 3-hydroxypropyl-β cyclodextrin in 75ml of 95% ethanol at room temperature, add 1g of hydrocortisone, stir to dissolve, stir for another 30 minutes, filter through a microporous membrane (220nm), add 40ml of Water for injection, stirred for 5 minutes, concentrated under reduced pressure, and evaporated to remove ethanol to obtain an aqueous solution of hydrocortisone / 3-hydroxypropyl-β-cyclodextrin inclusion complex for future use.

Embodiment 2

[0036] Embodiment 2, preparation of dexamethasone inclusion aqueous solution

[0037] Dissolve 40g of hydroxyethyl-β-cyclodextrin in 100ml of acetone at room temperature, add 1g of dexamethasone, stir to dissolve, stir for another 30 minutes, filter through a microporous membrane (220nm), add 10mL of water for injection, stir for 5 Minutes, concentrated under reduced pressure, distilled off acetone to obtain dexamethasone / hydroxyethyl-β-cyclodextrin inclusion aqueous solution, set aside.

Embodiment 3

[0038] Embodiment 3, the preparation of mometasone furoate cyclodextrin inclusion aqueous solution

[0039] Dissolve 4g of 2-hydroxypropyl-β-cyclodextrin in 20ml of acetone at 40±2°C, add 1g of mometasone furoate, stir to dissolve, stir for another 30 minutes, filter through a microporous membrane (220nm), add 6mL water for injection, stirred for 5 minutes, and concentrated under reduced pressure. The concentration process was added twice, adding 8ml water for injection each time, and acetone was removed to obtain mometasone furoate / 2-hydroxypropyl-β-cyclodextrin inclusion aqueous solution ,spare.

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Abstract

A nasal composition containing povidone iodine and cyclodextrin inclusion of glucocorticoid comprises povidone iodine and glucocorticoid as active components, and one or several accessories which are suitable for nasal drug administration. The nasal composition is characterized in that the glucocorticoid is included by beta-cyclodextrin or its derivatives, and the povidone iodine content in the nasal composition is 0.5%-5%.

Description

Technical field: [0001] The invention relates to a nasal pharmaceutical composition with povidone iodine and glucocorticoid as active ingredients. Background technique: [0002] Rhinitis is a common disease, mainly divided into several types such as acute rhinitis, chronic rhinitis and allergic rhinitis. Among them, acute rhinitis is acute inflammation of nasal mucosa, mainly caused by viral infection, and often secondary bacterial infection; chronic rhinitis is often caused by The development of acute rhinitis is related to the secondary infection of bacteria, incomplete treatment and repeated attacks; allergic rhinitis is caused by the high sensitivity of the nasal mucosa to certain allergens in the inhaled air. The allergens mainly include the following: Substance: [0003] (1) Inhalational allergens: such as indoor and outdoor dust, dust mites, fungi, animal fur, feathers, cotton wadding, etc., often cause perennial attacks; plant pollen causes mostly seasonal attacks; ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/79A61K47/48A61K31/58A61P11/02A61K47/69
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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