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Method for synthesizing mesoporous silica-based nanocomposite embedded with gold nanorods

A technology of nanocomposite materials and gold nanorods, which is applied in the synthesis field of mesoporous silicon-based nanocomposites, can solve the problems of high biological toxicity and achieve the effects of ensuring dispersion, solving biological toxicity and ensuring functionalization

Inactive Publication Date: 2012-05-30
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to synthesize a monodisperse, stable mesoporous silicon-based nanoparticle and gold nanorod composite structure nanomaterial, that is, a mesoporous silicon-based nanocomposite material inlaid with gold nanorods, so as to overcome the problem of adsorbing the particle surface in the prior art. Problems such as high biological toxicity caused by surfactants and reaction auxiliary catalyst residues

Method used

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  • Method for synthesizing mesoporous silica-based nanocomposite embedded with gold nanorods
  • Method for synthesizing mesoporous silica-based nanocomposite embedded with gold nanorods
  • Method for synthesizing mesoporous silica-based nanocomposite embedded with gold nanorods

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Experimental program
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Effect test

Embodiment 1

[0040] (1) Carboxyl functional modification of gold nanorods: using cetyltrimethylammonium bromide (CTAB) as a dispersant and growth-directing agent to synthesize 20ml of gold nanorod sol aqueous solution with a gold element concentration of 3.75mmol / L . Add 2 mg / ml of HOOC-(CH 2 CH 2 O) 7 -S-S-(CH 2 CH 2 O) 7 -COOH (CAS Number: 873013-93-5) compound aqueous solution 10ml, then ultrasonicated at 55° C. for 2 hours to obtain carboxyl-functionalized gold nanorod solution.

[0041] (2) Surface amino functionalization of mesoporous silicon-based nanoparticles: mesoporous silica nanoparticles (Fe 3 o 4 mSiO 2 ) 20mg is dispersed in 30ml ethanol, and the added aminotriethoxysilane is 1 / 50 of the molar weight of mesoporous silicon-based nanoparticles, and Fe 3 o 4 mSiO 2 Carry out modification, heat and reflux for 5 hours, centrifuge the obtained reflux product, and disperse in water to obtain 10 ml of an aqueous solution of mesoporous silicon-based nanoparticles functiona...

Embodiment 2

[0054] The magnetic mesoporous silicon-based nanocomposite inlaid with gold nanorods obtained in Example 1 was ultrasonically dispersed in DMEM cell culture medium, and the concentration of the magnetic mesoporous silicon-based nanocomposite inlaid with gold nanorods in the DMEM cell culture medium solution was 80ug / ml, Transfer 100ul of the above solution to a 96-well plate. Use an 808nm desktop light source to irradiate the composite particle solution perpendicular to the 96-well plate, and adjust the irradiation power and time. After irradiation, measure the temperature of the solution in the hole with a digital display thermometer (configured with a stainless steel probe), and draw a temperature-time relationship curve (A).

Embodiment 3

[0063] (1) Carboxyl functional modification of gold nanorods: 20 ml of gold nanorod sol aqueous solution with a gold element concentration of 1 mmol / L was synthesized using cetyltrimethylammonium bromide (CTAB) as a dispersant and a growth-directing agent. Add 1 mg / ml of HOOC-(CH 2 CH 2 O) 7 -S-S-(CH 2 CH 2 O) 7 -COOH (CAS Number: 873013-93-5) compound was dissolved in 10 ml of water, and then ultrasonicated at 55° C. for 2 hours to obtain a carboxyl-functionalized gold nanorod solution.

[0064] (2) Surface amino functionalization of mesoporous silicon-based nanoparticles: mesoporous silica nanoparticles (Fe 3 o 4 mSiO 2 ) 50mg is dispersed in 30ml ethanol, and the added aminotriethoxysilane is 1 / 10 of the molar weight of mesoporous silicon-based nanoparticles, and Fe 3 o 4 mSiO 2 After modification, heating and reflux for 5 hours, the obtained reflux product was centrifuged and dispersed in water to obtain 10 ml of an aqueous solution of mesoporous silicon-based na...

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Abstract

The invention belongs to the field of nanobiological medicaments, and relates to a method for synthesizing a mesoporous silica-based nanocomposite embedded with gold nanorods. Based on the surface carboxyl-functionalization of gold nanorods and the surface amino-functionalization of mesoporous silica-based nanoparticles, the gold nanorods with carboxyl-functionalized surfaces and the mesoporous silica-based nanoparticles with amino-functionalized surfaces are compounded through an amide reaction to obtain the mesoporous silica-based nanocomposite with a uniform outer surface and the steadily embedded gold nanorods, wherein in the compound reaction, the synthesis is directly performed in water, a catalyst is not required to be added, and the acidity or ionic strength are not required to beadjusted. The method is simple and easy, pollution-free, and high in yield. The obtained composite has good dispersibility, biocompatibility and non-toxicity; and the composite possesses high medicament loading rate and medicament sustained-release function of mesoporous silica-based nanometer materials, and a function of the gold nano-rods which converts near infrared light into heat, can realize a therapeutic mode of the synergism of pharmacotherapy and optothermal therapy, and can be widely used in the fields of diagnosis and treatment of diseases, biological sterilization and the like.

Description

technical field [0001] The invention relates to a synthesis method of a mesoporous silicon-based nanocomposite material inlaid with gold nanorods, belonging to the field of nanobiological medicine. Background technique [0002] The combination of multiple treatment modes can play a synergistic effect, especially the synergistic treatment mode of hyperthermia and chemotherapy has been widely used in cancer treatment (Iternational Journal of Hyperthermia 2009, Vol.25, No.4, Pages 262-272) . However, the traditional hyperthermia mode cannot precisely control the heating area and power, the traditional chemotherapy drugs tend to kill normal cells and cause side effects, and it is impossible to ensure that heating and drugs act on the tumor at the same time and in the same area during coordinated treatment. The effect of synergistic treatment is significantly reduced, and has been limiting the development of this synergistic model. The application and development of nanomateria...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02A61K49/08A61N5/06A01N25/08A01P3/00
Inventor 马明陈航榕施剑林陈雨
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI