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Polypropylene/polyvinylidene fluoride composite hernia patch and preparation method thereof

A polyvinylidene fluoride, composite technology, applied in medical science, prosthesis, etc., to achieve the effect of high economic benefit, environmental friendliness, and simple operation

Inactive Publication Date: 2011-06-08
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide a polypropylene / polyvinylidene fluoride composite hernia patch and its preparation method. The hernia patch has a stable structure, good mechanical properties and biocompatibility; polyvinylidene fluoride Good anti-adhesion performance overcomes the problem that single-material polypropylene hernia mesh is easy to adhere to intestinal tissue; and the preparation method is simple and suitable for industrial production

Method used

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  • Polypropylene/polyvinylidene fluoride composite hernia patch and preparation method thereof
  • Polypropylene/polyvinylidene fluoride composite hernia patch and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] (1) Dissolving polyvinylidene fluoride in a dimethylformamide / acetone solution with a volume ratio of 8:2 to make a polyvinylidene fluoride solution with a concentration of 0.1 g / ml;

[0024] (2) Perform plasma modification on the polypropylene fiber braided layer under He atmosphere, the processing power is 100W, the time is 3min, and the air pressure is 15pa;

[0025] (3) Electrospin the polyvinylidene fluoride solution, place the modified polypropylene fiber braid on the receiving end, the flow rate is 0.2ml / h, the applied voltage value is 10kV, and the receiving distance is 13cm;

[0026] (4) After the electrospinning is finished, the composite fabric can be used for internal intestinal hernia repair surgery after being shaped, vacuum-dried and sterilized.

[0027] Wherein the obtained composite hernia patch has a thickness of 0.2mm.

Embodiment 2

[0029] (1) Dissolving polyvinylidene fluoride in a dimethylformamide / acetone solution with a volume ratio of 7:3 to make a polyvinylidene fluoride solution with a concentration of 0.3 g / ml;

[0030] (2) Perform plasma modification on the polypropylene fiber braided layer under He atmosphere, the processing power is 150W, the time is 2min, and the air pressure is 20pa;

[0031] (3) The polyvinylidene fluoride solution is electrospun, and the modified polypropylene fiber braid is placed on the receiving end, the flow rate is 0.25ml / h, the applied voltage value is 15kV, and the receiving distance is 15cm;

[0032] (4) After the electrospinning is finished, the composite fabric can be used for internal intestinal hernia repair surgery after being shaped, vacuum-dried and sterilized.

[0033] Wherein the obtained composite hernia patch has a thickness of 1mm.

Embodiment 3

[0035] (1) Dissolving polyvinylidene fluoride in a dimethylformamide / acetone solution with a volume ratio of 5:5 to make a polyvinylidene fluoride solution with a concentration of 0.25 g / ml;

[0036] (2) Perform plasma modification on the polypropylene fiber braided layer under He atmosphere, the processing power is 50W, the time is 2min, and the air pressure is 30pa;

[0037] (3) Electrospin the polyvinylidene fluoride solution, place the modified polypropylene fiber braid on the receiving end, the flow rate is 0.3ml / h, the applied voltage value is 8kV, and the receiving distance is 12cm;

[0038] (4) After the electrospinning is finished, the composite fabric can be used for internal intestinal hernia repair surgery after being shaped, vacuum-dried and sterilized.

[0039] Wherein the obtained composite hernia patch has a thickness of 3mm.

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Abstract

The invention relates to a polypropylene / polyvinylidene fluoride composite hernia patch and a preparation method thereof. The composite hernia patch has a bilayer structure, wherein the bottom layer is a plasma modified polypropylene braid and the surface layer is a polyvinylidene fluoride electrospinning film. The preparation method comprises the following steps: (1) dissolving polyvinylidene fluoride in the mixed solution of dimethylformamide and acetone to prepare polyvinylidene fluoride solution; (2) performing plasma modification to the polypropylene fiber braid; (3) adopting the electrospinning method to spray the polyvinylidene fluoride solution on the modified polypropylene fiber braid; and (4) shaping the composite fabric and drying. The hernia patch of the invention has stable structure and good mechanical properties and biocompatibility; by utilizing the good anti-adhesion property of polyvinylidene fluoride, the problem that the polypropylene hernia patch prepared from a single material is easy to be adhered with intestinal tissues can be overcome; and the preparation method is simple and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of hernia patch and its preparation, in particular to a polypropylene / polyvinylidene fluoride composite hernia patch and its preparation method. Background technique [0002] In daily life, the loss, damage or failure of human tissues and organs is very common, which poses a serious threat to people's health and life. For a long time, people have been exploring and researching materials and biotechnology, with the purpose of solving relevant problems in medicine, ensuring human health, and serving the prevention, diagnosis, treatment and rehabilitation of diseases. [0003] A hernia is when a part of a human tissue or organ leaves its original location and enters another through a gap, defect or weakness in the body. Hernia is a multiple disease, especially the elderly and children have a higher prevalence rate. Because hernia can cause multiple diseases, it constitutes a serious threat to people's health and life. ...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61L27/44
Inventor 杨庆黄丽媛郯志清沈新元张佩华王文祖刘潇沙楚涵
Owner DONGHUA UNIV
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