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Glossy ganoderma extract and pharmaceutical application thereof

The technology of Ganoderma lucidum extract and Ganoderma lucidum spores is applied in the field of Ganoderma lucidum extract and its pharmaceutical use, and can solve the problems of reducing the physiological activity of Ganoderma lucidum spore oil and preparations thereof, oxidative deterioration of Ganoderma lucidum spore oil by heating, unfavorable for the development and utilization of Ganoderma lucidum spore oil, etc. Achieve the effect of not easy to deteriorate, avoid oxidative damage, and low toxicity

Active Publication Date: 2012-09-05
吴新芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, the technology of breaking the wall of Ganoderma lucidum spores includes extrusion method, high-pressure homogenization method, ultrasonic wave, microwave heating method, etc. These wall breaking methods will cause difficulty in heat dissipation, resulting in thermal oxidation and deterioration of Ganoderma lucidum spore oil, thereby reducing the quality of Ganoderma lucidum spore oil and its preparations. Physiological activity, not conducive to the development and utilization of Ganoderma lucidum spore oil

Method used

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  • Glossy ganoderma extract and pharmaceutical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Preparation of Ganoderma lucidum spore wall-breaking powder:

[0062] Take 100g of Ganoderma lucidum spore powder, stir well in 1000ml of 10% ethanol-water mixed solvent, soak for 3 hours, make the spores absorb water and swell, soften the external tissue, add 8000 IU / g pectinase, 5000 IU / g cellulase , 1% Tween-80, enzymolysis temperature 35°C, pH 7.5, enzymolysis time 3 hours, centrifuged, filtered, and freeze-dried to obtain Ganoderma lucidum spore-broken wall powder.

[0063] Freeze-dried spore powder becomes agglomerated and brown, and is set aside.

Embodiment 2

[0065] Detection of Ganoderma lucidum spore broken wall powder:

[0066] in area lmm 2 , A counting disc with a depth of 1.10mm. A large square in the center is divided into 25 middle squares with double lines, and each middle square is divided into 16 small squares for counting purposes.

[0067] counting method

[0068] Use an electro-optical analytical balance (accuracy 0.01 mg) to weigh 1 mg of Ganoderma lucidum broken spore powder into a 5 mL test tube, add 1 mL of distilled water to the test tube, and shake for about 10 minutes to dissolve the broken Ganoderma lucidum spore powder in the water evenly to obtain Ganoderma lucidum spores of the suspension.

[0069] Use a micro-syringe (5 μL) to absorb 2 μL of the suspension, drop the suspension into the counting disk, cover it with a glass slide, and let it stand for 5 minutes. After the suspension is evenly distributed in the counting disk, count.

[0070] Under the light microscope, the spore wall is broken or not. Th...

Embodiment 3

[0077] The extraction method of the fat-soluble components of Ganoderma lucidum spores adopts ethanol-water as the extraction solvent:

[0078] Take 100g of Ganoderma lucidum broken spore powder, add 0.5% Tween-80 to 1000ml of ethanol-water mixed solvent with a volume ratio of 4:6, stir well for 2 hours, centrifuge, filter, and recover ethanol from the filtrate, then separate out Ganoderma lucidum from water The fat-soluble components of spores, Tween-80 is mostly dissolved in water, only a very small amount of Tween-80 dissolves in the fat-soluble components of Ganoderma lucidum spores, and the remaining Tween-80 in the fat-soluble components of Ganoderma lucidum spores is washed with water to obtain Ganoderma lucidum Spore-soluble component.

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Abstract

The invention relates to new preparation technology of glossy ganoderma extract and pharmaceutical application thereof, in particular to fat soluble extract of glossy ganoderma spore powder, a preparation method thereof, a preparation method of various formulations of the extract and application of the extract in the preparation of health-care products and medicaments which are used for senile dementia, Parkinson, Huntington chorea, cerebral palsy, stroke hemiplegia sequela or cerebral trauma sequela.

Description

technical field [0001] The present invention relates to Ganoderma lucidum extract and its product application. It specifically relates to a fat-soluble extract of Ganoderma lucidum spore powder, and also relates to the preparation method of the extract, the preparation method of various dosage forms of the extract, and its application in the preparation of senile dementia, Parkinson's disease, Huntington's disease, cerebral palsy, stroke, etc. The application of health products and medicines for hemiplegia sequelae, or brain trauma sequelae. Background technique [0002] With the advent of the aging era, the incidence of various central nervous degenerative diseases is gradually increasing. Western medicine believes that these diseases include: Alzheimer's disease and Parkinson's disease, learning and memory decline, and severe senile insomnia caused by brain aging Clinical manifestations are dementia, movement disorders, memory loss, and muscle tremors. Although Western m...

Claims

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Application Information

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IPC IPC(8): A61K36/074A61P25/28A61P25/16A61P25/14A61P9/10A61P25/02
Inventor 吴新芳
Owner 吴新芳