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Dipeptide iron chelate for feed additives and preparation method thereof

A technology for chelating iron and carbamoylglycine dipeptide, which is applied in dipeptide, animal feed, animal feed, etc., can solve the problem of poor stability of chelated iron, achieve low price, easy access to raw materials, and high absorption rate Effect

Active Publication Date: 2011-06-15
INST OF SUBTROPICAL AGRI CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the production process, because two amino acids are simply mixed before reacting with iron ions, or one amino acid is reacted with iron ions and then another amino acid is added for a mixed reaction, the two amino acids interact with iron in the form of ligands. ions, so the resulting chelated iron is not as stable as single amino acid chelated iron or glycine chelated iron, and this method is still bound by the traditional thinking of reacting amino acids with iron salts

Method used

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  • Dipeptide iron chelate for feed additives and preparation method thereof
  • Dipeptide iron chelate for feed additives and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment one, the preparation of dipeptide chelated iron

[0029] Step 1, the preparation of carbamoylglycine dipeptide:

[0030] Mix 100 grams of glycine and 60 grams of potassium cyanate, add 200 ml of water and 4 grams of potassium hydroxide, react at room temperature for 20 hours, adjust the pH to 4.5 with hydrochloric acid, crystallize at 0 ° C, filter and dry to obtain carbamoylglycine Dipeptide 115 grams. Step 2, the preparation of carbamoylglycine dipeptide chelated iron:

[0031]Take 100 grams of carbamoylglycine dipeptide, 50 grams of ferrous sulfate, add 200 milliliters of water, adjust pH=6 with 1.0 mol / L sodium hydroxide, heat on 65 °C water solution for 4 hours, filter the insoluble matter, and the filtrate Add 95% ethanol, precipitate out, and dry to obtain 65 grams of carbamoylglycine dipeptide chelated iron.

[0032] The valence state of iron element detected by potassium permanganate titration method or similar method is +2, the yield of carbamoyl...

Embodiment 2

[0033] Embodiment two, the preparation of dipeptide chelated iron

[0034] Step 1, the preparation of carbamoylglycine dipeptide

[0035] Mix 110 grams of glycine and 70 grams of potassium cyanate, add 210 milliliters of water, and add 5 grams of potassium hydroxide, react at room temperature for 21 hours, adjust to pH = 4.5 with hydrochloric acid, crystallize at 1 ° C, and filter to obtain carbamoglycine dipeptide 135 grams. Step 2, preparation of carbamoylglycine dipeptide chelated iron

[0036] Take 110 grams of carbamoylglycine dipeptide, 60 grams of ferrous sulfate, add 220 milliliters of water, use 1.5 mol / =sodium hydroxide, adjust pH=6.2, heat on 70 ° C water solution for 4.5 hours, filter the insoluble matter, add the filtrate 95% ethanol, precipitated, and dried to obtain 63.8 grams of carbamoylglycine dipeptide chelated iron.

[0037] Potassium permanganate titration method or similar method is used to detect the valence state of iron element as +2 valence, the yi...

Embodiment 3

[0038] Embodiment three, the preparation of dipeptide chelated iron

[0039] Step 1, the preparation of carbamoylglycine dipeptide

[0040] Mix 120 grams of glycine and 80 grams of potassium cyanate, add 215 milliliters of water and 5.5 grams of potassium hydroxide, react at room temperature for 22 hours, adjust to pH = 4.5 with hydrochloric acid, crystallize at 2°C, and filter to obtain carbamoylglycine dipeptide 145 grams. Step 2, preparation of carbamoylglycine dipeptide chelated iron

[0041] Take 120 grams of carbamoylglycinyl nitrogen dipeptide, 65 grams of ferrous sulfate, add 240 milliliters of water, use 2.0 mol / L sodium hydroxide to adjust the pH=6.8, heat it in water at 75 ° C for 5 hours, filter the insoluble matter, Add 95% ethanol to the filtrate, precipitate out, and dry to obtain 72 grams of carbamoylglycine dipeptide chelated iron.

[0042] The valence state of iron element detected by potassium permanganate titration method or similar method is +2, the yie...

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Abstract

The invention provides a method for preparing carbamyl glycine dipeptide iron chelate, which comprises the following steps: preparing carbamyl glycine dipeptide by utilizing glycine and potassium cyanate, preparing carbamyl glycine dipeptide iron chelate by utilizing the carbamyl glycine dipeptide and ferrous sulfate, and the like. The invention also provides carbamyl glycine dipeptide iron chelate prepared by the method, which is used for preparing feeds or additives for preventing baby pigs or pregnant sows from anemia. The product provided by the invention can effectively increase the hemoglobin concentration in the blood of sows and baby pigs during the parturition of the sows; and the method provided by the invention can replace the traditional method for complementing iron by injecting newborn baby pig muscle injections, thereby saving the labor force and being convenient to use.

Description

technical field [0001] The invention relates to a preparation method of dipeptide and dipeptide chelated iron, in particular to a preparation method of carbamoylglycine dipeptide chelated iron. Background technique [0002] Iron is an essential mineral for the animal body. It is an important component of hemoglobin (the substance that transports oxygen in the blood), and is involved in the process of oxygen transport and energy production. Iron deficiency can lead to stunted growth, low disease resistance, reduced feed conversion, poor reproductive performance, anemia, diarrhea and sometimes piglet death. In addition, it has been reported that iron deficiency can aggravate bleeding symptoms caused by some infectious pathogens, such as Trichuris suis. [0003] Pregnant sows transfer iron to the fetus partly through uterine transferrin (a yellow guide protein secreted by the uterus), and the reduction of uterine iron transfer in late pregnancy is considered to be a cause of a...

Claims

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Application Information

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IPC IPC(8): C07K5/06A23K1/16A23K20/147A23K20/20A23K50/30A23K50/60
Inventor 吴信印遇龙舒绪刚
Owner INST OF SUBTROPICAL AGRI CHINESE ACAD OF SCI
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