Method for detecting nitromethane in cosmetics by using gas chromatograph-mass spectrography
A technology of gas chromatography and mass spectrometry, which is applied in the field of gas chromatography-mass spectrometry detection of nitromethane in cosmetics
Inactive Publication Date: 2011-06-15
CHINESE ACAD OF INSPECTION & QUARANTINE
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Problems solved by technology
[0004] At present, the detection of nitromethane in cosmetics is still in a blank stage
Method used
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Embodiment 1
[0016] (1) Sample pretreatment
[0017] Dichloromethane (chromatographically pure), nitromethane standard substance (purity ≥ 97%), methanol (chromatographically pure)
[0018] Preparation of nitromethane standard stock solution: Accurately weigh 0.100g (accurate to 0.001g) nitromethane, place it in a 100mL volumetric flask, dilute to 100mL with dichloromethane, and shake well.
[0019] Nitromethane standard solution: Dilute the nitrethane standard stock solution with dichloromethane to 0.02μg / mL, 0.1μg / mL, 0.2μg / mL, 1.0μg / mL, 2.0μg / mL solutions respectively.
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Abstract
The invention discloses a method for detecting nitromethane in cosmetics by using the gas chromatograph-mass spectrography, which comprises the following steps of: adding methanol in a sample to be detected, ultrasonically extracting, centrifuging an extract, taking the supernate, drying the supernate, filtering the dried supernate with an organic filter membrane, obtaining the filtrate, and carrying out the gas chromatogram-mass spectrum detection on the filtrate; a chromatographic column of the gas chromatogram is of bonding / cross-linked polyglycolic stationary-phase, wherein the temperature of the chromatographic column is increased in a programmed way, is maintained at 35 DEG C for 3 minutes, then increased to 100 DEG C by the increase rate of 10 DEG C / min and maintained at 100 DEG C for 2 minutes, and increased to 200 DEG C by the increase rate of 30 DEG C / min, the samples are fed in a split way, and the split ratio is 5 to 1. The method for detecting nitromethane in cosmetics by using the gas chromatograph-mass spectrography is fast, and has low detection limit and high recovery rate.
Description
technical field [0001] The invention relates to a method for detecting nitromethane in cosmetics by gas chromatography-mass spectrometry. Background technique [0002] Nitromethane is commonly used in pharmaceuticals, dyes and other additives, and is often used in the synthesis of a cosmetic preservative. It can cause damage to the central nervous system, damage the liver and kidneys, and is highly toxic. [0003] Bropol is one of the preservatives approved by the U.S. Food and Drug Administration for use in cosmetics. It is a broad-spectrum antibacterial agent. It has no irritation and allergic reactions to human skin when used in cosmetics at a concentration of 0.01-0.1%. Due to improper production and storage of Bropol and negligence in the production of cosmetics, cosmetics may contain nitromethane. [0004] At present, the detection of nitromethane in cosmetics is still in a blank stage. Contents of the invention [0005] The object of the present invention is to pr...
Claims
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IPC IPC(8): G01N30/02G01N30/08
Inventor 马强刘茜王超白桦苏宁王烨席海为
Owner CHINESE ACAD OF INSPECTION & QUARANTINE