Integrative novel preparation theory of medicines and production method thereof

A production method and an integrated technology, applied in drug delivery, pharmaceutical formulations, plant raw materials, etc., can solve problems such as uncertainty in the quality of new substances, and achieve the effects of reducing product quality, improving product quality, and strong slow and controlled release

Inactive Publication Date: 2011-06-22
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the amount of the new substance is uncertain, the current view is that it only plays a synergistic or adjuvant role

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Prepare the following raw materials by the aforementioned method:

[0054] Concentrated extract, nanoliposome, microemulsion, nanoemulsion, nanosuspension.

[0055] Its manufacturing process is as follows:

[0056] In the GMP10000 clean room, the concentrated extract, nanoliposome, microemulsion, nanoemulsion, and nanosuspension are mixed according to the ratio of 2:2:2:2:2, and the latest version of the "Chinese Pharmacopoeia" preparation part is used. Soft capsule standard, without adding auxiliary materials and preservatives, is filled by a fully automatic soft capsule filling machine to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report.

Embodiment 2

[0058] Prepare the following raw materials by the aforementioned method:

[0059] Active substance group dry powder, nanoparticles, solid lipid nanoparticles, microcapsules, lipid microspheres, nanocapsules, microcapsules.

[0060] Its manufacturing process is as follows:

[0061] In the GMP10000 clean room, the effective substance group dry powder, nanoparticles, solid lipid nanoparticles, microcapsules, lipid microspheres, nanocapsules, and microcapsules are processed in a ratio of 3:1:1:1:1:1:2. After mixing, adopt the latest version of the "Chinese Pharmacopoeia" preparation part of the hard capsule standard, without adding auxiliary materials and preservatives, and use a full-automatic capsule filling machine to fill the hard capsule to make a hard capsule. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a steriliza...

Embodiment 3

[0063] Prepare the following raw materials by the aforementioned method:

[0064] Nanoemulsions, lipid microspheres, nanomembranes, nanosuspensions, nanoliposomes, polymer micelles. Its manufacturing process is as follows:

[0065]After mixing nanoemulsions, lipid microspheres, nanomembranes, nanosuspensions, nanoliposomes, and polymer micelles at a ratio of 2:1:2:2:1:2 in a GMP10000 clean room, use In the 2005 edition of the Chinese Pharmacopoeia, the second part of the preparation film standard, the film-forming material is made of polyvinyl alcohol to make a nano-Chinese medicine film, and then the internal and external packaging such as boxing, sealing, labeling, coding, and boxing. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 1-40 square centimeters, the drug content is 1.2-5 grams, and each film is applied for 12-72 hours. The application site: neck, chest, back, abdomen, legs, sole...

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Abstract

The invention relates to an integrative novel preparation theory of medicines and a production method thereof. The theory, the preparation and the production process comprise the following steps of: carrying out the reasonable integration according to the factors of the integral conception of traditional Chinese medicine science, the pharmacological efficacy of western medicine science, the sizes of nanometer particles, the preparation process and the like, finally forming different medical targeting systems. And the novel treatment solution and effect of combination of the traditional Chinese medicine science and the western medicine science with combination of a direct method and an indirect method and mutual supplementary of yin and yang are generated. The invention pays attention to the advantages of nanometer medicines, such as multiple synergism and the like. The preparation and the production integrates the techniques of alcohol-water, ultrasonic wave, microwave extraction, drying while spraying, high-pressure homogenization, nano grinding, polymerization package and the like. After the novel preparation disclosed by the invention is produced in an industrial scale, the production cost can be greatly reduced, the quality of the product can be improved, the toxic and side effects of whole body can be reduced, and the target performance and the controlled release performance of the medicines are stronger.

Description

technical field [0001] The present invention relates to a new drug-integrated preparation theory and preparation technology, and also relates to a drug-integrated new preparation theory and preparation technology and a production method thereof. Background technique [0002] The relevant laws and regulations on drug management in my country stipulate that changing dosage forms is managed as a new drug research. The level of drug development can reflect the economic and technical strength of a country's pharmaceutical industry. The development of heavyweight new drugs is the dream goal of many pharmaceutical companies. The backwardness of the level of preparations not only affects the efficacy of drugs, but also leads to low added value of drugs, which directly affects market competition and industrial economic benefits. This is why the number of products in my country's pharmaceutical industry ranks among the top in the world and the output value is only equivalent to one o...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K36/00
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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