Composition of oral pharmacologic active agent

A composition and drug technology, applied in the directions of drug combinations, organic active ingredients, pharmaceutical formulations, etc., can solve the problems of complex preparation process and difficult industrialized production, and achieve improved bioavailability, improved permeability, and good product stability. Effect

Inactive Publication Date: 2011-06-22
刘青松
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The preparation process of the preparation is complex, diffi

Method used

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  • Composition of oral pharmacologic active agent
  • Composition of oral pharmacologic active agent

Examples

Experimental program
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Example Embodiment

[0039] Example 1: Preparation of oral liquid

[0040] Dissolve calcitonin 0.2mg and edetate disodium 1.0mg in 0.5ml physiological saline, mix Tween80 1.0mg, Span801.2mg, soybean oil 1.4mg, ethanol 1.1mg and other components uniformly, add appropriate amount of Bath The sweet and benzalkonium bromide are mixed uniformly to obtain 5ml of a clear mixed liquid, which is then filled in a vial, capped, sealed, and sterilized by irradiation.

Example Embodiment

[0041] Example 2: Preparation of soft capsules

[0042] Dissolve 20mg of calcitonin and 10mg of salicylic acid in 45ml of normal saline, mix and dissolve Tween80 91mg, soybean phospholipid 91mg, medium chain oil 182mg, propylene glycol 91mg and other components uniformly, and add appropriate amount of vitamin E and benzalkonium chloride , After mixing evenly, press into 1000 soft capsules.

Example Embodiment

[0043] Example 3: Preparation of soft capsules

[0044] Dissolve 19mg of low molecular weight heparin and 1.6mg of sodium deoxycholate in 48ml of normal saline. Mix and dissolve Tween80 76mg, soy phospholipid 76mg, caprylic / capric glyceride 228mg, propylene glycol 76mg and other components, and add appropriate amount of vitamins. E. Benzalkonium chloride, mixed evenly and compressed into 1000 soft capsules.

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Abstract

The invention relates to a composition of an oral pharmacologic active agent, a method for improving oral bioavailability and a method for treating and/or preventing diseases of mammals and particularly humans by the oral administration of the medicinal composition. The composition comprises water-soluble macromolecular medicaments, a dispersing agent, an auxiliary stabilizing agent, a hydrophobic medium, water and other optional pharmaceutic adjuvants. The preparation method of the composition is simple, and the oral bioavailability of the medicaments can be greatly improved.

Description

technical field [0001] The present invention relates to compositions for oral administration of pharmacologically active agents, methods for increasing the bioavailability of oral administration, and methods for treating and / or preventing diseases in mammals, especially humans, by orally administering the pharmaceutical composition of the present invention. Background technique [0002] Oral administration is the route of administration with the best patient compliance, but with the development of biotechnology, protein and polypeptide drugs are more and more widely used in clinical practice, such as calcitonin, insulin, thymosin, etc. Peptide drugs are mainly administered by injection at present, and the patient compliance is poor. Oral dosage forms are easily accepted by patients, but the biggest problem with the oral administration of such drugs is that the body's physical, chemical and biological barriers affect their delivery. Physical barriers such as mucous membranes...

Claims

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Application Information

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IPC IPC(8): A61K38/23A61K31/727A61K47/44A61P19/08A61P3/14
Inventor 刘艳李馨儒范雅婷周艳霞
Owner 刘青松
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