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Composition of oral pharmacologic active agent

A composition and drug technology, applied in the directions of drug combinations, organic active ingredients, pharmaceutical formulations, etc., can solve the problems of complex preparation process and difficult industrialized production, and achieve improved bioavailability, improved permeability, and good product stability. Effect

Inactive Publication Date: 2011-06-22
刘青松
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of the preparation is complex, difficult to industrialized production and uses an organic solvent

Method used

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  • Composition of oral pharmacologic active agent
  • Composition of oral pharmacologic active agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: the preparation of oral liquid

[0040]Dissolve calcitonin 0.2mg and edetate disodium 1.0mg in 0.5ml normal saline, mix Tween80 1.0mg, Span80 1.2mg, soybean oil 1.4mg, ethanol 1.1mg and other components evenly, add appropriate amount of Bath Sweet and benzalkonium bromide, mix evenly, obtain 5ml clear mixed solution, then fill it in the vial, add a cap, seal, and radiate sterilization to get final product.

Embodiment 2

[0041] Embodiment 2: the preparation of soft capsule

[0042] Dissolve calcitonin 20mg and salicylic acid 10mg in 45ml of normal saline, mix and dissolve Tween80 91mg, soybean lecithin 91mg, medium chain oil 182mg, propylene glycol 91mg and other components evenly, and add appropriate amount of vitamin E and benzalkonium chloride , mixed evenly and compressed into 1000 soft capsules.

Embodiment 3

[0043] Embodiment 3: the preparation of soft capsule

[0044] Dissolve 19mg of low-molecular-weight heparin and 1.6mg of sodium deoxycholate in 48ml of normal saline, mix and dissolve 76mg of Tween80, 76mg of soybean lecithin, 228mg of caprylic / capric glyceride, 76mg of propylene glycol and other components, and add an appropriate amount of vitamin E, benzalkonium chloride, after mixing uniformly, be compressed into 1000 soft capsules.

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Abstract

The invention relates to a composition of an oral pharmacologic active agent, a method for improving oral bioavailability and a method for treating and / or preventing diseases of mammals and particularly humans by the oral administration of the medicinal composition. The composition comprises water-soluble macromolecular medicaments, a dispersing agent, an auxiliary stabilizing agent, a hydrophobic medium, water and other optional pharmaceutic adjuvants. The preparation method of the composition is simple, and the oral bioavailability of the medicaments can be greatly improved.

Description

technical field [0001] The present invention relates to compositions for oral administration of pharmacologically active agents, methods for increasing the bioavailability of oral administration, and methods for treating and / or preventing diseases in mammals, especially humans, by orally administering the pharmaceutical composition of the present invention. Background technique [0002] Oral administration is the route of administration with the best patient compliance, but with the development of biotechnology, protein and polypeptide drugs are more and more widely used in clinical practice, such as calcitonin, insulin, thymosin, etc. Peptide drugs are mainly administered by injection at present, and the patient compliance is poor. Oral dosage forms are easily accepted by patients, but the biggest problem with the oral administration of such drugs is that the body's physical, chemical and biological barriers affect their delivery. Physical barriers such as mucous membranes...

Claims

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Application Information

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IPC IPC(8): A61K38/23A61K31/727A61K47/44A61P19/08A61P3/14
Inventor 刘艳李馨儒范雅婷周艳霞
Owner 刘青松
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