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Clathrate of paeonol and preparation method and quality detection method thereof

A paeonol and clathrate technology, which is applied in the field of clathrates of active ingredients in traditional Chinese medicine, can solve the problems of unfavorable large-scale industrial production, long time spent, and low yield.

Active Publication Date: 2011-07-06
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing paeonol β-cyclodextrin inclusion technology is heating and stirring method, ultrasonic method, etc., which is not conducive to large-scale industrial production, and the yield is not high, and it takes a long time

Method used

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  • Clathrate of paeonol and preparation method and quality detection method thereof
  • Clathrate of paeonol and preparation method and quality detection method thereof
  • Clathrate of paeonol and preparation method and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0141] 1. Preparation of paeonol inclusion compound:

[0142] Take β-cyclodextrin of 6 times the amount of paeonol, add 2 times the amount of water and stir well, heat to 55°C; take paeonol and add 4 times the amount of 85% ethanol, heat to dissolve and pour into β-cyclodextrin Grind in the fine solution for 15 minutes with a colloid mill, discharge the material, place it at room temperature for 14 hours, filter it with suction, and dry it at 40°C to obtain paeonol inclusion compound.

[0143] 2. Detection of paeonol inclusion complex

[0144] (1) Chromatographic conditions: gas chromatograph; capillary chromatographic column with 5% diphenyl-95% dimethylsilane copolymer as stationary phase; inlet temperature: 230°C; detector temperature (FID): 240°C ;Split ratio: 25:1; Temperature program: initial temperature 80°C, keep for 2min, increase to 160°C at 20°C per minute, keep for 6min, measure; carrier gas: nitrogen, flow rate: 1.0ml / min; injection: 2μl ; The number of theoreti...

Embodiment 2

[0150] 1. Preparation of paeonol inclusion compound:

[0151] Take β-cyclodextrin of 10 times the amount of paeonol, add 2.7 times the amount of purified water and stir well, heat to 60°C; take paeonol and add 5 times the amount of 95% ethanol, heat to dissolve and pour into β-cyclodextrin Grind in dextrin solution for 20 minutes with a colloid mill, discharge, stand at room temperature for 24 hours, filter with suction, and dry at 50°C to obtain paeonol inclusion compound. Detection of paeonol inclusion complex

[0152] (1) Chromatographic conditions: gas chromatograph; capillary chromatographic column with 5% diphenyl-95% dimethylsilane copolymer as stationary phase; inlet temperature: 220°C; detector temperature (FID): 230°C ; Split ratio: 20:1; Temperature program: initial temperature 80°C, keep 2min, increase to 160°C at 20°C per minute, keep 6min, measure; carrier gas: nitrogen, flow rate: 1.0ml / min; sample injection: 5μl ; The number of theoretical plates is calculat...

Embodiment 3

[0158] 1. Preparation of paeonol inclusion compound:

[0159] Take β-cyclodextrin with 14 times the amount of paeonol, add 4 times the amount of water and stir well, heat to 70°C; take paeonol and add 7 times the amount of 90% ethanol, heat to dissolve and pour into β-cyclodextrin Grind in the fine solution for 30 minutes with a colloid mill, discharge the material, place it at room temperature for 24 hours, filter it with suction, and dry it at 60°C to obtain paeonol inclusion compound.

[0160] 2. Detection of paeonol inclusion complex

[0161] (1) Chromatographic conditions: gas chromatograph; capillary chromatographic column with 5% diphenyl-95% dimethylsilane copolymer as stationary phase; inlet temperature: 240°C; detector temperature (FID): 250°C ;Split ratio: 25:1; Temperature program: initial temperature 80°C, keep for 2min, increase to 160°C at 20°C per minute, keep for 6min, measure; carrier gas: nitrogen, flow rate: 1.0ml / min; injection: 10μl ; The number of theo...

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Abstract

The invention relates to a clathrate of paeonol and the preparation method and the quality detection method thereof. The preparation method of the clathrate of paeonol comprises the following steps: adding beta-cyclodextrin into water, stirring, and heating; adding paeonol into ethanol, heating to dissolve, pouring into the beta-cyclodextrin solution, milling with a colloidal mill, discharging, standing at room temperature, performing suction filtering, and drying.

Description

Technical field: [0001] The invention relates to an inclusion compound of an active ingredient of a traditional Chinese medicine, a preparation method and a quality detection method thereof, in particular to an inclusion compound of paeonol, the main component of the Chinese medicine Cortex Moutan, and a preparation method and a quality detection method thereof. technical background: [0002] Paeonol is the main active ingredient of the traditional Chinese medicine Moutan Cortex, which has a wide range of pharmacological effects. Because paeonol has strong volatility and is unstable when exposed to light, heat, and humidity, β-cyclodextrin (cyclodextrin, β- CD) clathrate paeonol to reduce its volatility, increase its stability, and make paeonol crystal solid powder, which is convenient for making various dosage forms and improving curative effect. [0003] "Strait Pharmacy" No. 5, 2005 recorded Zhang Jianjun and Tu Yaosheng's paper "Research on Paeonol Inclusion Process by O...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K47/48G01N30/02G01N30/06A61K47/69
Inventor 萧伟王振中王正宽窦霞邓彬章晨峰陈凤龙
Owner JIANGSU KANION PHARMA CO LTD
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