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Modified keratin material as well as preparation method and application thereof

A keratin material and keratin technology, which are applied in the field of biomedical materials, can solve the problems of large structural damage, irreversible cross-linking reaction, lack of selectivity, etc., and achieve the advantages of increased cross-linking degree, enhanced chemical stability and simple preparation method. Effect

Inactive Publication Date: 2011-07-13
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a keratin molecule that is difficult to degrade and whose degree of degradation can be adjusted within a certain range according to the existing problems such as large structural damage, irreversible cross-linking reaction, lack of selectivity, and easy degradation in the existing keratin molecular modification effect. modified keratin material

Method used

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  • Modified keratin material as well as preparation method and application thereof
  • Modified keratin material as well as preparation method and application thereof
  • Modified keratin material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Take human hair, wash it with surfactant, rinse it with deionized water repeatedly, and dry it in an oven at 80°C.

[0045] (2) Loaded into a Soxhlet extractor, degreasing with a 1:1 ethanol-ether mixed solvent for 6 hours, rinsed and dried with deionized water repeatedly for use.

[0046] (3) Soak the washed and degreased human hair in a mixed solution of 30% hydrogen peroxide and concentrated ammonia water (volume ratio 3:1), and keep it at room temperature for 1 hour, so that the human hair can be completely depigmented. Then washed and dried.

[0047] (4) Prepare a solution of thioglycolic acid 0.2 mol / L and guanidine hydrochloride 6 mol / L. After degreasing, the human hair samples were soaked in the extraction solution at a mass ratio of 1:100, soaked at room temperature for 2 hours, and reacted at 50 °C for 12 hours.

[0048] (5) The extract is filtered and centrifuged, and the filtrate is dialyzed against water for about 36 hours through a dialysis membrane ...

Embodiment 2

[0055] (1) Take human hair, soak it in washing powder, rinse it with deionized water repeatedly, and dry it in an oven at 80°C.

[0056] (2) Put it into a distillation flask, add chloroform that accounts for 10 times the mass of human hair, reflux extraction, degreasing for 4 hours, separate out the chloroform, add 10 times the mass of acetone, stir at room temperature for 1 hour, filter out the acetone, and use deionized water for the hair sample. Rinse and dry repeatedly.

[0057] (3) Soak the degreased and washed human hair in 30% hydrogen peroxide and keep it at room temperature for 3 hours to completely remove the pigment from the human hair. Then washed and dried.

[0058] (4) Prepare a solution of 0.5 mol / L mercaptoethanol and 8 mol / L guanidine hydrochloride.

[0059] (5) After degreasing, the human hair samples were soaked in the extraction solution at a mass ratio of 1:100, soaked at room temperature for 2 hours, and then reacted at 60 °C for 12 hours.

[0060] (6)...

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Abstract

The invention discloses a modified keratin material as well as a preparation method and application thereof. The modified keratin material provided by the invention has a structural formula shown in a formula (I) in the specification. The invention further provides the preparation method of the modified keratin material. The modified keratin material provided by the invention is degradable or degraded slowly after being implanted inside a human body, and the degradation degree of the modified keratin material can be regulated by controlling preparation process parameters. The prepared modified keratin material can be applied to hemostasis materials, hydrogel, wound dressing, and soft tissue fillers and the like, and can also be used as a support material for building a tissue engineered tissue.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a modified keratin material and its preparation method and application. Background technique [0002] At present, the research on keratin at home and abroad mainly focuses on the extraction technology and performance research, and seldom involves the modification of keratin materials. [0003] In general, the disulfide bonds in keratin molecules make the peptide chains and peptide chains cross-linked to form a three-dimensional network structure, which makes natural keratin difficult to dissolve and brings great benefits to the extraction, processing and application of keratin in hair. come difficult. To obtain keratin with higher molecular weight and better solubility, it can only be achieved by selectively opening disulfide bonds and destroying hydrogen bonds. At present, the methods for extracting keratin generally include mechanical methods, chemical methods an...

Claims

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Application Information

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IPC IPC(8): C07K1/113
Inventor 谢德明
Owner JINAN UNIVERSITY
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