Oral medicine preparation and preparation method thereof
A pharmaceutical preparation and drug technology, applied in the field of oral instant film preparation and its preparation, can solve the problems of inaccurate dosage, inconvenient swallowing, and difficult to carry, and achieve the effects of stable drug quality, good taste, and high production efficiency
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Embodiment 1
[0029] prescription:
[0030]
[0031]
[0032] In this embodiment, the main ingredient is cefaclor, the polymer film-forming agent is polyvinylpyrrolidone and hydroxyethyl cellulose, polyethylene glycol 400 is a plasticizer, anion exchange resin, menthol and sucralose are masking agents. Flavor agent, FD&C edible red coloring No. 40 is used to increase the appearance aesthetic feeling of film.
[0033] The preparation process of the present embodiment is carried out through the following steps:
[0034] 1. Dissolve 15g of cefaclor as the main drug in the above prescription in 1800g of water at 40°C, add anion exchange resin, and stir for 24 hours;
[0035] 2. Remove moisture by suction filtration under reduced pressure to make cefaclor / anion exchange resin compound;
[0036] 3. Add 10.4g of polyvinylpyrrolidone and 11.3g of hydroxyethyl cellulose to 180g of water at 40°C and stir for 2 hours as the above-mentioned auxiliary materials;
[0037] 4. Add 20g of 40°C wate...
Embodiment 2
[0045] prescription:
[0046]
[0047]
[0048] The present embodiment main medicine is aripride, and macromolecular polymer film-forming agent is polyvinylpyrrolidone and hydroxypropyl cellulose, polyethylene glycol 400 is plasticizer, cation exchange resin (U.S. Rohm and Haas Company) Amberlite IRA400) and xylitol are taste-masking agents, and FD&C edible blue pigment No. 1 and red pigment No. 40 are used to increase the aesthetic appearance of the film.
[0049] The preparation process of the present embodiment is carried out through the following steps:
[0050] 1. Dissolve 5g of aripride as the main drug in the above prescription in 100g of absolute ethanol, add cation exchange resin, and stir for 4 hours;
[0051] 2. Rotating vacuum distillation to remove absolute ethanol to make aripride / cation exchange resin compound;
[0052] 3. Add 12.7g of polyvinylpyrrolidone and 17.9g of low molecular weight hydroxypropyl cellulose to 180g of water at 40°C and stir for 2 h...
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