Check patentability & draft patents in minutes with Patsnap Eureka AI!

Oral medicine preparation and preparation method thereof

A pharmaceutical preparation and drug technology, applied in the field of oral instant film preparation and its preparation, can solve the problems of inaccurate dosage, inconvenient swallowing, and difficult to carry, and achieve the effects of stable drug quality, good taste, and high production efficiency

Inactive Publication Date: 2011-08-03
于晓勇
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The advantage of liquid oral medicine is that it is easy and convenient to take, and it does not need to be taken with water; the disadvantage is that it is large in size, not easy to carry, needs a container to measure when taking it, and the dosage is not accurate, etc.
The advantage of solid oral medicine is that the package is small, easy to carry, and the dosage is accurate; its disadvantage is that it needs to be taken with water, which causes inconvenience to patients who have difficulty swallowing, such as the elderly and children.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oral medicine preparation and preparation method thereof
  • Oral medicine preparation and preparation method thereof
  • Oral medicine preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] prescription:

[0030]

[0031]

[0032] In this embodiment, the main ingredient is cefaclor, the polymer film-forming agent is polyvinylpyrrolidone and hydroxyethyl cellulose, polyethylene glycol 400 is a plasticizer, anion exchange resin, menthol and sucralose are masking agents. Flavor agent, FD&C edible red coloring No. 40 is used to increase the appearance aesthetic feeling of film.

[0033] The preparation process of the present embodiment is carried out through the following steps:

[0034] 1. Dissolve 15g of cefaclor as the main drug in the above prescription in 1800g of water at 40°C, add anion exchange resin, and stir for 24 hours;

[0035] 2. Remove moisture by suction filtration under reduced pressure to make cefaclor / anion exchange resin compound;

[0036] 3. Add 10.4g of polyvinylpyrrolidone and 11.3g of hydroxyethyl cellulose to 180g of water at 40°C and stir for 2 hours as the above-mentioned auxiliary materials;

[0037] 4. Add 20g of 40°C wate...

Embodiment 2

[0045] prescription:

[0046]

[0047]

[0048] The present embodiment main medicine is aripride, and macromolecular polymer film-forming agent is polyvinylpyrrolidone and hydroxypropyl cellulose, polyethylene glycol 400 is plasticizer, cation exchange resin (U.S. Rohm and Haas Company) Amberlite IRA400) and xylitol are taste-masking agents, and FD&C edible blue pigment No. 1 and red pigment No. 40 are used to increase the aesthetic appearance of the film.

[0049] The preparation process of the present embodiment is carried out through the following steps:

[0050] 1. Dissolve 5g of aripride as the main drug in the above prescription in 100g of absolute ethanol, add cation exchange resin, and stir for 4 hours;

[0051] 2. Rotating vacuum distillation to remove absolute ethanol to make aripride / cation exchange resin compound;

[0052] 3. Add 12.7g of polyvinylpyrrolidone and 17.9g of low molecular weight hydroxypropyl cellulose to 180g of water at 40°C and stir for 2 h...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an oral medicine preparation and a preparation method thereof. The oral medicine preparation is a membrane preparation prepared from pharmaceutically effective amount of active medicines and auxiliary materials which are uniformly dispersed in water on a coating machine through a solution coating method, wherein the auxiliary materials comprise at least one water-soluble high polymer, an ion exchange resin and other adjuvant. Compared with the prior art, the prepared orally instant membrane preparation can be quickly dissolved when the preparation is mixed with saliva in an oral cavity. The medicine can be quickly absorbed in the systemic circulation through oral mucosa and gastrointestinal tracts after changing into liquid, and the preparation has good mouthfeel, no sand feeling and bitter. The solution coating method adopted in the invention is the first production process in the pharmaceutical industry at home; produced medicines has stable quality; the production efficiency is high; low cost is needed; and the market prospect is extremely broad.

Description

technical field [0001] The invention relates to a novel oral pharmaceutical preparation and a preparation method thereof, in particular to an oral instant film preparation and a preparation method thereof. Background technique [0002] In pharmacy, pharmaceutical preparations are divided into oral pharmaceutical preparations and non-oral pharmaceutical preparations according to the route of administration. Oral pharmaceutical preparations are administered orally and absorbed through the gastrointestinal tract. Such as: oral solutions, emulsions, suspensions, granules, capsules, tablets, etc. Among them, liquid dosage forms include oral solutions, emulsions, suspensions, etc., while granules, capsules and tablets belong to solid dosage forms. [0003] The advantage of liquid oral medicine is that it is easy and convenient to take, and it does not need to be taken with water; the disadvantage is that it is large in size, not easy to carry, needs a container to measure when t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/70A61K47/30
Inventor 于晓勇
Owner 于晓勇
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More