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Oil-in-water type sea buckthorn oil nano-emulsion oral liquid and preparation method thereof

An emulsion oral liquid, oil-in-water type technology, applied in the field of medicine, can solve the problems of low bioavailability of seabuckthorn oil oil, poor solubility of seabuckthorn oil, unstable physical and chemical properties, etc., to improve bioavailability and thermodynamic stability High, solubility-enhancing effect

Inactive Publication Date: 2011-08-31
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But seabuckthorn oil has poor solubility, is insoluble in alcohols such as water, ethanol, 1,2-propylene glycol, and its physical and chemical properties are unstable and volatile; and the bioavailability of seabuckthorn oil is low, absorbed quickly, and eliminated quickly, thereby Reduced curative effect

Method used

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  • Oil-in-water type sea buckthorn oil nano-emulsion oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045]Mix 30.0 g of RH400 and 7.0 g of seabuckthorn oil and stir well, then slowly add 63.0 g of distilled water dropwise to the mixture, and stir while adding. During the process of adding water and stirring, the mixture system will change from thin to thick, and finally by A series of changes from thickening to thinning until the oil-in-water microemulsion is formed.

Embodiment 2

[0047] Tween-80 38.0g, ethyl acetate 2.00g, seabuckthorn oil 3.0g, distilled water 57.0g.

Embodiment 3

[0049] RH402 3.0g, triacetin 7.0g, seabuckthorn oil 0.10g, distilled water 69.9g.

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Abstract

The invention discloses an oil-in-water type sea buckthorn oil nano-emulsion oral liquid. The drop diameter of the oral liquid is 10-100nm. The oral liquid comprises the following components used as raw materials: 23.0-40.0% of surfactant, 0-7.0% of oil, 0.1-7.0% of sea buckthorn oil and the balance of distilled water, wherein the sum of the mass percents of the components is 100%. The oral liquid disclosed by the invention enhances the solubility of the sea buckthorn oil, improves the drug stability, improves the bioavailability of the sea buckthorn oil, delays the drug metabolism time of the sea buckthorn oil in bodies, reduces the dose of assistants, lowers the production cost, and has wide market prospects in the medicine field.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a medicine that can reduce blood fat, soften blood vessels, promote lipid transfer and removal, prevent and treat atherosclerosis, strengthen the spleen and nourish the stomach, soothe the liver and regulate qi, relieve cough and asthma, benefit the lungs and reduce phlegm, antibacterial and anti-inflammatory , a new dosage form of seabuckthorn oil drug that can resist fatty liver and liver cirrhosis, and improve the body's immunity. In particular, it relates to a clear and transparent oil-in-water seabuckthorn oil nanoemulsion oral liquid and a preparation method thereof. Background technique [0002] Sea buckthorn oil is a pure natural vegetable oil extracted from the seeds of sea buckthorn. It is rich in nutrients such as vitamin C and vitamin E, especially contains a large amount of fatty acids, of which 11.6% are saturated fatty acids, and the rest are unsaturated fatty acids, of which...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/107A61K47/22A61K47/34A61K47/44A61P1/16A61P3/06A61P9/12A61P11/06A61P11/10A61P11/14A61P37/04A61K47/14A61K47/26
Inventor 欧阳五庆吴敬超李雅
Owner NORTHWEST A & F UNIV
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