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A spray for treating diseases caused by human papilloma viruses and a preparation method

A technology of human papilloma virus and spray, which is applied in the field of medicine to achieve the effect of enhancing the phagocytic ability and activating the phagocytic function

Active Publication Date: 2015-05-20
孙介光 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the external dosage form and preparation method of inhibiting human papillomavirus and treating tumors caused by human papillomavirus infection and using purified human rabies vaccine to treat sexually transmitted diseases have not yet been reported.

Method used

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  • A spray for treating diseases caused by human papilloma viruses and a preparation method
  • A spray for treating diseases caused by human papilloma viruses and a preparation method
  • A spray for treating diseases caused by human papilloma viruses and a preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Spray composition of the present invention:

[0031] According to the volume ratio, the purified human rabies vaccine whose composition is 1ml is diluted to 10ml by adding a chitosan-acetic acid solution with a mass volume concentration of 0.01g / ml.

[0032] The specific configuration method is as follows:

[0033] 1. Prepare chitosan-acetic acid solution (pH=3.2)

[0034] (1) Prepare 0.3% acetic acid solution: add 3 ml of glacial acetic acid (analytical pure) to a 1000 ml volumetric flask, add pure water to the mark, and use double distilled water as the pure water here to obtain a 0.3% acetic acid solution by volume ;

[0035] (2) Prepare a chitosan-acetic acid solution with a mass volume concentration of 0.01g / ml: weigh 10g of chitosan and add it to the above-mentioned acetic acid solution to completely dissolve to 1000ml. Volume concentration is the chitosan-acetic acid solution of 0.01g / ml;

[0036] (3) According to the pH value of the chitosan-acetic acid solu...

Embodiment 2

[0041] The difference from Example 1 is:

[0042] 1. Prepare chitosan-acetic acid solution (pH=4.9):

[0043]The glacial acetic acid 4ml that the acetic acid solution of preparation 0.4% adopts is (chemically pure); It is the sodium hydroxide solution of 0.1mol / L or the acetic acid solution that the volume molar concentration is 0.1mol / L to adjust the pH value to 4.9.

[0044] Prepare the chitosan-acetic acid solution that the mass volume concentration is 0.02g / ml: take by weighing chitosan 20g and add to the above-mentioned acetic acid solution and dissolve completely to 1000ml, the solution does not allow insoluble particles or insoluble matter to be made into a mass volume concentration of 0.02g / ml chitosan-acetic acid solution.

[0045] 2. Vaccine Solution Preparation

[0046] Take 1ml of freeze-dried human rabies purified vaccine with an activity unit of 15IU (two in this embodiment, each 0.5ml, 7.5IU) and add it to a 10ml measuring bottle. PV strain. Add chitosan-ace...

Embodiment 3

[0048] The difference from Example 1 is:

[0049] 1. Prepare chitosan-acetic acid solution (pH=5.0):

[0050] The 10ml of glacial acetic acid used to prepare the 1.0% acetic acid solution is chemically pure; adjust the pH to 5.0 with a sodium hydroxide solution with a molar concentration of 0.1mol / L or an acetic acid solution with a molar concentration of 0.1mol / L.

[0051] Preparation mass volume concentration is the chitosan-acetic acid solution of 0.03g / ml: Take chitosan 30g and add to the above-mentioned acetic acid solution and dissolve completely to 1000ml, the solution does not allow insoluble particles or insoluble matter to appear, and the mass volume concentration is made into 0.03g / ml chitosan-acetic acid solution.

[0052] 2. Vaccine Solution Preparation

[0053] Take 1ml of the solution-type human rabies purified vaccine with an activity unit of 10IU (this embodiment adopts two, each 0.5ml, 5IU) solution and add it to a 10ml measuring bottle, the preparation of ...

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Abstract

The present invention provides a spray for treating diseases caused by human papilloma virus and preparation method thereof. Said spray consists of 1 ml rabies vaccine for human use and 9 ml 0.01-0.03 g / ml chitosan-acetic acid solution, the preparation method of which comprises the preparation of chitosan-acetic acid solution and the preparation of vaccine solution.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a spray for treating diseases caused by human papillomavirus infection and its preparation. Background technique [0002] During the clinical use of purified human rabies vaccine (KI), it was found that after stimulating the body as a biological antigen, it can induce a strong immune response in the body (antigen-specific immunity; non-antigen-specific immunity), while the host's The immune response plays a very important role in controlling related diseases. A large number of literature research materials prove that the low immunity of the human body is closely related to the occurrence of cancer. Once the immunity of the body is low, various diseases can take advantage of the opportunity. Clinical data also prove that in the study of the relationship between tumor viruses and human diseases, only human papilloma virus (humanpapilloma virus, HPV) has the most clear relationshi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/205A61K9/12A61K47/36A61P31/20A61P15/00
CPCA61K9/0014A61K9/0034A61K9/12A61K39/12A61K39/205A61K2039/54A61K2039/541A61K2039/585A61P15/00A61P31/14A61P31/20A61P35/00C12N2760/20134
Inventor 孙介光孙雪然
Owner 孙介光
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