Method for preparing high-purity lactulose

A lactulose, high-purity technology, applied in the field of preparation of high-purity lactulose, can solve the problem of high cost, and achieve the effect of simple production method, continuous production method and high purity

Inactive Publication Date: 2011-09-14
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since both lactulose and lactose are disaccharides with the same molecular weight, column chromatography separation is generally required to achieve the differential separation of the two. The cost of industrial chromatographic equipment is relatively high, and it has not been widely used in the industrial production of functional sugars. It is also a bottleneck problem in the industrial expansion of high-purity lactulose.

Method used

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  • Method for preparing high-purity lactulose
  • Method for preparing high-purity lactulose

Examples

Experimental program
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Effect test

Embodiment 1

[0018] A preparation method of high-purity lactulose, comprising the following steps:

[0019] (1) Preparation of lactulose syrup: use 4.6 kg of lactose as raw material, boric acid and sodium hydroxide as catalyst, including 0.69 kg of sodium hydroxide and 0.805 kg of boric acid (at this time, the molar ratio of boric acid and lactose is 1:1, and sodium hydroxide The molar ratio to lactose is 1.35:1), added to 22.5 L of water and heated to 70 °C to catalyze the conversion of lactose into lactulose syrup. The obtained lactulose syrup only contains lactulose and monosaccharides, and does not contain lactose ;

[0020] (2) Activated carbon decolorization: Cool the reaction solution to 50 °C, adjust the pH value to 3.2, add activated carbon with a mass ratio of 1% to the solid content for decolorization, and keep stirring for 2 h;

[0021] (3) Nanofiltration purification: import the syrup into the nanofiltration material liquid tank, use the M 8 series nanofiltration membrane to ...

Embodiment 2

[0025] A preparation method of high-purity lactulose, comprising the following steps:

[0026] (1) Preparation of lactulose syrup: use 10.0 kg of lactose as raw material, boric acid and sodium hydroxide as catalyst, including 1.65 kg of sodium hydroxide and 2.0 kg of boric acid (at this time, the molar ratio of boric acid and lactose is 1.2:1, and sodium hydroxide The molar ratio to lactose is 1.5:1), added to 49.0 L of water and heated to 50 °C to catalyze the conversion of lactose into lactulose syrup, the obtained lactulose syrup only contains lactulose and monosaccharides, and does not contain lactose ;

[0027] (2) Activated carbon decolorization: Cool the reaction liquid to 50 °C, adjust the pH value to 3.2, add activated carbon with a mass ratio of 1.5% to the solid content for decolorization, and keep stirring for 1.0 h;

[0028] (3) Nanofiltration purification: import the syrup into the nanofiltration material liquid tank, use the M 8 series nanofiltration membrane t...

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Abstract

The invention relates to a method for preparing high-purity lactulose, which comprises the following steps of: preparing lactulose syrup, decolorizing by using activated carbon, performing nanofiltration and purification on the lactulose syrup, removing residual boric acid, and spray-drying to obtain high-purity lactulose powder, wherein in the nanofiltration and purification step, operating pressure is controlled to be between 15 and 25bar, the temperature is controlled to be between 20 and 50 DEG C, and a catalyst, salt and single sugar in the syrup are removed by a nanofiltration membrane in one step. The invention has the advantages that: the obtained lactulose has high purity of over 97.0 percent (based on total sugar), and the production method is simple, high-efficiency and energy-saving by a nanofiltration technology, and suitable for mass production and low in operating cost, and the production mode is continuous.

Description

technical field [0001] The invention relates to a method for preparing lactulose, in particular to a method for preparing high-purity lactulose combined with nanofiltration technology. Background technique [0002] Lactulose (also known as isomerized lactose, lactulose) is a stereoisomerized lactose, which is a combination of galactose and fructose β -1,4 glycosidically bonded disaccharides. Lactulose, as a raw material drug and functional food additive, has many excellent properties. However, the low purity of lactulose will limit its application in the fields of food and medicine. Although a lot of research on the preparation method of high-purity lactulose has been carried out at home and abroad, there is still no high-purity lactulose preparation method that is easy to industrialize and continuous. [0003] The lactose isomerization method is the main method for the industrial production of lactulose, such as figure 1 As shown in the traditional method section, acid,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/04C07H1/00
CPCY02P20/10
Inventor 杨瑞金张中华霄赵伟张文斌
Owner JIANGNAN UNIV
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