Pharmaceutical composition for treating atherosclerosis, and preparation method and application thereof
A technology of atherosclerosis and composition, applied in the field of pharmaceutical composition for the treatment of atherosclerosis, can solve the problem of inability to reverse or/and eliminate the radical cure of atherosclerotic plaque, the treatment method and its curative effect have not been reported To achieve the effect of preventing atherosclerosis and reducing the incidence of atherosclerosis
Inactive Publication Date: 2011-09-21
NANJING AGRICULTURAL UNIVERSITY
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Problems solved by technology
[0006] So far, the use of Ginkgo biloba extract for the treatment of atherosclerosis or the use of earthworm fibrinolytic enzyme for anticoagulant and thrombolytic therapy of coronary heart disease and angina pectoris cannot achieve the radical purpose of reversing or / and eliminating atherosclerotic plaque; And become pharmaceutical composition with these two kinds of crude drug prescriptions, the treatment method and its curative effect of AS are also not seen in the report
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0084] Take 900g of ginkgo leaf extract and 1,000,000 uku of earthworm fibrinolytic enzyme, mix evenly, add conventional auxiliary materials such as starch, dry at 40-45°C, granulate, and then compress to obtain tablets.
Embodiment 2
[0086] Take 200g of ginkgo biloba extract and 800,000 uku of earthworm fibrinolytic enzyme, mix evenly, add conventional auxiliary materials such as starch, dry at 40-45°C, granulate, wrap enteric-coated film, and then fill enteric-coated capsules to obtain enteric-coated capsules.
Embodiment 3
[0088] Get 600g of ginkgo biloba extract and 2,000,000uku of earthworm fibrinolytic enzyme and mix evenly, add conventional auxiliary materials and prepare honeyed pills according to conventional processes.
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The invention belongs to the field of biology, and discloses a pharmaceutical composition for treating atherosclerosis, and a preparation method and application thereof. The active components of the pharmaceutical composition comprise ginkgo leaf extract and earthworm fibrinolysin, wherein the dose ratio of the ginkgo leaf extract to the earthworm fibrinolysin is (200-900g):(800000-2700000uku). Proven by tests, after the pharmaceutical composition disclosed by the invention is used, compared with a single drug treatment group and a model group, the relative area of the aorta atheromatous plaque is notably reduced, macroscopic and microscopic pathological changes are the lightest, and the animal morbidity is the lowest. The levels of LDL (low density lipoprotein), TC (total cholesterol) and TG (triglyceride) of the pharmaceutical composition treatment group are notably reduced compared with the model group, and the level of HDL (high density lipoprotein) of the high-dose pharmaceutical composition group is notably raised. The pharmaceutical composition disclosed by the invention has two single drugs synergic in combined action property, has the effect of treating both principal and secondary aspects of disease on atherosclerosis, and is clinically proven especially by patients who have coronary heart disease and moderate and severe coronary artery stenosis.
Description
technical field [0001] The invention belongs to the biological field and relates to a pharmaceutical composition for treating atherosclerosis. Background technique [0002] Atherosclerosis (AS) is the common pathological basis of many cardiovascular and cerebrovascular diseases, and it is also the most common disease of the cardiovascular system, which seriously endangers human health. At present, AS presents a trend of high incidence and younger age in my country. For this common, frequently occurring and serious chronic disease, it is urgent and important to study drugs that are non-invasive, have no obvious toxic and side effects, have significant curative effect, and treat both symptoms and root causes. [0003] The pathogenesis of AS has not been fully elucidated, and studies have found that its occurrence is closely related to factors such as hyperlipidemia, peroxidative damage to the arterial intima, and increased blood coagulation. Aiming at these factors, people h...
Claims
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Login to View More IPC IPC(8): A61K38/48A61P9/10A61K36/16
Inventor 张治国张晓晓连桂芳
Owner NANJING AGRICULTURAL UNIVERSITY
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