Specific B cell epitope polypeptide of NS1 protein of encephalitis B virus and use thereof

A Japanese encephalitis virus and antigen epitope technology, applied in the field of molecular immunology, can solve problems such as affecting the diagnosis results, and achieve the effects of stable detection results, high antigen purity, and easy uniform quality
CN102206249AActive Publication Date: 2011-10-05HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Publication Date
2011-10-05

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Abstract

The invention discloses the sequence of a specific B cell epitope polypeptide of an NS1 protein of encephalitis B virus and the use of the epitope polypeptide in the diagnosis of encephalitis B virus and a screening method of specific B cell epitope polypeptide of NS1 protein of encephalitis B virus, and belongs to the field of molecular immunology. The amino sequence of the epitope polypeptide is represented by SEQ ID No.1 or SEQ ID No.2. The specific B cell epitope synthetic polypeptide of the JEV NS1 protein, the coupling antigen of the synthetic epitope polypeptide and the epitope fusion expression protein can be used for specifically detecting a JEV NS1 protein antibody generated in body which is immunized and infected. The epitope polypeptide can be used for diagnosis of JEV infection, evaluation on immunity effect and identification and diagnosis of immunity of inactivated vaccine and natural infection.
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Description

technical field

[0001] The present invention relates to antigenic epitope polypeptides, in particular to Japanese encephalitis virus JEV NS1 protein-specific B cell antigenic epitope polypeptides. The present invention also relates to the application of the antigenic epitope polypeptides in the diagnosis of Japanese encephalitis virus, which belongs to molecular immunization field of study. Background technique

[0002] Japanese encephalitis is an important mosquito-borne zoonotic disease caused by Japanese encephalitis virus (JEV). The virus was first isolated from the brain tissue of patients in Japan in 1953, so it is called Japanese encephalitis virus, and the disease caused by it is called Japanese encephalitis B in Japan. In my country, the virus was first isolated in 1940. In order to distinguish it from Japanese encephalitis, it was named Japanese encephalitis, or Japanese encephalitis for short. Worldwide, there are 30,000-50,000 JE cases every year, about 25%-30%...

Claims

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