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Application of penehyclidine hydrochloride in preparation of medicine for treating motion sickness

A technology for penehyclidine hydrochloride and motion sickness, which is applied in the field of medicine to achieve the effects of broad drug selection space, relieving motion sickness symptoms, and reducing the incidence of adverse reactions

Active Publication Date: 2011-10-19
JINZHOU AHON PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Penehyclidine hydrochloride is a new type of anticholinergic drug with selective M 1 , M 3 and N 1 , N 2 Receptor antagonism, has a strong anticholinergic effect on the central and peripheral, and has a strong anticholinergic effect on M 2 The receptor has no obvious effect. At present, the clinical pharmaceutical use of penehyclidine hydrochloride is mainly concentrated in the fields of pre-anesthesia medication, organophosphorus pesticide poisoning rescue medication, anti-shock and other fields. Motion sickness drug field

Method used

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  • Application of penehyclidine hydrochloride in preparation of medicine for treating motion sickness
  • Application of penehyclidine hydrochloride in preparation of medicine for treating motion sickness
  • Application of penehyclidine hydrochloride in preparation of medicine for treating motion sickness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Pharmacodynamic test of penehyclidine hydrochloride against motion sickness in animals

[0029] 1 Abstract Objective To evaluate the prevention and treatment effect of penehyclidine hydrochloride on motion sickness by animal experiments. Methods Reverse circle syndrome in rabbits induced by reversible cholinesterase inhibitors. Conclusion Penehyclidine hydrochloride has obvious anti-motion sickness effect, and the effective dose is significantly lower than that of phencyclonyl hydrochloride.

[0030] 2 materials

[0031] 2.1 Test drugs

[0032] Penehyclidine hydrochloride was synthesized by Chengdu Lisite Pharmaceutical Co., Ltd. with a purity of 99.5%. Paraoxon and isodipropylene glycol were purchased from Acros Company with a purity of more than 99%. Procaine was purchased from Beijing Yongkang Pharmaceutical Co., Ltd. .

[0033] control drug

[0034] Phencynonyl hydrochloride (Phencyclonyl hydrochloride tablets, Beijing Huasu Pharmaceutical Co., Ltd., ...

Embodiment 2

[0051] Example 2 Penehyclidine Hydrochloride Tablets Treated 60 Cases of Motion Sickness

[0052] Randomly select 60 cases of patients who have past medical history of repeated motion sickness and seasickness, and have no heart, liver, lung and blood system abnormalities, frequent headache, insomnia and other symptoms after physical examination, and are divided into three groups, respectively penehyclidine hydrochloride tablet group (1mg / Tablets), phencyclonyl hydrochloride tablet group (2 mg / tablet), vitamin B1 tablet (100 mg / tablet) group, take the medicine 30 minutes before taking the bus, and observe the patients after taking the medicine for 0.5-1 hour, 2-4 hours, 6 to 8 hours, the probability of motion sickness symptoms (dizziness, nausea, vomiting), and the occurrence of adverse reactions such as dry mouth, palpitation and heart palpitations are observed at the same time. The results are shown in Table 2 and Table 3 respectively:

[0053] Table 2 Comparison table of th...

Embodiment 3

[0060] Example 3 Penehyclidine Hydrochloride Patch Used to Relieve Motion Sickness Symptom Test

[0061] Randomly select 20 patients (10 males and 10 females) who have a past medical history of motion sickness and seasickness and have no heart, liver, lung and blood system abnormalities and frequent headaches and insomnia after physical examination. Neiguan point, penehyclidine hydrochloride patch (10mg / tablet), observe the symptoms of motion sickness (dizziness, nausea, vomiting) in 0.5 to 1 hour, 2 to 4 hours, and 6 to 8 hours after the patch is applied. The probability of adverse reactions such as dry mouth, palpitation and heart palpitations were observed at the same time. The results are shown in Table 4:

[0062] Table 4 The total effective rate of penehyclidine hydrochloride patch in relieving motion sickness symptoms

[0063]

[0064] It can be seen that the penehyclidine hydrochloride patch also has a very good therapeutic effect on alleviating motion sickness sym...

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Abstract

The invention discloses application of penehyclidine hydrochloride in preparation of a medicine for treating motion sickness; motion sickness is a joint name of train sickness, sea sickness, aviation sickness and other sickness caused by swinging, bumping, rotation, deceleration movement and the like due to various reasons. The medicine for treating motion sickness is tablets, granules, capsules or patches and other pharmaceutical preparations which are prepared by adopting the penehyclidine hydrochloride composition as a main component and adding pharmaceutically acceptable auxiliary components, wherein the weight ratio of the penehyclidine hydrochloride to the auxiliary components is 1: 1-1:400. According to the invention, the application field of the penehyclidine hydrochloride is widened, a novel medicine is provided for special group with motion sickness, the untoward effects and uncomfortableness brought to people by taking the conventional medicine for treating motion sickness are avoided; furthermore, the medicine is long in effective time, rapid in taking effect and smaller in dosage, and not only troubles caused by taking the medicine are reduced, but also the incidence of the untoward effects are also greatly reduced.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to the new pharmaceutical application of the compound penehyclidine hydrochloride, in particular to the application of penehyclidine hydrochloride in the preparation of medicines for treating motion sickness. Background technique [0002] Motion sickness is a general term for motion sickness, seasickness, airsickness, and diseases caused by various reasons such as shaking, turbulence, rotation, and accelerated motion. It is often caused by riding a car, boat, or aircraft. People began to study the pathogenesis of motion sickness disease for a long time, but so far, no thorough cure has been found, and generally only suitable anti-motion sickness drugs can be selected to relieve motion sickness symptoms. [0003] Prior Art (Peng Lijun, Yu Hanhua. Advances in pharmacological research on anti-motion sickness drugs, Chinese Journal of Hospital Pharmacy, Volume 24, No. 2, 2004) studies have show...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61P1/08
Inventor 朱登军
Owner JINZHOU AHON PHARM CO LTD
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