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Ultrasonic countercurrent extraction method of polyprenol

A polyprenol, countercurrent extraction technology, applied in the field of ultrasonic countercurrent extraction of polyprenol, ultrasonic extraction of polyprenol, can solve the problems of low purity of polyprenol, poor product quality, short extraction time, etc., to achieve Short extraction time, low solvent consumption and high extraction rate

Inactive Publication Date: 2011-10-19
ZHEJIANG FORESTRY ACAD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The polyprenol that this method makes has lower purity, and product quality is poorer
[0006] In summary, there is currently no method for extracting polyprenol that has short extraction time, low solvent consumption, high extraction rate, low energy consumption, good product quality, and is conducive to energy saving and emission reduction.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Gather 1Kg of ginkgo leaves as raw materials, and wash them with drinking water.

[0034] (2) Place 1 kg of ginkgo leaves washed with water as raw materials in an oven at 60° C. for 3 hours, and dry the washed ginkgo leaves to obtain dried ginkgo leaves.

[0035] (3) Grinding the dried ginkgo leaves and passing them through a 60-mesh sieve to obtain crushed materials. The particle diameters of the pulverized ginkgo leaves are all below 60 mesh.

[0036] (4) At a temperature of 50°C, under ultrasonic conditions with an ultrasonic frequency of 40KHz and a power of 400W, add 5Kg of petroleum ether to the crushed material, and then perform ultrasonic extraction on the mixture of petroleum ether and crushed material to obtain the extract. During the extraction process, petroleum ether and ginkgo leaves move in reverse, with a relative speed of 1m / h, and extract for 40min.

[0037] (5) Concentrate the extract under vacuum at a temperature of 50°C and a pressure of 0.01 b...

Embodiment 2

[0041] (1) Collect 50Kg of artificially cultivated southern yew leaves as raw materials, and wash them with drinking water.

[0042] (2) Spread out the washed yew leaves and expose them to the sun for 4 hours in the open air. Normally, they are exposed to the sun for 4 hours in summer. The lower the temperature, the longer the exposure time can be extended.

[0043] (3) Crush the dried yew leaves and pass through a 60-mesh sieve, so that the particle size of the crushed yew leaves is below 60 mesh.

[0044] (4) At a temperature of 55°C, with an ultrasonic frequency of 35KHz and an ultrasonic power of 300W, add 300Kg of a mixture of n-hexane and ethanol to the crushed yew leaves as an extraction solvent. The n-hexane and The volume ratio of ethanol is 5:1, the extraction solvent and the yew leaves move in reverse, the relative movement speed is 0.75m / h, and the extract is obtained by extracting for 120min.

[0045] (5) Put the extract at 60° C. under a vacuum of 0.01 bar, and ...

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Abstract

The invention relates to an ultrasonic countercurrent extraction method of polyprenol. At present, extraction methods of polyprenol with short extraction period, little solvent consumption and high extraction ratio do not exist. The invention successively comprises the following steps: (1) cleaning; (2) drying; (3) crushing; (4) putting crushed materials in a state with a temperature of 30 to 70 DEG C and an ultrasonic frequency of 20 to 60 KHz, and making the solvent move with the counter crushed materials with a relative velocity of 0.5 to 1.0 m / h; (5) carrying out vacuum concentration, cold separation, hydrolysis, phase separation, extraction, washing and reconcentration; (6) carrying out first column chromatography with a pressure of 0.5 to 2 bar to obtain crude polyprenol through collecting chromatography products at a wavelength of 215nm; and (7) carrying out second column chromatography with the pressure of 2 to 5 bar to obtain finished polyprenol through collecting the chromatography products at the wavelength of 215nm. The method has the advantages of short extraction period, little solvent consumption, high extraction ratio and the finished product purity of more than 90%.

Description

technical field [0001] The invention relates to a method for extracting polyprenol, in particular to a method for ultrasonic countercurrent extraction of polyprenol, which belongs to a technical process for ultrasonically extracting polyprenol in which materials and extractants move in reverse. Background technique [0002] Polyprenols (polyprenols) compounds are linear oligomers composed of 7 to 21 isopentene units, which have obvious functions of inhibiting tumors, anti-viruses, lowering blood sugar, protecting liver and hematopoiesis. Existing commonly used polyprenol extraction methods include solvent extraction, ordinary ultrasonic extraction and supercritical carbon dioxide extraction. These polyprenol extraction methods have problems such as low extraction rate and high energy consumption, which not only improves production The cost reduces the quality of polyprenol, and is not conducive to energy saving and emission reduction. [0003] The existing solvent extractio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C33/02C07C29/76B01D11/02B01J19/10
Inventor 王衍彬钱华于金慧刘本同
Owner ZHEJIANG FORESTRY ACAD
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