Medicinal composition for treating blood stasis and qi stagnation syndrome of primary liver cancer and preparation method thereof

Abstract

The invention discloses a medicinal composition for treating blood stasis and qi stagnation syndrome of primary liver cancer and a preparation method thereof. The preparation method is the improvement on a Jinlong capsule preparation process shown in the original pharmacopoeial standard WS3-158(Z-036)-2001Z. The improved raw material composition comprises fresh gecko, fresh little multibanded krait, fresh long-noded pit viper, beta-cyclodextrin and starch. The preparation process comprises the following steps of: chopping the fresh gecko, the fresh little multibanded krait and the fresh long-noded pit viper into comminuted meat, grinding into paste, adding water in an amount which is 4 times volume of the paste, performing homogenate, freezing for 24 hours at the temperature of -20 DEG C, taking out, thawing at the temperature of 25 DEG C, filtering, centrifuging filtrate at the rotation speed of 14,000rpm, sucking supernatant, ultrafiltering, taking filtrate, adding the beta-cyclodextrin and including, freeze-drying under vacuum, crushing to obtain fine particles, adding the starch, mixing uniformly, and drying at low temperature. The moisture absorption speed is low, the medicinal composition is easy to store for a long time, the ultrafiltration speed is high, the labor intensity is reduced, the production efficiency is high, energy sources can also be saved, and the quality of proteins is not affected.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition and a preparation method for treating primary liver cancer with blood stasis syndrome. Background technique [0002] The invention is an improvement based on the preparation process of the original Pharmacopoeia standard WS3-158(Z-036)-2001Z Jinlong capsule. There are following deficiencies in the original preparation process: [0003] 1. Only β-cyclodextrin is added to the raw medicine, which makes the raw medicine strong in moisture absorption, difficult to fill, and difficult to store for a long time; [0004] 2. In the homogenization operation, "add the same amount of water" to make the material thicker, the ultrafiltration speed is slow, and the labor intensity is increased; [0005] 3. The freezing temperature is -25°C, and the freezing time is prolonged, resulting in a large energy consumption; [0006] 4. The melting temperature is 37°C in a ...

AI Technical Summary

Problems solved by technology

[0003] 1. Only β-cyclodextrin is added to the raw medicine, which makes the raw medicine strong in moisture absorption, difficult to fill, and difficult to store for a long time;

[0004] 2. In the homogenization operation, "add the same amount of water" to make the material thicker, the ultrafiltration speed is slow, and the labor intensity is increased;

[0005] 3. The freezing temperature is -25°C, and the freezing time is prolonged, resulting in a large energy consumption;

[0006] 4. The melting temperature is 37°C in a water bath. Because the temperature is too high, it will affect the quality of the protein. If the temperature is too high, it is not convenient for production and operation, and consumes energy;

[0007] 5. The number of freezing and thawing is three times, which takes too long and consumes too much energy;

[0008] 6. The centrifugal speed is 8000 rpm, which cannot be separated instantly, the ultrafiltration speed is slow, the production efficiency is low, and the energy consumption is large

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