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Collagen temperature-sensitive hydrogel and preparation method thereof

A collagen and temperature-sensitive technology, applied in medical science, prosthesis, etc., can solve problems such as excessive speed, redness and swelling of the use site, allergic degradation, etc., and achieves long degradation time, weak immune rejection, and good gel formation. Effect

Active Publication Date: 2011-11-02
XIAN GIANT BIOGENE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, F Dalton of the United States has successively approved several products for soft tissue filling, the main components of which are bovine collagen, sodium hyaluronate, PMMA pellets, etc. Patients still have redness and swelling at the site of use, allergies and rapid degradation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Step 1: Dissolve animal-derived collagen with water for injection into a solution with a mass fraction of 1.0%;

[0039] Step 2: Set the degree of deacetylation to 80% and molecular weight to 10 5 Dalton's chitosan is dissolved into a solution with a mass fraction of 0.5% in dilute hydrochloric acid with a mass fraction of 0.5%;

[0040] Step 3: Dissolve β-glycerophosphate sodium with water for injection into a solution with a mass fraction of 20%;

[0041] Step 4: Mix the above three solutions at a volume ratio of 1:1:1, then stir at 0°C for 10 minutes to mix evenly, and adjust the pH to 7.4 at the same time;

[0042] Step 5: Fill the above mixture under aseptic conditions.

[0043] The hydrogel material of this example has been tested as follows:

[0044] Transfer the prepared mixture into a 1mL syringe and place it at 4°C for later use. Choose 50 excellent Kunming mice, male, weighing 25-30g, 25 as the experimental group and 25 as the negative control group. They are routinely...

Embodiment 2

[0051] Step 1: Dissolve animal-derived collagen with water for injection into a solution with a mass fraction of 2.5%;

[0052] Step 2: Set the degree of deacetylation to 85% and molecular weight to 2.5×10 5 Dalton's chitosan is dissolved into a solution with a mass fraction of 1.2% in dilute acetic acid with a mass fraction of 0.5%;

[0053] Step 3: Dissolve β-glycerophosphate sodium with water for injection into a solution with a mass fraction of 35%;

[0054] Step 4: Mix the above three solutions at a volume ratio of 2:2:1 and stir at 5°C for 15 minutes to mix evenly, and adjust the pH to 7.4 at the same time;

[0055] Step 5: Fill the above mixture under aseptic conditions.

[0056] The hydrogel material of this example has been tested as follows:

[0057] Transfer the prepared mixture into a 1mL syringe and place it at 4°C for later use. Choose 50 excellent Kunming mice, male, weighing 25-30g, 25 as the experimental group and 25 as the negative control group. They are routinely rai...

Embodiment 3

[0064] Step 1: Dissolve animal-derived collagen with water for injection into a solution with a mass fraction of 5.0%;

[0065] Step 2: Set the degree of deacetylation to 85% and the molecular weight to 5×10 5 Dalton’s chitosan is dissolved into a solution with a mass fraction of 2.0% with dilute lactic acid with a mass fraction of 1%;

[0066] Step 3: Dissolve β-glycerophosphate sodium with water for injection into a solution with a mass fraction of 50%;

[0067] Step 4: Mix the above three solutions in a volume ratio of 3:3:1 and then stir at 5°C for 20 minutes to mix evenly, and at the same time adjust the pH to 7.4;

[0068] Step 5: Fill the above mixture under aseptic conditions.

[0069] The hydrogel material of this example has been tested as follows:

[0070] Transfer the prepared mixture into a 1mL syringe and place it at 4°C for later use. Choose 50 excellent Kunming mice, male, weighing 25-30g, 25 as the experimental group and 25 as the negative control group. They are routin...

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PUM

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Abstract

The invention relates to a collagen temperature-sensitive hydrogel and a preparation method thereof Soft tissue filling materials utilized in the existing plastic and beauty treatment industry have the problems of hardening, production of phyma, too fast absorption speed, and induction of chronic inflammation. American F Dalton approves successively multiple products for soft tissue filling, and main components of the products comprise bovine collagen, hyaluronic acid sodium, polymethyl methacrylate (PMMA) globules and the like. The products have good effects but can still produce cases of redness and allergy of a used position and too fast absorption. In the invention, collagen solution, chitosan acid or hyaluronic acid, and beta-sodium glycerophosphate solution are mixed according to a volume ratio of (1 to 3): (1 to 5): (1 to 2), then are stirred well at a temperature of 0 to 15 DEG C for 10 to 30 minutes and are adjusted to a pH of 7.4 to form temperature-sensitive hydrogel. The temperature-sensitive hydrogel has the advantages of good gel forming property at a temperature of 37 DEG C, gel forming time within 10 minutes, good mechanical strength, long degradation time, low immunological rejection, and favorable safety and effectiveness.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to a collagen temperature-sensitive hydrogel and a preparation method thereof. Background technique [0002] In the plastic and cosmetic industry, soft tissue filling materials are needed to remove wrinkles, improve facial contours, fill in depressed scars or lips, and repair injured tissues. People have successively studied the use of materials such as white wax, fat transplantation, silicone resin, and gel implants. For soft tissue plastic surgery, clinical applications have found that there are problems such as sclerosis, tumor-like lumps, rapid absorption, and chronic inflammation. In recent years, F Dalton in the United States has successively approved several products for soft tissue augmentation. The main ingredients are bovine collagen, sodium hyaluronate, PMMA pellets, etc., which have achieved good results, but for some applications Patients still have redness, s...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L89/00C08L5/08A61L27/24A61L27/20A61L27/52
Inventor 范代娣段志广马晓轩严建亚
Owner XIAN GIANT BIOGENE TECH CO LTD
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