Compound acrivastine sustained release tablets, and preparation method thereof

A technology of atorvastatin and sustained-release tablets, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problems of poor patient tolerance and low bioavailability, and achieve less adverse reactions, Tolerance-improving, action-modifying effect

Active Publication Date: 2011-11-23
ANHUI YONSENT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The weak point of the compound preparation reported at present is that what the compound preparation of Avastin and pseudoephedrine hydrochlorid

Method used

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  • Compound acrivastine sustained release tablets, and preparation method thereof
  • Compound acrivastine sustained release tablets, and preparation method thereof
  • Compound acrivastine sustained release tablets, and preparation method thereof

Examples

Experimental program
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Embodiment Construction

[0039] specific implementation plan

[0040] The formula and process of compound Avastin sustained-release tablets are as follows:

[0041] ① Prescription

[0042] Avastin: 16g

[0043] Pseudoephedrine hydrochloride: 120g

[0044] Hypromellose K4M: 40g

[0045] Hydroxypropyl methylcellulose (100mPa.s): 20g

[0046] Lactose: 100g

[0047] Magnesium stearate: 2g

[0048] SiO 2 : 2g

[0049] 70% ethanol: appropriate amount,

[0050] The above prescription ingredients were made into 1000 tablets.

[0051] Preparation Process

[0052] (1) Protect from light, take each raw and auxiliary material according to the prescription, and set aside;

[0053] (2) Avastatin bulk drug, pseudoephedrine hydrochloride, and lactose are respectively passed through a 100-mesh sieve and fully mixed uniformly by the method of equal increment;

[0054] (3) Add hydroxypropyl methylcellulose K4M and hydroxypropyl methylcellulose (100mPa.s) to the above-mentioned mixed medicinal powder and mix ...

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Abstract

The invention relates to compound acrivastine sustained release tablets, which are prepared from formulated raw materials of, by mass: 14 to 18 parts of acrivastine, 118 to 122 parts of pseudoephedrine hydrochloride, 38 to 42 parts of hydroxypropyl methylcellulose K4M, 18 to 22 parts of hydroxypropyl methylcellulose (100mPa.s), 98 to 102 parts of lactose, 1 to 3 parts of magnesium stearate, and 1to 3 parts of SiO2. The preparation method comprises the steps that: the effective components acrivastine and pseudoephedrine hydrochloride, and the filling material are weighed, sieved and mixed; the framework material hydroxypropyl methylcellulose and an adhesive are added to the mixture; a soft material is prepared and sieved, such that wet granules are prepared; the granules are dried and shaped; a lubricant is added to the granules; all the materials are well mixed and are compressed into tablets according to certain requirements; the tablets are packed, such that finished products are obtained. Compared to common tablets, the sustained release tablets provided by the invention has advantages of long functioning duration, which is 12 hours; mild function; slow release; and less and light adverse reaction.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a compound avastatin sustained-release tablet and a preparation method thereof. Background technique [0002] Avastin is a pyrrole amine antihistamine developed by Glaxo-Wellcome in the UK. Its capsule formulation was first launched in the UK in August 1988 under the trade name Semprex. In 1993, Avastin capsules were approved to go on the market in China, and obtained administrative protection in 1993. In 2001, the administrative protection of this variety was terminated, and its trade name was Xinminle. [0003] Compound Avastin Capsules is a compound preparation of 8 mg of Avastin and 60 mg of pseudoephedrine hydrochloride. The new antihistamine drug Avastin in this product has an anti-allergic effect, while β 2 The receptor agonist pseudoephedrine hydrochloride can quickly relieve nasal congestion and allergic symptoms, so it has an incomparable and obvious advantage. In...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61K31/137A61K9/24A61P11/02
Inventor 夏运喜代俊伟
Owner ANHUI YONSENT PHARMA
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