Preparation of doxorubicin hydrochloride nanoliposome preparation

A nano-liposome and doxorubicin hydrochloride technology, applied in liposome delivery and other directions, can solve the problems of difficult chemotherapeutic drugs, easy systemic distribution to cause systemic side effects, etc., to reduce the dosage and facilitate large-scale Production, the effect of prolonging the half-life

Inactive Publication Date: 2012-11-07
中南大学肝胆肠外科研究中心 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, preparing doxorubicin into a drug with a particle size of 80-100nm, and then encapsulating it in liposomes can overcome the disadvantages of conventional chemotherapy, that it is difficult for chemotherapy drugs to reach an effective concentration inside the tumor, and the systemic distribution is easy to cause systemic toxic side effects.

Method used

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  • Preparation of doxorubicin hydrochloride nanoliposome preparation
  • Preparation of doxorubicin hydrochloride nanoliposome preparation
  • Preparation of doxorubicin hydrochloride nanoliposome preparation

Examples

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Embodiment 1

[0024] A doxorubicin hydrochloride nanoliposome provided by the invention is achieved through the following measures.

[0025] a Alcohol injection-pH gradient method:

[0026] Prescription: Adriamycin Acid 1.0g

[0027] Yolk Lecithin 10.0g

[0028] Cholesterol 5.0g

[0029] Ethanol 200mL

[0030] Vitamin E 0.25g

[0031] Citric acid 32.0g

[0032] Disodium hydrogen phosphate 154.0g

[0033] Tween-80 10.0g

[0034] Glucose 50.0g

[0035] Water for injection 1000mL

[0036] The preparation process is as follows:

[0037] Egg yolk lecithin, cholesterol, vitamin E, and emulsifier are dissolved in absolute ethanol to form a lipid solution, and doxorubicin hydrochloride is dissolved in citric acid solution. 2 Standby, under the condition of high-speed stirring, use an injection needle to inject the lipid solution into the citric acid solution containing doxorubicin hydrochloride, wash the beaker with hot ethanol, inject...

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Abstract

The invention relates to the field of medicinal preparations, in particular to a preparation method for a nanoliposome preparation of doxorubicin hydrochloride or doxorubicin. The preparation mainly comprises doxorubicin, egg yolk lecithin, cholesterol, an antioxidant, a buffer, sugar, injection water and the like. A preparation process comprises steps of preparation of blank liposome and doxorubicin nanoliposome, a process optimization step and the like. Freeze-dried powder prepared by the invention has high entrapment efficiency, high stability and a simple and practical preparation process.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a method for preparing doxorubicin hydrochloride or nano liposomes of doxorubicin. Background technique [0002] The molecular structural formula of doxorubicin is as follows: [0003] [0004] Doxorubicin (hereinafter referred to as DOX), also known as daunorubicin, oxybutamycin, and doxorubicin, is an anthracycline anti-malignant tumor antibiotic commonly used in clinic, with broad anti-tumor spectrum, strong activity and good curative effect. Its mechanism of action is mainly that DOX molecules intercalate into DNA and inhibit the synthesis of nucleic acids. [1] . DOX can produce a wide range of biochemical effects on the body, so it is widely used in the treatment of acute leukemia, non-Hodgkin's lymphoma, breast cancer, small cell lung cancer, gastric cancer, liver cancer, ovarian cancer and sarcoma and other malignant tumors [2] . However, after intravenous...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127
Inventor 龚连生张阳德何剪太张浩伟汪建荣刘殿奎周艳琴
Owner 中南大学肝胆肠外科研究中心
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