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Preparation method of taste-masking slow-release allicin composite microcapsules

An allicin and slow-release technology, which is applied in the field of microcapsule preparation, can solve the problems of intramuscular injection pain, short biological half-life, and inconvenience of intravenous injection, and achieve the effects of improving sustained-release performance, encapsulation efficiency, and drug loading

Inactive Publication Date: 2011-12-07
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chemical properties of allicin are unstable, and it is easy to decompose when it encounters heat and alkali, and it is irritating to the human gastrointestinal mucosa. The peculiar smell of garlic makes it difficult for patients to accept

Method used

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  • Preparation method of taste-masking slow-release allicin composite microcapsules

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Suspend 2 g of attapulgite in 100 mL of 0.5 % (w / v) CTAB solution, stir at 70 °C for 8 h, then filter and wash with suction, no bromide ions can be detected in the washing liquid, dry at 105 °C, and grind for 200 mesh sieve to obtain organic attapulgite; dissolve 1.0 g of allicin in 8 mL of absolute ethanol, add 2.0 g of Sodium alginate solution 100 mL was dispersed at room temperature for 15 min at high speed to obtain a uniform suspension; the suspension was dropped into 2% (w / v) calcium chloride solution with a constant flow pump at a flow rate of 2.2 rpm, Cross-link for 30 min to obtain gel microcapsules, filter with suction, wash the calcium ions on the surface of the gel microcapsules, transfer to 1% (w / v) chitosan solution with a molecular weight of 600,000 for coating for 2 h, filter , washed to obtain uniform and smooth spherical microcapsules, vacuum-dried to constant weight at 40°C to obtain allicin composite microcapsules.

Embodiment 2

[0019] Suspend 1 g of attapulgite in 100 mL of 0.1 % (w / v) CTAB solution, stir at 60 °C for 12 h, filter and wash with suction, no bromide ions can be detected in the washing solution, dry at 105 °C, and grind for 200 Mesh sieve to obtain organic attapulgite; dissolve 1.0 g of allicin in 5 mL of absolute ethanol, add 1.0 g of organic attapulgite in a 100 mL round-bottomed flask, mix well, evaporate to dryness, add 2% (w / v) seaweed Sodium chloride solution 25 mL, high-speed dispersion at room temperature for 15 min to obtain a uniform suspension; use a constant flow pump to drop the suspension into 2% (w / v) calcium chloride solution at a flow rate of 2.2 rpm, cross-linked 10 min, get the gel microcapsules, filter with suction, wash the calcium ions on the surface of the gel microcapsules, transfer to a 2% (v / v) chitosan solution with a molecular weight of 500,000, cover the film for 1 h, filter, and wash , to obtain uniform and smooth spherical microcapsules, vacuum-dry at 40 ℃...

Embodiment 3

[0021] Suspend 6 g of attapulgite in 200 mL of 1.0% (w / v) CTAB solution, stir at 80°C for 6 h, filter and wash with suction, no bromide ions can be detected in the washing solution, dry at 105°C, and grind for 200 Mesh sieve to obtain organic attapulgite; dissolve 1.0 g of allicin in 10 mL of absolute ethanol, add 4.0 g of organic attapulgite in a round bottom flask, mix well, evaporate to dryness, add 2 % (w / v) alginic acid Disperse 800 mL of sodium solution at room temperature for 15 minutes at high speed to obtain a uniform suspension; drop the suspension into 2% (w / v) calcium chloride solution with a constant flow pump at a flow rate of 2.2 rpm, and crosslink 60 min, get the gel microcapsules, suction filter, wash the calcium ions on the surface of the gel microcapsules, transfer to a 0.5% (v / v) chitosan solution with a molecular weight of 700,000 for coating for 3 h, filter, wash, Uniform and smooth spherical microcapsules were obtained, and vacuum-dried at 40 °C to const...

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Abstract

The invention discloses a method for preparing odor masking sustained-release garlicin composite micro-capsules. In the method, a garlicin / organic attapulgite complex serving as a capsule core is combined with sodium alginate to obtain a complex, and sodium alginate / chitosan micro-capsules are prepared from the obtained complex in a complex coacervation method. In the method, odor is masked and the medicine carrying capacity and envelop rate of the micro-capsules are improved by utilizing the adsorptive power and appetency of organic attapulgite on garlicin; gastric mucosae are protected against the irritation of the garlicin by utilizing the pH dependence of calcium alginate and the protective effect of attapulgite mucosae, and the micro-capsules become enteric medicine carrier materialsunder the synergistic action of the garlicin and the attapulgite on germs in intestinal tracts. In addition, the release of medicines in the micro-capsules is retarded by utilizing the detention effect of the attapulgite on the garlicin and the sustained-release performance of chitosan to improve the sustained-release performance of the micro-capsules. The preparation method is simple and environment-friendly, and can be used for sustained-release carrier materials of various medicines.

Description

technical field [0001] The invention relates to a preparation method of a microcapsule, in particular to a preparation method of a taste-masking slow-release allicin composite microcapsule. Background technique [0002] As we all know, allicin is the main active ingredient in garlic, and its chemical structure is dithiodipropylene (DATS), which has broad-spectrum antibacterial, antiviral, blood pressure lowering, blood fat lowering, prevention and treatment of middle-aged and elderly cardiovascular diseases and coronary heart diseases The role of anti-cancer and weight loss, and also has a variety of effects, domestic production can be artificially synthesized. However, the chemical properties of allicin are unstable, and it is easy to decompose when it encounters heat and alkali, and it is irritating to the human gastrointestinal mucosa. The peculiar smell of garlic makes it difficult for patients to accept. Therefore, it is an effective way to improve the curative effect...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/105A61K47/36A61P3/04A61P3/06A61P9/10A61P9/12A61P31/04A61P31/12A61P35/00
Inventor 吴洁金叶玲陈静蒋金龙
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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