Method for preparing heartleaf houttuynia herb injection

A kind of Houttuynia cordata injection and fishy technology, which is applied in the directions of medical preparations, pharmaceutical formulations, plant raw materials, etc. containing active ingredients, to achieve the effects of improving drug safety and reducing the effect of ruptured cell membranes.

Active Publication Date: 2013-08-28
HUNAN ZHENGQING PHARM GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In Ministry Standard WS 3 -The [Preparation Method] item of Houttuynia cordata injection in B-3264-98 stipulates that the addition amount of polysorbate 80 is 0.5%, but the safety research shows that polysorbate 80 has a strong effect of breaking the cell membrane and causing Irritation, hemolysis and histamine release (sensitization)

Method used

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  • Method for preparing heartleaf houttuynia herb injection
  • Method for preparing heartleaf houttuynia herb injection
  • Method for preparing heartleaf houttuynia herb injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0189] (1) According to the mass ratio of 1:2, take 2000 kilograms of the mixture of fresh Houttuynia cordata aerial part and Houttuynia cordata underground part, carry out steam distillation, collect 2000 liters of initial distillate, and then redistill, collect 1000 liters of heavy distillate ;

[0190] (2) Add weight / volume ratio to polysorbate 80 of 2.5‰ in heavy distillate, stir for 10 minutes and dissolve, add 7 kilograms of sodium chloride, stir for 10 minutes and dissolve, adjust with 10% citric acid solution The pH value is 5.0-6.0;

[0191] (3) Filter the double distillate after the treatment in step (2) with 0.45 μm and 0.22 μm filter elements, potting, and sterilizing at 115° C. for 32 minutes to obtain Houttuynia cordata injection.

Embodiment 2

[0193] (1) According to the mass ratio of 1:3, take 2000 kilograms of the mixture of fresh Houttuynia cordata aerial part and Houttuynia cordata underground part, carry out steam distillation, collect 1500 liters of initial distillate, carry out redistillation again, collect 850 liters of heavy distillate ;

[0194] (2) Add weight / volume ratio to polysorbate 80 of 2.9‰ in the double distillate, stir for 8 minutes to dissolve, add 7 kilograms of sodium chloride, stir for 10 minutes to dissolve, adjust with 10% citric acid solution The pH value is 5.0-6.0;

[0195] (3) Filter the double distillate after the treatment in step (2) with 0.45 μm and 0.22 μm filter elements, potting, and sterilizing at 115° C. for 32 minutes to obtain Houttuynia cordata injection.

Embodiment 3

[0197] (1) According to the mass ratio of 1: 1.5, take 2000 kilograms of the mixture of the aerial part of Houttuynia cordata and the underground part of Houttuynia cordata, carry out steam distillation, collect 2500 liters of initial distillate, carry out redistillation again, collect 1300 liters of heavy distillate ;

[0198] (2) Add weight / volume ratio to polysorbate 80 of 2.6‰ in the double distillate, stir for 15 minutes to dissolve, add 7 kilograms of sodium chloride, stir for 10 minutes to dissolve, adjust with 10% citric acid solution The pH value is 5.0-6.0;

[0199] (3) Filter the double distillate after the treatment in step (2) with 0.45 μm and 0.22 μm filter elements, potting, and sterilizing at 115° C. for 32 minutes to obtain Houttuynia cordata injection.

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Abstract

The invention discloses heartleaf houttuynia herb injection and a preparation method thereof. In the heartleaf houttuynia herb injection prepared by the method, production links and production parameters are defined and refined, and the using amount of polysorbate 80 is reduced on the basis of the legal departmental standard. Different batches of the prepared heartleaf houttuynia herb injection are stable and uniform, the effect of cell membrane cracking caused by the polysorbate 80 is reduced, irritation, haemolysis and histamine release are reduced, and the safety of administration is improved.

Description

Technical field: [0001] The invention relates to a method for preparing an injection, in particular to a method for preparing Houttuynia injection by using the whole herb of Houttuynia cordata. Background technique [0002] Houttuynia cordata is the rooted whole plant of Houttuynia cordata Thunb., a perennial herbaceous plant of the family Tribaceae, also known as Pleurotus chinensis, Purple Houttuynia, Pig Nostril, Jiujielian, etc. Its fresh plants have a pungent fishy smell after being broken , widely distributed in the central, southeast and southwest provinces of my country, especially in Hunan, Hubei, Sichuan, Jiangsu and other provinces. Houttuynia cordata has the effects of clearing heat and detoxifying, eliminating carbuncle and draining pus, diuresis and treating stranguria. It is clinically used for lung abscess and vomiting of pus, phlegm-heat wheezing and coughing, hot dysentery, hot stranguria, carbuncle and sore. Studies have shown that Houttuynia cordata conta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/78A61K47/34A61P11/00A61P13/00A61P17/02
Inventor 吴飞驰仇萍彭祖仁滕健李苏翠龙宪军
Owner HUNAN ZHENGQING PHARM GRP CO LTD
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