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Use of salvianolic acid a in the preparation of medicines for treating or preventing cardiomyocyte apoptosis

A technology of cardiomyocyte apoptosis and salvianolic acid, which can be used in drug combinations, pharmaceutical formulations, cardiovascular diseases, etc., can solve the problems of cardiomyocyte apoptosis and its mechanism that have not been reported yet

Inactive Publication Date: 2011-12-14
无锡特吉特药物研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although there have been many reports of salvianolic acid A anti-myocardial ischemia animal experiments, the research on its inhibition of cardiomyocyte apoptosis and its mechanism has not been reported yet.

Method used

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  • Use of salvianolic acid a in the preparation of medicines for treating or preventing cardiomyocyte apoptosis
  • Use of salvianolic acid a in the preparation of medicines for treating or preventing cardiomyocyte apoptosis
  • Use of salvianolic acid a in the preparation of medicines for treating or preventing cardiomyocyte apoptosis

Examples

Experimental program
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Effect test

experiment example 1

[0019] Experimental example 1: Salvianolic acid A inhibits H 2 o 2 Induced Apoptosis Experiment of Rat Cardiomyocytes H9c2

[0020] 1. Experimental materials

[0021] 1 cell line

[0022] Rat cardiomyocytes (H9c2): Cell Bank of Shanghai Institute of Cells, Chinese Academy of Sciences

[0023] 2 Drugs and reagents

[0024] Test sample: salvianolic acid A, provided by Shandong Target Drug Research Co., Ltd., properties, this product is yellow powder.

[0025] DMEM powder: Invitrogen Corporation

[0026] Trypsin: amresco

[0027] Tetramethylazolium salt (MTT): amresco

[0028] Dimethyl sulfoxide: Tianjin Kemiou Chemical Reagent Co., Ltd., batch number: 080228

[0029] 30% hydrogen peroxide: Tianjin Tianda Chemical Experimental Factory, batch number: 080503

[0030] Fetal bovine serum: Hangzhou Sijiqing Bioengineering Materials Co., Ltd., batch number: 081206

[0031] Penicillin-Streptomycin: Biyuntian Biotechnology Research Institute

[0032] Superoxide Dismutase (SOD)...

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Abstract

The invention relates to the technical field of medicine, and relates to the use of salvianolic acid A in preparing a drug for treating and / or preventing cardiomyocyte apoptosis. In particular, the use of salvianolic acid A in the preparation of a medicament for preventing or treating myocardial ischemia-reperfusion injury caused by thrombolysis, percutaneous coronary intervention or coronary artery bypass surgery and the like.

Description

Technical field: [0001] The present invention relates to a new medical application of salvianolic acid A, in particular to its application in the preparation of drugs for treating and / or preventing cardiomyocyte apoptosis. Background technique: [0002] Cardiovascular disease is the number one killer that seriously threatens human health. The number of people who die from cardiovascular disease in the world is as high as 15 million every year. The mortality rate of cardiovascular disease in my country also accounts for about 50% of the total mortality rate of diseases. In atherosclerosis, hypertension, cardiomyopathy, myocardial ischemia-reperfusion injury and other common clinical cardiovascular diseases, cardiomyocyte apoptosis plays an important role in the pathophysiological changes. It has been confirmed that cardiomyocytes undergo apoptosis under the induction of various stimulating factors, and apoptotic cardiomyocytes participate in the pathogenic process, which is t...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P9/00A61P9/10A61P39/06
Inventor 刘珂范华英刘军锋张爱红杨明艳
Owner 无锡特吉特药物研究有限公司
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