A kind of biomineralization material and its preparation method and application

A biomineralization and polymer technology, applied in the direction of dental preparations, digestive system, drug combination, etc., can solve the problems of easy shedding, mismatching mechanical properties, poor long-term effect, etc., and achieve easy industrial production, strong adsorption, and realization The effect of industrial production

Inactive Publication Date: 2011-12-28
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the materials that simulate the remineralization of dentin induced by organic matrix include biomacromolecules, liposomes, vesicles, monomolecular membranes, self-assembled membranes, micelles, gels and other systems, but there is a certain degree of curative effect in the application process. Instability, poor long-term effect, easy to fall off, and the mechanical properties of filling materials do not match the surrounding normal tissues. Therefore, the reconstruction of the hard tissue structure and mechanical properties of mineral teeth is a problem that needs to be solved.

Method used

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  • A kind of biomineralization material and its preparation method and application
  • A kind of biomineralization material and its preparation method and application
  • A kind of biomineralization material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The processing steps of the present embodiment are as follows:

[0037] (1) Synthesis of 3-generation polyamide-amine dendrimers with carboxyl groups

[0038] ① Prepare the first solution

[0039] With 3 generations of polyamide-amine dendrimers (G3.0PAMAM) as solute, with dimethyl sulfoxide (DMSO) as solvent, the proportioning of described solute and solvent is that the concentration of solute is 50 grams per liter of solution. limit, the solute is dissolved in the solvent at normal pressure and room temperature to form the first solution;

[0040] ② Prepare the second solution

[0041] With succinic anhydride (SAH) as solute, with dimethyl sulfoxide (DMSO) as solvent, the proportioning of described solute and solvent is limited to 300 grams per liter of solution with the concentration of solute, under normal pressure, room temperature will The solute is dissolved in the solvent to form a second solution;

[0042] ③Synthesis

[0043] The first solution is 48.78 mi...

Embodiment 2

[0049] The processing steps of the present embodiment are as follows:

[0050] (1) Synthesis of 5th generation polyamide-amine dendrimers with carboxyl groups

[0051] ① Prepare the first solution

[0052] With 5 generations of polyamide-amine dendrimers (G5.0PAMAM) as solute, with dimethyl sulfoxide (DMSO) as solvent, the proportioning of described solute and solvent is that the concentration of solute is 100 grams per liter of solution. limit, the solute is dissolved in the solvent at normal pressure and room temperature to form the first solution;

[0053] ② Prepare the second solution

[0054] With succinic anhydride (SAH) as solute, with dimethyl sulfoxide (DMSO) as solvent, the proportioning of described solute and solvent is that the concentration of solute is 600 grams per liter of solution as limit, under normal pressure, room temperature will The solute is dissolved in the solvent to form a second solution;

[0055] ③Synthesis

[0056] The first solution is 53.2...

Embodiment 3

[0062] 1. Materials and methods

[0063] 1.1 Materials

[0064] 1.1.1 The specification is HA / M30 hydroxyapatite powder, the water content is less than 0.1%.

[0065] 1.1.2 Reagents

[0066] The end group is the 3rd generation polyamide-amine dendrimers of carboxyl groups (abbreviated as CP in this embodiment, its preparation method sees the step (1) of above-mentioned embodiment 1);

[0067] The biomineralized material prepared in Example 1 above (abbreviated as AP in this example);

[0068] Deionized water;

[0069] PBS buffer, pH 7.4, was purchased from Chengdu Baoxin Biotech.

[0070] 1.2 Method

[0071] 1.2.1 Use deionized water as solvent

[0072] Set CP group and AP group, each group contains 5 parallel samples. Prepare CP and AP respectively into deionized aqueous solutions with a concentration of 1 mg / mL, respectively fill 5 mL of CP aqueous solution and 20 mg of hydroxyapatite powder into 5 test tubes of the CP group and stir for 20 minutes to mix evenly. Put...

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Abstract

A biomineralization material of the invention has a structural formula shown as below. In the structural formula, one part is a polyamide-amine dendritic polymer with an end group of carboxyl, and the ALN is an Alendronate sodium medical unit. The preparation method of the biomineralization material of the invention includes the following steps: (1) synthesizing polyamide-amine dendritic polymer with the end group of carboxyl; (2) partially activating the polyamide-amine dendritic polymer; (3) synthesizing the biomineralization material. According to experiments, the biomineralization material of the invention has both functions of absorbing hydroxy apatite and inducing re-mineralization of the hydroxy apatite, and can be used as a derivant for dentin in-situ re-biomineralization.

Description

technical field [0001] The invention relates to a biomineralization material capable of adsorbing hydroxyapatite (HAP) and inducing remineralization of hydroxyapatite, a preparation method and application thereof. Background technique [0002] With the improvement of people's awareness of oral health, the demand for clinical technology to treat dental diseases caused by demineralization has increased rapidly. Organic matrices such as enamel matrix protein and dentin phosphoprotein in the human body play an important role in the balance process of tooth demineralization and remineralization. It has become an important means. At present, the materials that simulate the remineralization of dentin induced by organic matrix include biomacromolecules, liposomes, vesicles, monomolecular membranes, self-assembled membranes, micelles, gels and other systems, but there is a certain degree of curative effect in the application process. Instability, poor long-term effect, easy to fall...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/663A61K6/00A61P1/02
Inventor 李建树吴铎李佳慧辛剑宇林再富
Owner SICHUAN UNIV
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