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Thymol nano-medicament and preparation method thereof

A technology of thymol and nano-drug, applied in the field of medicine, can solve the problems of thymol being insoluble in water, poor stability, etc., and achieve the improvement of stability, skin permeability and drug bioavailability, good dispersion, and bioavailability. high effect

Inactive Publication Date: 2012-01-25
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the defects and deficiencies in the prior art, the present invention makes thymol into a nanoemulsion, which greatly enhances the efficacy of thymol, and also solves the shortcomings of thymol being difficult to dissolve in water and having poor stability.

Method used

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  • Thymol nano-medicament and preparation method thereof
  • Thymol nano-medicament and preparation method thereof
  • Thymol nano-medicament and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0055] 1) Weigh thymol 0.1g, 0.1g, 3g, 0.5g, distilled water 6.3g, set aside;

[0056] 2) Add thymol to ethyl oleate and stir evenly;

[0057] 3) Add the solution prepared in step 2) into absolute ethanol and stir to dissolve completely, then add EL-40 into it, and stir evenly;

[0058] 4) Slowly add distilled water to the solution prepared in step 3) and stir thoroughly at 20°C to 25°C until a clear, transparent, yellow or colorless and transparent thymol nanomedicine with low viscosity and fluidity is formed.

Embodiment 2

[0060] 0.2 g of thymol, 0.02 g of isopropyl myristate, 0.02 g of ethyl acetate, 3 g of RH-40, 0.5 g of absolute ethanol, 0.3 g of 1,2-propylene glycol, and 5.96 g of distilled water.

Embodiment 3

[0062] Thymol 0.5g, olive oil 0.05g, isopropyl myristate 0.05g, Tween-80 3.5g, Tween-60 0.5g, absolute ethanol 0.5g, ethylene glycol 0.5g, distilled water 4.4g.

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Abstract

The invention discloses a thymol nano-medicament, which is prepared from the following raw materials in percentage by mass: 0.1-5 percent of thymol, 0.1-5 percent of oil phase, 20-40 percent of surfactant, 4-20 percent of cosurfactant and the balance of distilled water, wherein the total mass percentage of the raw materials is 100 percent. The thymol nano-medicament has the advantages of high thermodynamic stability, high storage stability, non-delamination by long-time standing, high liquid drop dispersion degree and high bioavailability, and can be used for safely and effectively treating dermatozoiasis.

Description

technical field [0001] The invention belongs to the field of medicine, relates to a new dosage form of an acaricidal drug, in particular to a preparation method of a stable and transparent thymol nano-medicine. Background technique [0002] Thymol (thymol), also known as thymol, is a monoterpene phenol, a derivative of cymene, mainly derived from thyme plants, and is the main component of thyme volatile oil. It has a wide range of bactericidal, antiseptic, antioxidant, It has anti-inflammatory, expectorant, and mite-removing activities, and it has also been found to have obvious anti-tumor effects in recent years. Thymol is a white to light yellow crystalline powder at room temperature, slightly soluble in water, easily soluble in organic solvents, its properties are extremely unstable during the production and storage of traditional dosage forms, and it is easy to lose and affect the efficacy of the drug. Most of the medicines currently on the market for the treatment of s...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/05A61P17/00A61P33/14
Inventor 欧阳五庆刘梅雪欧阳伸雨
Owner NORTHWEST A & F UNIV
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