Unlock instant, AI-driven research and patent intelligence for your innovation.

Antofloxacin capsule preparation and preparation method thereof

A kind of technology of Floxacin and preparation, which is applied in the field of Antofloxacin capsule preparation and its preparation, can solve the problems such as the influence of drug dissolution, and achieve the effect of good dissolution rate, stable finished preparation and simple steps

Inactive Publication Date: 2012-02-01
ANHUI GLOBAL PHARM CO LTD
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pregelatinized starch has good fluidity and plays a very good role in improving the fluidity of powders. However, it is easy to form a colloidal solution with strong viscosity when it meets water, which will have a great impact on the dissolution of drugs. The dissolution rate of Antofloxacin capsules using pregelatinized starch as an auxiliary material is lower than 30%, which is unacceptable in the formulation of Antofloxacin capsules

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antofloxacin capsule preparation and preparation method thereof
  • Antofloxacin capsule preparation and preparation method thereof
  • Antofloxacin capsule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Antofloxacin capsule preparation:

[0027]

[0028] Each capsule contains 100 mg of the active compound Antofloxacin.

[0029] Preparation method: Dry the above-mentioned various raw materials at 90±5°C, pass through 80-mesh sieve respectively, weigh according to the prescription amount, mix 110kg of Antofloxacin Hydrochloride, 90kg of Microcrystalline Cellulose and 10kg of Sodium Carboxymethyl Starch , add 5kg of starch slurry with a concentration of 3% by weight to make a suitable soft material, granulate with a 18-mesh sieve, dry at 70±5°C, add 3kg of magnesium stearate, granulate with an 18-mesh sieve, pack Put it in a hollow capsule. The prepared capsule preparation has better dissolution rate.

Embodiment 2

[0031] Antofloxacin capsule preparation:

[0032]

[0033] Each capsule contains 200mg of the active compound Antofloxacin.

[0034] Preparation method: dry the above raw and auxiliary materials at 90±5°C, pass through 80-mesh sieve respectively, weigh according to the prescription amount, mix 220kg of Antofloxacin Hydrochloride, 180kg of Microcrystalline Cellulose, and 20kg of Sodium Carboxymethyl Starch, and add the weight 10kg of starch slurry with a percentage concentration of 3%, made into a suitable soft material, granulated with a 18-mesh sieve, dried at 70±5°C, after adding 6kg of magnesium stearate, granulated with an 18-mesh sieve, and filled into hollow capsules Get it right away. The prepared capsule preparation has better dissolution rate.

Embodiment 3

[0036] Antofloxacin capsule preparation:

[0037]

[0038] Each capsule contains 300mg of the active compound Antofloxacin.

[0039] Preparation method: Dry the above raw and auxiliary materials at 90±5°C, pass through 80-mesh sieve respectively, weigh according to the prescription amount, mix 330kg of Antofloxacin hydrochloride, 180kg of pregelatinized starch, and 20kg of sodium carboxymethyl starch, and add the weight 10kg of starch slurry with a percentage concentration of 3%, made into a suitable soft material, granulated with a 18-mesh sieve, dried at 70±5°C, after adding 6kg of magnesium stearate, granulated with an 18-mesh sieve, and filled into hollow capsules Get it right away. The prepared capsule preparation has better dissolution rate.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an antofloxacin capsule preparation and a preparation method thereof. The capsule preparation comprises following raw and auxiliary materials in parts by weight: 100-500 parts of antofloxacin, 90-270 parts of filler, 10-30 parts of disintegrating agent, 5-15 parts of adhesive, and 3-9 parts of lubricant, wherein the filler is selected from one of microcrystalline cellulose or pregelatinized starch or both; the disintegrating agent is selected from one of sodium carboxymethyl starch or crospolyvinylpyrrolidone; the adhesive is selected from one of povidone or starch slurry with percentage concentration of 3% by weight; and the lubricant is magnesium stearate. The antofloxacin capsule preparation prepared from the raw and auxiliary materials in parts by weight has good dissolution rate, and can satisfy the requirement on the capsule preparation. The preparation method provided by the invention has the advantages of simple steps, stable preparation process and stable finished preparation, and meets the requirements of pharmaceutics.

Description

technical field [0001] The invention relates to a capsule preparation, in particular to an antofloxacin capsule preparation and a preparation method thereof. Background technique [0002] Antofloxacin (common name) is a quinolone antibacterial drug, and its chemical structural formula is: [0003] [0004] Its chemical name is: (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-8-amino-10-(4-methyl-1-piperazinyl)-7- Oxo-7H-pyrido[1,2,3-de]-[1,4]benzoxazine-6-carboxylic acid. [0005] Antofloxacin is a highly effective anti-infective drug. The main mechanism of action of this product is to achieve antibacterial effect by inhibiting the activity of bacterial DNA gyrase (bacterial topoisomerase II) and hindering the replication of bacterial DNA. [0006] Antibacterial test results show that Antofloxacin has antibacterial activity against most Gram-negative bacteria and Gram-positive bacteria. In vitro tests have shown antibacterial activity against Gram-positive bacteria, Gram-negati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/48A61K31/5383A61K47/36A61K47/32A61K47/38A61P31/04
Inventor 王祥常世忠魏科
Owner ANHUI GLOBAL PHARM CO LTD