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Rice prolamin bile acid adsorbent and preparation method thereof

A gliadin and bile acid technology, applied in plant zein, peptide/protein components, pharmaceutical formulations, etc., can solve the problems of toxic and side effects of bile acid adsorbents, and achieve prevention of coronary arteriosclerosis and cardiovascular disease. Effect

Inactive Publication Date: 2012-02-01
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The present invention aims to solve the technical problem of toxic and side effects of existing bile acid adsorbents, and further provides a rice prolamin bile acid adsorbent and a preparation method thereof

Method used

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  • Rice prolamin bile acid adsorbent and preparation method thereof
  • Rice prolamin bile acid adsorbent and preparation method thereof
  • Rice prolamin bile acid adsorbent and preparation method thereof

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Experimental program
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specific Embodiment approach 1

[0012] Embodiment 1: The rice prolamin bile acid adsorbent of this embodiment is gliadin with a molecular weight of 13.0 kDa and / or 16.0 kDa extracted from rice.

[0013] The prolamin in the rice prolamin bile acid adsorbent of this embodiment contains a large amount of hydrophobic amino acids and more sulfur-containing amino acids, is insoluble in water, and has a "resistant protein" (resistant protein) that is not easily digested and is similar to dietary fiber. protein)”, which can effectively absorb bile acids, hinder the enterohepatic circulation of bile acids, and promote the excretion of cholesterol, so as to effectively prevent coronary arteriosclerosis and prevent cardiovascular and other diseases.

specific Embodiment approach 2

[0014] Specific embodiment two: the preparation method of a kind of rice prolamin bile acid adsorbent of the present embodiment is carried out according to the following steps: 1, the volume ratio of methanol and ether is 1: 1~1.5 to measure methanol and ether and mix uniformly , to obtain a mixed solvent; 2. Pulverize the rice, then add the rice flour to the mixed solvent obtained in step 1, soak for 6h to 8h, and then filter to obtain the defatted rice flour; 3. Use the pH The phosphate buffer solution of 6.5 was leached three times, and then centrifuged to obtain a precipitate; 4. The precipitate obtained in step 3 was added to n-propanol with a mass percentage concentration of 55%, stirred at room temperature for 3h to 5h, and then After centrifugation, the supernatant is concentrated and then vacuum freeze-dried to obtain the rice prolamin bile acid adsorbent.

[0015] The prolamin in the rice prolamin bile acid adsorbent prepared in this embodiment contains a large amoun...

specific Embodiment approach 3

[0017] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that the mass volume ratio of rice flour and pH 6.5 phosphate buffer in step three is 1g: 8mL~15mL. Others are the same as in the first or second embodiment.

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Abstract

The invention discloses a rice prolamin bile acid adsorbent and a preparation method thereof, relating to a bile acid adsorbent and a preparation method thereof. The invention solves the technical problem that the traditional bile acid adsorbent has toxic side effects. The rice prolamin bile acid adsorbent is a prolamin which has the molecular weight of 13.0kDa and / or 16.0kDa and is extracted from rice. The preparation method comprises the following steps of: lixiviating and degreasing rice powder by a mixed solvent of methanol and diethyl ether, and then lixiviating three times by using phosphate buffer, lixiviating a precipitate obtained by centrifugation by using normal propyl alcohol with mass percentage concentration of 55% to obtain a supernatant liquor, and then condensing, freezing and drying the supernatant liquor to obtain the rice prolamin bile acid adsorbent. The rice prolamin bile acid adsorbent is insoluble in water and not easy to digest, can absorb bile acid, and can be used for preventing coronary sclerosis and cardiovascular disease.

Description

technical field [0001] The invention relates to a bile acid adsorbent and a preparation method thereof. Background technique [0002] Bile acid is the metabolite of cholesterol in the body. The use of bile acid adsorbent can promote the excretion of bile acid, inhibit the synthesis and absorption of cholesterol, and effectively reduce the cholesterol level in human serum and liver, thereby preventing coronary arteriosclerosis and cardiovascular disease. Most of the existing bile acid adsorbents are chemically synthesized substances, such as a bile acid adsorbent disclosed by CN1849649A, the invention name being the application of chitosan quaternary ammonium salt to adsorb bile acids, which includes iodide N-trimethyl Chitosan, chlorinated N-trimethyl chitosan and hydroxypropyl trimethyl chitosan; the publication number is CN1891303A and the invention name is the preparation method of the bile acid adsorbent of β-cyclodextrin polymer, disclosed A preparation method of an ad...

Claims

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Application Information

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IPC IPC(8): A61K38/16C07K14/425A61P9/10
Inventor 杨林
Owner HARBIN INST OF TECH
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