Preparation method of coumarin-modified hyaluronic acid graft micelle emulsifier

A technology of hyaluronic acid and coumarin, which is applied in the direction of chemical instruments and methods, cosmetic preparations, skin care preparations, etc., can solve the problems of limiting the chemical modification of hyaluronic acid and achieve excellent biocompatibility and biodegradability, good amphiphilicity, and the effect of broadening applications
CN102344501AInactive Publication Date: 2012-02-08JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2012-02-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of a coumarin-modified hyaluronic acid graft micelle emulsifier. The preparation method comprises the following steps that 1, carboxyl groups in a main chain of hyaluronic acid undergo an esterification reaction with hydroxy groups of 7-hydroxy-4-methylcoumarin in the presence of polyethylene glycol dimethyl ether as a phase transfer agent to produce a graft HA-g-Coumarin; and 2, the graft HA-g-Coumarin can carry out self-assembly to form nanometer micelles, wherein the nanometer micelles are dispersed steadily in an oil-water interface and are separated from the oil-water interface to form a stable emulsification disperse system. The preparation method of the coumarin-modified hyaluronic acid graft micelle emulsifier HA-g-Coumarin has the advantages of simple preparation technology, mild conditions, favorable function of absorbing ultraviolet rays having a certain wavelength, and good application prospects in the field of cosmetic-based sunburn prevention.
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Description

technical field

[0001] The invention relates to a preparation method of a coumarin-modified hyaluronic acid graft micelle emulsifier, in which a coumarin unit is introduced into the main chain of hyaluronic acid, and light-sensitive micelles are obtained through self-assembly. The invention can be used for sunscreen cosmetics and belongs to the field of polymer materials and photosensitive technology. Background technique

[0002] In recent years, the research and development of cosmetics has continuously made breakthrough progress. As a class of cosmetics, sunscreen lotion has more and more ingredients in its formula. The reason why sunscreen lotions can "sunscreen" is because the formula contains ultraviolet absorbers, which can absorb ultraviolet rays of a certain wavelength, thereby preventing ultraviolet rays from reaching the skin surface. At present, the UV absorbers used in sunscreen lotions mainly include: salicylates, p-aminobenzoates, benzophenones, methoxycinna...

Claims

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