Resolution method of levocetirizine chiral intermediates

A chiral intermediate, levocetirizine technology, applied in organic chemistry methods, chemical instruments and methods, separation of optically active compounds, etc., to achieve convenient post-processing, less waste, and high efficiency

Active Publication Date: 2015-07-15
浙江永合新材料科技有限公司
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the use of chiral ionic liquids for the resolution of levocetirizine chiral intermediates has broad application prospects, but there are no similar reports at home and abroad

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 287 g (1 mole) of 1-[(4-chlorophenyl)benzyl]piperazine and 3 moles of chiral tartrate ionic liquid into the reaction vessel, react at 50°C for 5 hours, and extract with 200 ml of toluene , the extracted reaction system was adjusted to pH=11-12 with 10% sodium hydroxide solution, then extracted three times with 200 ml of toluene, combined the toluene solution, dried over anhydrous sodium sulfate, filtered, concentrated, n-hexane crystallized to obtain white Crystalline powder product 52g, yield 36%, melting point: 94-96°C, specific rotation: [α] D ≤-21.5° (C1, toluene), optical purity: ≥99.0%, content: ≥99.0%.

Embodiment 2

[0026] Add 287 g (1 mole) of 1-[(4-chlorophenyl)benzyl]piperazine and 1 mole of chiral lactic acid ionic liquid into the reaction vessel, react at 10°C for 10 hours, and extract with 200 ml of toluene , the reaction system after extraction is adjusted to pH = 11-12 with 10% sodium hydroxide in mass percentage concentration, and then extracted three times with 200 ml of toluene, combined toluene solution, dried over anhydrous sodium sulfate, filtered, concentrated, n-hexane Alkanes were crystallized to obtain 49 grams of white crystalline powder product, yield 34%, melting point: 94-96°C, specific rotation: [α] D ≤-21.5° (C1, toluene), optical purity: ≥99.0%, content: ≥99.0%.

Embodiment 3

[0028] Add 287 g (1 mole) of 1-[(4-chlorophenyl)benzyl]piperazine and 2 moles of chiral mandelic acid ionic liquid into the reaction vessel, react at 60°C for 10 hours, and use 200 ml of toluene Extraction, the extracted reaction system is adjusted to pH = 11-12 with 10% sodium hydroxide solution by mass percentage, then extracted three times with 200 ml of toluene, combined toluene solution, dried over anhydrous sodium sulfate, filtered and concentrated , crystallized from n-hexane to obtain 53 grams of white crystalline powder product, yield 37%, melting point: 94-96°C, specific rotation: [α] D ≤-21.5° (C1, toluene), optical purity: ≥99.0%, content: ≥99.0%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
specific rotationaaaaaaaaaa
optical purityaaaaaaaaaa
Login to view more

Abstract

A resolution method of a levocetirizine chiral intermediates belongs to the technical field of fine organic chemical engineering. The method comprises the following specific steps: adding racemic 1-[(4-chlorophenyl)benzyl]piperazine and chiral ionic liquid in a reaction container to react at 10-100 DEG C for 1-10 hours, extracting with toluene for layering, adjusting the pH value of the aqueous phase with 10wt% of sodium hydroxide solution to 11-12, extracting with toluene again, and concentrating to crystallize after the post-treatment, thus obtaining the product. The chiral ionic liquid is used as the solvent and resolving agent, the technology is easy to operate, the efficiency is high, the yield of three wastes is low, the yield of the product is more than 34%, the melting range of the product is narrow, the melting point is 94-96 DEG C, the specific rotation [alpha] D is not more than -21.5 degrees (C1, toluene), the optical purity is not less than 99.0%, and the content is not less than 99.0%. The post-treatment is convenient, the ionic liquid can be used repeatedly and the resolution method is an economical, practical, green and environmentally friendly technology.

Description

technical field [0001] The invention relates to a method for resolving a chiral intermediate of levocetirizine by using a chiral ionic liquid. Background technique [0002] Levocetirizine hydrochloride is a third-generation antihistamine, a single optical isomer of the second-generation antihistamine cetirizine, and a selective H1 receptor antagonist, manufactured by SePracor of the United States and UCB of Belgium. The company jointly developed a new chiral drug for the treatment of seasonal allergic rhinitis, perennial rhinitis, adult and juvenile chronic idiopathic urticaria. The anti-allergic effect is fast, strong and long-lasting, stronger than all existing antihistamines, and has no central nervous system side effects such as sedation and drowsiness. It is a new generation of anti-allergic drugs. In 1982, UCB reported the condensation of 1-[(4-chlorophenyl)benzyl]piperazine and methyl chloroethoxyacetate, followed by hydrolysis and salt formation to obtain 2-[2-[4-[ ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07D295/073C07B57/00
CPCY02P20/54
Inventor 张正华裴文张文成吴国忠
Owner 浙江永合新材料科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap