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Solid oral preparation containing rosiglitazone and cetirizine hydrochloride

A technology of cetirizine hydrochloride and oral preparation, which is applied in the field of preparations containing rosiglitazone and cetirizine hydrochloride to achieve the effects of improving anti-allergic effect, reducing long-term risk and correcting allergic complications

Inactive Publication Date: 2012-03-28
CHENGDU HENGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Diabetic patients are usually accompanied by allergic complications. Although rosiglitazone drugs have a variety of formulations and preparations, there is no drug on the market that combines rosiglitazone and cetirizine hydrochloride to improve anti-allergic effects

Method used

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  • Solid oral preparation containing rosiglitazone and cetirizine hydrochloride
  • Solid oral preparation containing rosiglitazone and cetirizine hydrochloride
  • Solid oral preparation containing rosiglitazone and cetirizine hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: contain the solid oral preparation of rosiglitazone and cetirizine hydrochloride, it is made up of the component of following weight ratio:

[0043] Cetirizine Hydrochloride 10mg

[0044] Rosiglitazone 4mg

[0045] Appropriate amount of accessories.

[0046] Wherein, described auxiliary material is:

[0047]

[0048] The preparation method of the solid oral preparation containing rosiglitazone and cetirizine hydrochloride is:

[0049] 1. Pass 4 mg of the main drug rosiglitazone and 10 mg of cetirizine hydrochloride through a 100-mesh sieve, and 60 mg of lactose, 30 mg of microcrystalline cellulose and 15 mg of sodium carboxymethyl starch through a 80-mesh sieve, and mix well with the main drug ;

[0050] 2. Add 30 mg of 5% PVP ethanol solution, mix until dry and wet, and granulate with a 16-24 mesh sieve;

[0051] 3. Dry until the moisture content is below 5%, add 5 mg of magnesium stearate, mix evenly, pack into capsules to obtain the hard capsule...

Embodiment 2

[0053] A solid oral preparation containing rosiglitazone and cetirizine hydrochloride, which consists of components in the following weight ratios:

[0054] Cetirizine Hydrochloride 5mg

[0055] Rosiglitazone 12mg

[0056] Appropriate amount of accessories.

[0057] Wherein, described auxiliary material is:

[0058]

[0059] The preparation method of the solid oral preparation containing rosiglitazone and cetirizine hydrochloride is:

[0060] 1. Pass 12 mg of the main drug rosiglitazone and 5 mg of cetirizine hydrochloride through a 100-mesh sieve, 60 mg of lactose, 30 mg of microcrystalline cellulose and 15 mg of sodium carboxymethyl starch through a 80-mesh sieve, and mix well with the main drug ;

[0061] 2. Add 30 mg of 5% PVP ethanol solution, mix until dry and wet, and granulate with a 16-24 mesh sieve;

[0062] 3. Dry until the water content is below 5%, add 5 mg of magnesium stearate, mix evenly, pack into capsules to obtain the hard capsules of solid oral prep...

Embodiment 3

[0064] A solid oral preparation containing rosiglitazone and cetirizine hydrochloride, which consists of components in the following weight ratios:

[0065] Cetirizine Hydrochloride 20mg

[0066] Rosiglitazone 1mg

[0067] Appropriate amount of accessories.

[0068] Wherein, described auxiliary material is:

[0069]

[0070] The preparation method of the solid oral preparation containing rosiglitazone and cetirizine hydrochloride is:

[0071]1. Pass the main drug rosiglitazone 1 mg and cetirizine hydrochloride 20 mg through a 100-mesh sieve, the excipients lactose 60 mg, microcrystalline cellulose 30 mg and carboxymethyl starch sodium 15 mg through a 80-mesh sieve, and mix with the main drug evenly ;

[0072] 2. Add 30 mg of 5% PVP ethanol solution, mix until dry and wet, and granulate with a 16-24 mesh sieve;

[0073] 3. Dry until the moisture content is below 5%, add 5 mg of magnesium stearate, mix evenly, pack into capsules to obtain the hard capsules of solid oral ...

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Abstract

The invention discloses a solid oral preparation containing rosiglitazone and cetirizine hydrochloride. The solid oral preparation comprises 5 to 20mg of cetirizine hydrochloride and 1 to 12mg of rosiglitazone. The invention also discloses hard capsules, tablets, sustained-release coated tablets and pills made of the composition of rosiglitazone and cetirizine hydrochloride, as well as a preparation method thereof. The solid oral preparation has the advantages that: the rosiglitazone in the medicament can synergically improve the allergy resistance of cetirizine hydrochloride, is used for correcting allergic complication of diabetic patients, and is advantageous to reducing of forward risks of cardiovascular and cerebrovascular diseases of the diabetic patients.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and relates to a pharmaceutical composition, in particular to a preparation containing rosiglitazone and cetirizine hydrochloride. Background technique [0002] The main pathophysiological feature of type II diabetes is insulin resistance. Because rosiglitazone can effectively alleviate insulin resistance, improve insulin activity, have excellent hypoglycemic effect, and can produce synergistic effects with other diabetes drugs, and overcome the insulin toxicity of previous anti-diabetic drugs, it has been widely used clinically. use. [0003] Cetirizine hydrochloride is an antihistamine with high affinity and selectivity for HI receptors. The drug has a quick onset of action, good tolerance, and fewer adverse reactions. Its curative effect is better than that of terfenadine and astemizole. and other antihistamines. [0004] Diabetic patients are usually accompanied by allergic compli...

Claims

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Application Information

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IPC IPC(8): A61K31/495A61K31/4439A61P3/10A61P5/50A61P37/08A61K9/20A61K9/28A61K9/48
Inventor 朱德其
Owner CHENGDU HENGRUI PHARMA
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