Triphosadenine coenzyme insulin for injection and production technology thereof

A technology of adenosine triphosphate coenzyme and disodium adenosine triphosphate, which is applied in the field of injection of adenosine triphosphate coenzyme insulin and its preparation, can solve the problems of affecting the drug safety of patients, poor product stability, and long freeze-drying time, so as to achieve good product quality stability and formula components Reasonable, full-looking effect

Inactive Publication Date: 2012-04-04
HENAN FUREN HUAIQINGTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, excessive use of excipients not only increases the cost of the product, but more importantly, introduces unnecessary impurities into the product, thereby affecting the drug safety of patients
In addition, adenosine triphosphate coenzyme insulin free

Method used

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Embodiment Construction

[0021] The adenosine triphosphate coenzyme insulin for injection of the present invention is characterized by adenosine disodium triphosphate, coenzyme A, insulin, arginine hydrochloride, dextran 40, medicinal charcoal, and fresh water for injection as components. Each 1000ml adenosine triphosphate coenzyme insulin for injection contains 20g adenosine triphosphate disodium, 50,000 units of coenzyme A, 4000 units of insulin, 12g arginine hydrochloride, 20g dextran 40, 3g medicinal charcoal, and the rest are fresh water for injection.

[0022] The production process of the present invention includes: unscramble bottles→washing, drying, extinguishing bottles→washing, extinguishing, baking stoppers→preparation→filling→freeze drying→capping→light inspection→packing→warehousing.

[0023] 1. Washing, drying, and extinguishing bottles: the treated vials are put into the bottle washing machine, washed with water for injection by ultrasonic wave, washed with three gases and three water, and s...

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Abstract

The invention discloses a triphosadenine coenzyme insulin for injection and a production technology thereof. The triphosadenine coenzyme insulin for injection comprises disodium adenosine triphosphate, coenzyme A, insulin, argininehydrochloride, dextran 40, medicinal charcoal and fresh injection water. The production technology comprises steps of: dissolving dextran-40 with injection water, adding medicinal charcoal, boiling, cooling and adding argininehydrochloride in a liquid coolant to remove charcoal; adding disodium adenosine triphosphate into the charcoal removed solution, stirring and dissolving; adding coenzyme A and stirring for complete dissolving; adjusting a pH by sodium hydroxide; adding insulin hydrochloric acid aqueous solution and mixing; adjusting a pH by sodium hydroxide; adding injection water, preparing, filtering, loading and freeze-drying. The triphosadenine coenzyme insulin for injection prepared by the method of the invention has a more reasonable formula; prepared freeze-drying powder injection has plump appearance and can be rapidly dissolved in water; the solution is clarified and has good product stability.

Description

[0001] Technical field [0002] The invention belongs to the field of pharmaceutical preparations and provides an adenosine triphosphate coenzyme insulin for injection and a preparation method. Background technique [0003] Adenosine coenzyme insulin freeze-dried powder injection is a sterile freeze-dried powder injection made of adenosine disodium triphosphate, coenzyme A and insulin as the main drugs. Each bottle contains 20mg of adenosine triphosphate sodium, 50 U of coenzyme A, and 4 U of insulin. It is used to improve the symptoms of hepatitis, nephritis, liver cirrhosis, heart failure and other diseases. The sodium adenosine triphosphate in this product can improve the body's metabolism and participate in the metabolism of fat, protein, sugar, nucleic acid and nucleotides in the body. At the same time, it is the source of energy in the body; Coenzyme A is the coenzyme for the metabolism of acetyl reaction in the body. And protein metabolism plays an important role, which is...

Claims

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Application Information

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IPC IPC(8): A61K38/29A61K47/36A61P1/16A61P9/04A61P13/12A61K31/7076
Inventor 武东亮朱永杰白宗锋
Owner HENAN FUREN HUAIQINGTANG PHARMA
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