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Preparation method for gallnut sustained release gel

A technology of slow-release gel and gallnut, which is applied in the field of preparation of gallnut slow-release gel, to achieve the effects of inhibited release, good stability, and good extensibility

Inactive Publication Date: 2012-04-11
张爽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it has not been reported as a mature therapeutic drug in clinical practice.

Method used

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  • Preparation method for gallnut sustained release gel
  • Preparation method for gallnut sustained release gel
  • Preparation method for gallnut sustained release gel

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Embodiment Construction

[0036] The preparation method of Galla gall slow-release gel of the present invention, it comprises the steps:

[0037] The first step, the preparation of Galla gall freeze-dried powder:

[0038] Weigh 400 g of Galla gallica original drug, knock it open, wash it to remove insect scale, and dry it in a cool and ventilated place; use a low-temperature ultra-fine pulverizer (ZMD-40, Jiangsu, China) to carry out ultra-fine pulverization at 0 ° C, pass 140 Mesh sieve ， Add 1200ml of deionized water, shake at 150rpm at room temperature for 48 hours (using HYD constant temperature shaker, manufactured by Wuhan Scientific Instrument Factory, Chinese Academy of Sciences), filter, centrifuge, take the supernatant, put it in a -70°C freezer for 12 hours, take it out, and use The lyophilizer (Christ Alpha1-2, Germany) was operated at 0.6mbar for 288 hours to produce 150g of pale yellow lyophilized powder, which was refrigerated at 4°C for 30 minutes after 60Co irradiation;

[0039] ...

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Abstract

The present invention discloses a preparation method for gallnut sustained release gel. The method comprises: 1, weighing a gallnut raw drug, crushing, and screening with a sieve having 140 meshes; shaking with deionized water, filtering and centrifugating; taking supernatant, placing the supernatant in a freezer to carry out freezing, and then placing the frozen material in a freeze dryer to prepare into freeze dried powder; carrying out irradiation by 60Co, and carrying out cold preservation at a temperature of 4 DEG C to provide a spare use; 2, taking dichloromethane and triacetin to prepare into a mixed solvent, then adding a poly lactic acid-glycolic acid copolymer, and adding the prepared freeze dried powder after dissolving, wherein a ratio of the mixed solvent to the poly lactic acid-glycolic acid copolymer to the prepared freeze dried powder is 61:35:4; completely and uniformly stirring, and carrying out vortex shaking to prepare light yellow gallnut gel; preserving the lightyellow gallnut gel away from light for 24 hours at a temperature of 4 DEG C to obtain the finished product. The gallnut sustained release gel of the present invention has the following advantages that: the gallnut sustained release gel coagulates after contacting the water, such that periodontal membrane cells easily proliferate, and preferentially occupy the surface of the tooth root to form thenew adhesion; the gallotannin provides a broad-spectrum antibacterial effect for the common putative periodontal pathogens; the gallnut sustained release gel of the present invention is adopted as the drug for prevention and treatment of periodontal diseases and has the pharmaceutical value and the economic value of in-depth research and development.

Description

technical field [0001] The invention relates to a slow-release agent for treating periodontal disease, in particular to a preparation method of Galla gall slow-release gel. Background technique [0002] Periodontal disease is a common and frequently-occurring disease in the oral cavity, and it is one of the main causes of tooth loss in adults. The treatment of periodontal disease is generally divided into surgical treatment and non-surgical treatment. Non-surgical treatment is to eliminate plaque and other local irritating factors through mechanical curettage, supplemented by drug treatment to control and improve the treatment effect, and reduce recurrence. However, these treatment methods have not yet achieved satisfactory clinical efficacy, and the difference between basic treatment and drug adjuvant treatment in reducing the depth of periodontal pockets is not large (mostly within 1mm). When periodontal disease develops to a more serious stage, surgical treatment is req...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K47/34A61K9/06A61P1/02
Inventor 张爽王怡心张春喜程燕民慕秀囡王建华殷霄王鹏飞
Owner 张爽
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