Controllable vascularized artificial bone graft

Abstract

The invention discloses a controllable vascularized artificial bone graft in which a soft tissue window, a soft tissue window anchor bearing and a cell-stent complex match with each other to be integrated, wherein the cell-stent complex is made of porous medical alloy compounded with osteoblasts; and the soft tissue window and the soft tissue window anchor bearing are both made of medical absorbable materials, and the contact area of the artificial bone graft and a host soft tissue is controlled through adjusting the aperture of the soft tissue window so as to further realize the controllability of graft vascularization. The controllable vascularized artificial bone graft can realize the controllable vascularization after grafting, provides a good nutrition supply and metabolism environment for grafting cells, and simultaneously avoids local excessive vascular fibration of the graft, promotes osteogenic ability after artificial bone grafting, and effectively improves the clinical effect.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and specifically relates to a "soft tissue window" type controllable vascularized artificial bone graft, which is mainly used to control the degree of vascularization of the artificial bone graft when repairing bone defects, and ensure the activity of the artificial bone graft. Promote bone defect repair effect. Background technique [0002] Bone defect is a common clinical disease in orthopedics. At present, bone grafting is mainly used to treat bone defect and promote fracture healing. The use of autologous bone grafting to repair bone defects is still the "gold standard" of bone grafting. However, the amount of autogenous bone is limited, and the bone harvesting operation increases the trauma and pain of the patient, prolongs the operation time, and has complications such as infection, bleeding, and pain at the donor site. Bone graft substitutes such as allogeneic bone and heterogeneous...

AI Technical Summary

Problems solved by technology

However, although a satisfactory artificial bone construction effect has been achieved in the laboratory, artificial bone grafts that have survived well in vitro cannot obtain sufficient nutritional support in time after being implanted in the body, and a large number of cells die, making it difficult to exert osteogenic activity. So far, it has not been widely used in clinical practice, the main reasons are:

[0004] (1) Insufficient vascularization of bone grafts: good vascularization can ensure sufficient nutrient supply for transplanted cells, remove cell metabolites in time, and provide cells with a good metabolic environment

If the implanted bone substitute is insufficiently vascularized in vivo, it cannot provide sufficient blood supply to the inside of the scaffold, which will lead to the rapid death of bone seed cells in the scaffold due to lack of nutrients, which seriously reduces the osteoinductivity and osteoinductivity of the artificial bone. generative

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