Controllable vascularized artificial bone graft

An artificial bone and graft technology, applied in the field of biomedical engineering, can solve the problems of reducing the osteoinductivity and osteogenesis of artificial bone, difficult to exert osteogenic activity, and the death of bone seed cells, so as to avoid the risk of secondary surgery. , to ensure osteogenic activity and achieve controllable effects

An artificial bone and graft technology, applied in the field of biomedical engineering, can solve the problems of reducing the osteoinductivity and osteogenesis of artificial bone, difficult to exert osteogenic activity, and the death of bone seed cells, so as to avoid the risk of secondary surgery. , to ensure osteogenic activity and achieve controllable effects

CN102415922BInactive Publication Date: 2014-01-01FOURTH MILITARY MEDICAL UNIVERSITY
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  • Controllable vascularized artificial bone graft
  • Controllable vascularized artificial bone graft
  • Controllable vascularized artificial bone graft

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] Refer to attached Figure 1-3 As shown, this embodiment provides a controllable vascularized artificial bone graft, which consists of a soft tissue window 1, a soft tissue window anchor 2 and a cell-scaffold complex 3 that cooperate with each other to form a whole.

[0021] The soft tissue window 1 is made of medical absorbable material. In this embodiment, polycaprolactone is selected. The degradation cycle in vivo is 1-2 years. With a circular adjustable through hole D2, the diameter of the through hole D2 can be adjusted in the range of 2mm-10mm. By adjusting the size of the soft tissue window 1 aperture, the contact area between the artificial bone graft and the host soft tissue can be controlled, thereby achieving graft vascularization controllability.

[0022] The material of the soft tissue window anchor seat 2 is a medical absorbable material. The present embodiment also selects polycaprolactone, and adopts rapid prototyping technology to manufacture it to make...

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Abstract

The invention discloses a controllable vascularized artificial bone graft in which a soft tissue window, a soft tissue window anchor bearing and a cell-stent complex match with each other to be integrated, wherein the cell-stent complex is made of porous medical alloy compounded with osteoblasts; and the soft tissue window and the soft tissue window anchor bearing are both made of medical absorbable materials, and the contact area of the artificial bone graft and a host soft tissue is controlled through adjusting the aperture of the soft tissue window so as to further realize the controllability of graft vascularization. The controllable vascularized artificial bone graft can realize the controllable vascularization after grafting, provides a good nutrition supply and metabolism environment for grafting cells, and simultaneously avoids local excessive vascular fibration of the graft, promotes osteogenic ability after artificial bone grafting, and effectively improves the clinical effect.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and specifically relates to a "soft tissue window" type controllable vascularized artificial bone graft, which is mainly used to control the degree of vascularization of the artificial bone graft when repairing bone defects, and ensure the activity of the artificial bone graft. Promote bone defect repair effect. Background technique [0002] Bone defect is a common clinical disease in orthopedics. At present, bone grafting is mainly used to treat bone defect and promote fracture healing. The use of autologous bone grafting to repair bone defects is still the "gold standard" of bone grafting. However, the amount of autogenous bone is limited, and the bone harvesting operation increases the trauma and pain of the patient, prolongs the operation time, and has complications such as infection, bleeding, and pain at the donor site. Bone graft substitutes such as allogeneic bone and heterogeneous...

Claims

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Application Information

Patent Timeline
01 Jan 2014
Publication
CN102415922B
IPC
A61L27/56; A61L27/18; A61L27/58; A61F2/28; A61L27/06
Inventors
王林; 冯亚非