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Concentration method of pseudo-ginseng total saponin extracting solution

A technology of Panax notoginseng saponins and extraction method, which is applied in the field of concentration of Panax notoginseng saponins extract, can solve the problems of low pressure required, more permeable substances, and large loss of Panax notoginseng total saponins, and achieves the reduction of hydrolysis rate, High concentration effect

Active Publication Date: 2014-05-14
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the pore size of nanofiltration is larger than the pore size of reverse osmosis, the pressure required is smaller, and at the same time, more permeated substances are caused, and the total loss of Panax notoginseng saponins is greater

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Extraction and concentration of Panax notoginseng saponins

[0032] 1. Prepare Panax notoginseng extract:

[0033] Grind Panax notoginseng into coarse powder, extract 5 times with ethanol, use 2 times the amount of 50% ethanol each time, extract for 1 hour each time, combine the extracts, filter, recover the ethanol from the filtrate and concentrate under reduced pressure, and make every 1ml containing crude drug About 0.1g. Add 0.5% sodium chloride by volume to the concentrated solution, stir well, let stand for 12 hours, and filter. After the filtrate is degreased, pass through a macroporous adsorption resin column at a flow rate of 0.5 BV / h, wash with water, discard the washing solution, and sequentially use 40%, 50%, 60%, 70%, and 80% ethanol for gradient elution. Collect the eluate, and stop collecting the eluate when the alcohol concentration of the outlet eluate is equivalent to the inlet alcohol concentration. The eluent is pressurized through a 10...

Embodiment 2

[0047] Example 2: Extraction and concentration of Panax notoginseng saponins

[0048] 1. Grind Panax notoginseng into coarse powder, extract with ethanol 3 times, use 20 times the amount of 95% ethanol each time, extract for 5 hours each time, combine the extracts, filter, recover ethanol from the filtrate and concentrate under reduced pressure to make 1ml Contains crude drug about 1g. Add 1.5% sodium chloride by volume to the concentrated solution, stir well, let stand for 36 hours, and filter. After the filtrate was degreased, it was passed through a macroporous adsorption resin column at a flow rate of 15BV / h, washed with water, and the washing solution was discarded, followed by gradient elution with 40%, 50%, 60%, 70%, and 80% ethanol, and collected eluent. The eluent is pressurized through the neutral alumina column of 150% of the medicinal material amount (column internal pressure 100kg / cm 2 , the flow rate is 15BV / h), and the effluent is collected to obtain the Pana...

Embodiment 3

[0053] Example 3: Extraction and concentration of Panax notoginseng saponins

[0054] 1. Grind Panax notoginseng into coarse powder, extract with ethanol 4 times, each time with 8 times the amount of 60% ethanol, extract for 4 hours each time, combine the extracts, filter, recover the ethanol from the filtrate and concentrate under reduced pressure to make 1ml Contains crude drug about 0.2g. Add 1.0% sodium chloride by volume to the concentrated solution, stir well, let stand for 24 hours, and filter. After the filtrate is degreased, pass through a macroporous adsorption resin column at a flow rate of 10BV / h, wash with water, discard the washing solution, and successively use 40%, 50%, 60%, 70%, and 80% ethanol to ethanol gradient elution, Collect the eluate. The eluent is pressurized through the 100% neutral alumina column of the medicinal material amount (column internal pressure 30kg / cm 2 , the flow rate is 8BV / h), and the effluent is collected to obtain the Panax notogi...

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Abstract

The invention relates to a concentration method of a pseudo-ginseng total saponin extracting solution. A reverse osmosis process is mainly utilized to concentrate the pseudo-ginseng total saponin extracting solution. The concentration method provided by the invention has the advantages of favorable concentration effect and small loss.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to a method for concentrating a panax notoginseng saponin extract. Background technique [0002] The total saponins of Panax notoginseng are mostly obtained by ethanol extraction, and in the subsequent process, the recovery of ethanol is mostly carried out by heat reflux recovery of ethanol. [0003] The heat reflux method can be used to concentrate the extract of Panax notoginseng saponins until it has no alcohol smell, and finally dry it into powder. The hydrolysis rate is relatively high, and the large-scale production consumes a lot of energy. [0004] Patent application number 201010265373.3 (publication number is CN 101947250A), and the name of the invention is a new energy-saving process for extracting and purifying Panax notoginseng saponins. The eluent is pre-concentrated, and when concentrated to a volume of 10% of the eluent, it is directly sent to an evaporator to eva...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K36/258
Inventor 赵学伟黄宇声张栩颜刘冠萍李钊文陈小杰
Owner GUANGXI WUZHOU PHARMA GRP
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