Silicon dioxide base ultrasonic contrast medium/high intensity focused ultrasound (HIFU) synergist and preparation method thereof

A technology of ultrasound contrast agent and silicon dioxide, applied in the field of nanomaterials, can solve the problems of no relevant patents and no HIFU synergy, and achieve the effect of improving clinical applicability, excellent ultrasound contrast performance and high efficiency

Inactive Publication Date: 2012-05-09
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Recently, CN102068706A discloses a preparation method of silicon dioxide ultrasound imaging contrast material, which makes the surface of silicon dioxide microspheres linked with polyethylene glycol through surface modification, but it does not involve the effect of HIFU synergy
It can be seen that at present, there are no reports on the use of nano-biological materials to realize ultrasound contrast and enhance the efficiency of HIFU treatment at the same time, and there are no relevant patents to be found. Further research is needed.

Method used

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  • Silicon dioxide base ultrasonic contrast medium/high intensity focused ultrasound (HIFU) synergist and preparation method thereof
  • Silicon dioxide base ultrasonic contrast medium/high intensity focused ultrasound (HIFU) synergist and preparation method thereof
  • Silicon dioxide base ultrasonic contrast medium/high intensity focused ultrasound (HIFU) synergist and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Synthesis of Mesoporous SiO 2 Nanocapsules: 35.7mL ethanol, 5mL deionized water and 1.57mL ammonia water were stirred in 30°C water for 30min. Quickly add 3mL tetraethyl orthosilicate (TEOS) and stir for 1h. After that, add 2.5 mL of LTEOS and 1 mL of octadecyltrimethylsilane (C 18 TMS) to continue stirring for 1 h, and the obtained white precipitate was centrifuged. Prepare 0.6M Na 2 CO 3 Aqueous solution, add the above white precipitate and stir and etch at 80°C for 0.5h. The obtained precipitate was washed with water three times, dried and then calcined at 550° C. for 6 h.

Embodiment 2

[0070] Synthesis of ordered mesoporous SiO loaded with fluorescence 2 Nanocapsules: 35.7mL ethanol, 5mL deionized water and 1.57mL ammonia water were stirred in 30°C water for 30min. Quickly add 3mL tetraethyl orthosilicate (TEOS) and stir for 1h. Afterwards, add 2mLTEOS after reaction and then centrifuge and disperse in 14mL water; take 2mL of the above solution, 75mgCTAB, 15mL deionized water, 15mL ethanol and 0.275mL ammonia water and stir for 0.5h. Finally, 0.125mLTEOS and 150uL FITC-APTES were added and stirred at 30°C for 2h. Add 212 mg Na to 10 mL of water 2 CO 3 , add the centrifuged product, react at 50°C for 10 h, reflux in methanol to remove the surfactant CTAB, and obtain an ordered mesoporous hollow sphere carrier loaded with fluorescence.

Embodiment 3

[0072] The method of Example 2 was repeated, but the etching reaction was carried out at 70° C. for 2 h to obtain an ordered mesoporous bell-shaped carrier loaded with fluorescence.

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Abstract

The invention relates to a silicon dioxide base ultrasonic contrast medium/high intensity focused ultrasound (HIFU) synergist and a preparation method thereof. The silicon dioxide base ultrasonic contrast medium/HIFU synergist comprises a mesoporous silica nano capsule and a guest molecule, wherein the surface of the mesoporous silica nano capsule is modified by polyethylene glycol, and the guestmolecule is loaded in the mesoporous silica nano capsule and is used for HIFU synergism. In the synergist, the advantages of inorganic mesoporous silica nano particles and organic fluorocarbons are well combined. An organically and inorganically composite nano ultrasonic contrast medium/HIFU synergist can be provided. A diagnosis and treatment agent which is more stable, higher in biocompatibility, more excellent in ultrasonic contrast performance and obvious in the HIFU synergism is obtained.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to the technical field of medical nanobiological materials, in particular to a mesoporous silica nanocapsule material which can be used as both an ultrasound contrast agent and a HIFU synergist and a preparation method thereof. Background technique [0002] At present, the concept of non-invasive treatment has become a new direction of future medical development. Ultrasound therapy is a minimally invasive or non-invasive method of depositing sound energy into tissue. High Intensity Focused Ultrasound (HIFU), as the most representative non-invasive and non-radioactive new treatment mode, has achieved great success in clinical treatment of certain diseases (such as uterine fibroids). [0003] However, HIFU has not been widely used in the surgical treatment of tumors, especially malignant tumors (cancer). To solve this problem, two key points must be effectively resolved: one i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K9/51A61K47/04A61K47/34A61K45/00A61P35/00A61P41/00
Inventor 王霞陈航榕施剑林陈雨
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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