Separation-type water suspension medicament for treating dermatopathy

A technology for skin diseases and drugs, applied in the field of skin drugs, can solve the problems of particle instability and inability to ensure long-term storage of particle suspensions, and achieve the effects of reducing waste, ensuring suspension stability, and being easy to use

Inactive Publication Date: 2012-05-30
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] How to solve the problem of particle instability in microparticle suspensions has always been one of the problems that need to be solved in pharmacy, but whether by adding excipients or improving the particle structure, it is impossible to ensure long-term preservation of microparticle suspensions, especially for skin products. Suspensions are multi-use and are more likely to have the above problems

Method used

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  • Separation-type water suspension medicament for treating dermatopathy
  • Separation-type water suspension medicament for treating dermatopathy
  • Separation-type water suspension medicament for treating dermatopathy

Examples

Experimental program
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Effect test

preparation example Construction

[0028] 1. Preparation of drug particles for transdermal absorption

[0029] The capsules packed with the pharmaceutical microparticles obtained in Examples 1 to 10 are plant capsules, and the capsules are packed in aluminum foil blisters after packing.

Embodiment 1

[0031] Dissolve 1g of hydrocortisone in ethanol, filter, spray-dry the filtrate, micronize the particle size to 3μm, pass through a 200-mesh sieve for 3 times, mix well, sterilize, and pack in No. 3 capsules, each capsule has hydrogenation Cortisone 10mg. Electron microscope observation shows that the particles are spherical.

[0032] The process conditions are: the inlet temperature is 105°C, the outlet temperature is 68°C, the air flow rate is 90%, the inner diameter of the nozzle outlet is 0.1cm, the air flow rate of the nozzle is 800ml / min, and the injection speed is 50mL / h

Embodiment 2

[0034] Dissolve 1 g of triamcinolone acetonide acetate in ethanol, filter, spray-dry the filtrate, micronize it to make the particle size reach 3 μm, mix it with a 200-mesh sieve for 3 times, sterilize it, and pack it into No. 3 capsules. Each capsule has Triamcinolone acetonide acetate 1 mg. Electron microscope observation shows that the particles are spherical.

[0035] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 70°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and sample injection speed is 50mL / h.

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Abstract

A separation-type water suspension medicament for treating dermatopathy comprises an individually-packaged water-insoluble skin medicament with a D90 particle size of 0.1-10 microns, and individually-packaged water containing one or more than one skin pharmaceutic adjuvants; the individually-packaged water-insoluble skin medicament has a D90 particle size of 1-10 microns preferably; and the particle form is spherical or spheroidic.

Description

Technical field: [0001] The invention relates to a medicine for skin, which is composed of separately packaged water-insoluble skin medicine with a particle size of 0.1-10 μm, and separately packaged water containing one or more skin medicine auxiliary materials. Background technique: [0002] Skin inflammations such as eczema, allergic dermatitis, atopic dermatitis, and urticaria are caused by allergic reactions caused by certain allergens. [0003] In the skin drug delivery system, the skin is the main barrier for drugs to enter the body. Studies have found that only a few drugs have excellent skin permeability, and most drugs are not easy to pass through the effective and selective barrier of human skin. Drugs with higher solubility cross the epidermis more easily. In the treatment of skin diseases, the most common type of preparation is transdermal drug delivery, transdermal drug delivery system or transdermal drug delivery system (transdermal thrapeutic systems, transd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/56A61K31/57A61K31/573A61K31/58A61P17/00A61P17/08A61P37/08
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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