Nano-suspension of difficult-to-dissolve medicine as well as preparation method and application of nano-suspension
A technology for insoluble drugs and nanosuspensions, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of sedimentation, short storage time, and particle aggregation of nanosuspensions and other issues to achieve the effect of improving stability and extending storage time
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Example Embodiment
[0029] Example 1
[0030] The nano-suspension of the poorly soluble drug in this embodiment is composed of the following components: 10 parts of stabilizer, 40 parts of poorly soluble drug particles, and the rest is water;
[0031] Insoluble drugs include azithromycin, baicalin, sirolimus, valsartan and resveratrol;
[0032] The stabilizer includes a nonionic stabilizer and an ionic stabilizer, and the stabilizer includes a nonionic stabilizer and an ionic stabilizer in a mass ratio of 2-5:1;
[0033] The mass ratio of the nonionic stabilizer to the ionic stabilizer is 3:1;
[0034] The non-ionic stabilizer is composed of polyethylene glycol 200, Tween 20 and Span 80, and the mass ratio of polyethylene glycol 200, Tween 40 and Span 80 is 1:1:1;
[0035] The ionic stabilizer is composed of sodium lauryl sulfate and cetyl trimethyl quaternary ammonium salt, and the mass ratio of sodium lauryl sulfate and cetyl trimethyl quaternary ammonium salt is 4:1 .
[0036] For the above-mentioned ins...
Example Embodiment
[0041] Example 2
[0042] The present invention provides a nano-suspension of poorly soluble drugs, which is composed of the following components: 15 parts of stabilizer, 50 parts of poorly soluble drug particles, and the rest is water;
[0043] Insoluble drugs include azithromycin, baicalin, sirolimus, valsartan and resveratrol;
[0044] The stabilizer includes a nonionic stabilizer and an ionic stabilizer, and the mass ratio of the nonionic stabilizer to the ionic stabilizer is 5:1;
[0045] The stabilizer includes a nonionic stabilizer and an ionic stabilizer in a mass ratio of 5:1;
[0046] The non-ionic stabilizer is composed of polyethylene glycol 200, Tween 20 and Span 80, and the mass ratio of polyethylene glycol 200, Tween 40 and Span 80 is 3:1:1;
[0047] The ionic stabilizer is composed of sodium lauryl sulfate and cetyl trimethyl quaternary ammonium salt, and the mass ratio of sodium lauryl sulfate and cetyl trimethyl quaternary ammonium salt is 1:1 .
[0048] The preparation...
Example Embodiment
[0049] Example 3
[0050] On the basis of Example 1, the concentration of the poorly soluble drug particles is 6-8%, preferably 8%, which is coordinated with nonionic surfactants and ionic surfactants to further improve the suspension of drug particles. Stability in liquid.
[0051] The preparation method of the nanosuspension of the poorly soluble drug of Example 3 is the same as that of Example 1.
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