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Phenobarbital molecular imprinted polymer and application of phenobarbital molecular imprinted polymer serving as solid-phase extractant

A technology of phenobarbital and molecular imprinting, which is applied in the fields of analytical chemistry and material science, can solve difficult extraction and separation problems, achieve broad application prospects, improve separation precision, and be easy to operate

Inactive Publication Date: 2012-05-30
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of difficult extraction and separation of barbiturates in complex samples in the prior art, and propose a phenobarbital molecularly imprinted polymer and its application as a solid phase extraction agent

Method used

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  • Phenobarbital molecular imprinted polymer and application of phenobarbital molecular imprinted polymer serving as solid-phase extractant

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Embodiment

[0026] Phenobarbital molecularly imprinted polymer, its specific preparation steps are:

[0027] 1) Put 74.5mg (0.5mmol) of phenobarbital (0.5mmol) and 344mg acrylamide (4mmol) into a 50mL test tube, then dissolve it with 25.5ml acetonitrile and mix well, seal it and put it in the refrigerator for self-polymerization for 24 hours, the temperature of the refrigerator is at 4°C Then add 1280μL (4mmol) trimethylolpropane trimethacrylate and 6.56mg azobisisobutyronitrile (0.04mmol) at room temperature, mix well and pass nitrogen gas for 10min, then put it into the UV light box, Under 4°C, use ultraviolet light with a wavelength of 260nm to initiate polymerization for 24 hours to obtain spherical particle polymers;

[0028] 2) Soak the spherical particle polymer obtained in step 1) with organic solvent methanol / acetic acid and stir for 2h, the template molecules in the spherical particle polymer are dissolved in the organic solvent methanol / acetic acid, and then centrifuged to remo...

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Abstract

The invention relates to a phenobarbital molecular imprinted polymer and the application of the phenobarbital molecular imprinted polymer serving as solid-phase extractant, which belong to the technical field of analytical chemistry and material science. The preparation method includes firstly, mixing phenobarbital serving as a template molecule with functional monomers in solvent and storing the uniform mixture for 24 hours at the temperature below 4 DGE C to form pre-polymer; secondly, adding crosslinking agent and initiating agent at the normal temperature and using ultraviolet light 260nm in wavelength for initiated polymerization for 24 hours to obtain a spherical particle polymer; and thirdly, using organic solvent methanol / acetic acid for soaking to remove impurities and obtaining the phenobarbital molecular imprinted polymer after vacuum drying. The preparation method of the phenobarbital molecular imprinted polymer is simple, convenient and rapid, and well absorptive to structurally similar objects such as phenobarbital, barbital and pentobarbital. The solid-phase extraction method is simple in operation, selectively absorbs target objects, is capable of effectively removing matrix impurities, improving separation precision and reducing the limit of detection, and is applicable to extraction and separation of barbital drugs in biological samples in the field of forensic science.

Description

technical field [0001] The invention relates to a phenobarbital molecularly imprinted polymer and its application as a solid-phase extraction agent, belonging to the technical fields of analytical chemistry and material science. Background technique [0002] Phenobarbital belongs to barbiturate hypnotic and sedative drugs, and is often encountered in criminal toxicology analysis. , hair or organ tissue) is still a hot and difficult research topic for forensic toxicology analysts. [0003] The molecular imprinting technique developed in recent years provides new ideas and new ways for the extraction and separation of barbiturates in forensic toxicology analysis. Molecularly imprinted polymers (MIPs) have three major characteristics: predestination, recognition, and practicability. They have a "memory" effect on the spatial structure of target molecules, and can highly selectively identify imprinted molecules in complex samples; and MIPs can be used repeatedly. And it has go...

Claims

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Application Information

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IPC IPC(8): C08F265/10C08F2/44C08J9/26B01J20/285B01J20/30B01D15/20
Inventor 常靖何瑞琼朱军张蕾萍孟子晖栾玉静于忠山何毅
Owner INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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