Instant florfenicol and preparation method thereof

Abstract

The invention discloses instant florfenicol which comprises florfenicol and carbamide, wherein carbamide accounts for 18% to 90% of the total weight of the instant florfenicol. The invention also provides a preparation method for the instant florfenicol. The invention has the following advantages: the instant florfenicol is used for treating infection at every part of livestock or poultry or an aquatic animal caused by bacteria, e.g., respiratory and intestinal infection of poultry, bacterial respiratory diseases, intestinal infection, postpartum syndrome and the like of pigs, cattle, horses, etc., and infection of fishes caused by Pasteurella multocida, Staphylococcus aureus and other Gram-negative bacteria; the instant florfenicol has a very fast dissolving speed and does not produce flocculent precipitates; the preparation method for the instant florfenicol is simple, uses a few accessories, needs a small amount of equipment and can satisfy the need that livestock and poultry take medicines through drinking of water.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to an instant florfenicol and a preparation method thereof. Background technique [0002] Florfenicol, also known as florfenicol, is a monofluorinated derivative of thiamphenicol, and its chemical name is [R-(R*, R*)]-2,2-dichloro-N-[1- (fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide. Florfenicol is the third-generation product of chloramphenicol, which is a new broad-spectrum antibiotic for veterinary medicine. Florfenicol was first launched in Japan in 1990. In 1993, Norway approved the drug to treat salmon furunculosis. In 1995, France, the United Kingdom, Austria, Mexico and Spain approved it to treat bovine respiratory bacterial diseases. In Japan and Mexico, it is also approved to be used as a feed additive for pigs to prevent and treat bacterial diseases in pigs. my country has now passed the approval of the drug, and "Chinese Veterinary Pharmacopoeia" (2010 edition...

AI Technical Summary

Problems solved by technology

However, the production of a florfenicol prodrug requires about a variety of chemical raw materials, production equipment including reaction kettles, condensers, high-level storage tanks, recovery tanks, waste liquid treatment equipment, and a complex production process ; Need to add a co-solvent before use, otherwise, the prepared aqueous solution is prone to flocculent precipitation

Therefore, although florfenicol prodrug can improve its water solubility, its process is complicated and the production cost is too high

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