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Blood vessel stent and preparation method thereof

A vascular stent and braided tube technology, applied in the field of vascular stents, can solve the problems of disrupted protein distribution, compliance mismatch, blood coagulation, etc., and achieve the effect of successful transplantation

Active Publication Date: 2012-06-20
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This difference in expansion and contraction will cause the two to produce different propagation rates of blood pressure waves at the suture, causing wave reflection and eddy currents, which in turn will lead to blood coagulation and cell proliferation; Stress concentration occurs at the suture, and vascular endothelial cells subjected to excessive stress will release an enzyme that promotes the proliferation of smooth muscle cells, resulting in sharp thickening and hyperplasia of blood vessels; at the same time, the mismatch of compliance will also disrupt the uniform distribution of proteins in blood vessels , so that it forms a concentration at the suture
The above consequences caused by compliance mismatch will directly lead to the failure of vascular grafts, threatening the life safety of patients

Method used

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  • Blood vessel stent and preparation method thereof
  • Blood vessel stent and preparation method thereof
  • Blood vessel stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]This embodiment provides a small-diameter vascular stent that can improve compliance, and the preparation steps are as follows:

[0042] 1) Put 1 kg of cocoon shell into 50 liters of neutral soap solution with a mass concentration of 0.5%, and treat it at 98-100°C for 2 hours to degumming the cocoon shell, and obtain pure silk fibroin (silk fibroin) after fully washing . The dried pure silk fibroin is dissolved in 5 liters of 9.3 mol / liter lithium bromide aqueous solution with stirring at 65±2° C. to form a silk fibroin mixed solution.

[0043] 2) Using a cellulose membrane as a dialysis material, dialyzing the obtained silk fibroin mixed solution with deionized water to remove impurities such as lithium bromide to obtain a pure silk fibroin solution, adjusting the mass concentration of the silk fibroin solution to 3%.

[0044] 3) Pour the silk fibroin solution into a polyethylene container, dry it at room temperature to obtain a silk fibroin film, and pulverize it to o...

Embodiment 2

[0054] 1) Put 1 kg of raw silk into 30 liters of 0.2% sodium carbonate aqueous solution, treat it at 98-100° C. for 2 hours, degumming the raw silk, and obtain pure silk fibroin (ie silk fibroin) after fully washing. The dried pure silk fibroin is dissolved with 8 liters of calcium chloride, water and ethanol solution with a molar ratio of 1:8:2 at 75±5° C. to form a silk fibroin mixed solution.

[0055] 2) Using a cellulose membrane as a dialysis material, dialyzing the obtained silk fibroin mixed solution with deionized water to remove impurities such as calcium chloride to obtain a pure silk fibroin solution, adjusting the mass concentration of the silk fibroin solution to 6%.

[0056] 3) Pour the silk fibroin solution into a polyethylene container, dry it at room temperature to obtain a silk fibroin film, and pulverize it to obtain a silk fibroin powder.

[0057] 4) Weigh 0.5 g of silk fibroin powder with an electronic balance, weigh 2 g of PLCL (LA: CL = 50: 50), dissolve...

Embodiment 3

[0065] 1) Put 200 grams of cocoon shells into 10 liters of aqueous sodium carbonate solution with a mass concentration of 0.3%, and treat them at 98-100° C. for 2 hours to degumming the cocoon shells, and obtain pure silk fibroin (ie silk fibroin) after fully washing. The dried pure silk fibroin is dissolved with 100 ml of 9.3 mol / liter lithium bromide aqueous solution under stirring at 65±2° C. to form a silk fibroin mixed solution.

[0066] 2) Using a cellulose membrane as a dialysis material, dialyze the obtained silk fibroin mixed solution with deionized water to remove impurities such as lithium bromide to obtain a pure silk fibroin solution, and adjust the mass concentration of the silk fibroin solution to 9%.

[0067] 3) Pour the silk fibroin solution into a polyethylene container, dry it at room temperature to obtain a silk fibroin film, and pulverize it to obtain a silk fibroin powder.

[0068] 4) Weigh 0.5 grams of silk fibroin powder with an electronic balance, weig...

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Abstract

The invention discloses a blood vessel stent, which comprises an inner layer, a middle layer and an outer layer. The inner layer is made of an electrostatic spinning screen blended by silk fibroin and PLCL (caprolactone), the middle layer is made of an electrostatic spinning screen blended by silk fibroin and PLCL and is sleeved outside the inner layer, the outer layer is a silk fibroin braided hose and sleeved outside the middle layer, and the inner layer, the middle layer and the outer layer are connected in a stitching manner so that intermittent annular spaces are respectively formed between the inner layer and the middle layer and between the middle layer and the outer layer. The blood vessel stent has fine biological compatibility, can be used for repairing of small-bore blood vessels, and can be matched with blood vessels of hosts due to the compliance thereof.

Description

technical field [0001] The invention relates to a blood vessel stent, which belongs to the field of biomedical materials. Background technique [0002] Vascular diseases seriously endanger human health. Every year, tens of thousands of people around the world suffer from vascular diseases due to various reasons such as vascular aging, damage, and disease. Vascular defect repair, especially the repair of small-diameter vessels (inner diameter <6 mm) has always been one of the clinical difficulties. [0003] Embolism is the main cause of failure after small-bore vascular grafts. There are many reasons for embolism, and the mismatch between artificial blood vessel and host blood vessel compliance after implantation is one of the main causes of thrombosis and intimal hyperplasia in small-caliber artificial blood vessels. [0004] Compliance (generally refers to radial compliance, which can be calculated by the formula for intuitive characterization, where D 2 and D 1 Re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61F2/90A61F2/06
Inventor 赵荟菁吕强李明忠
Owner SUZHOU UNIV
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