Glimepiride orally disintegrating medicine composition
The technology of oral disintegration and oral disintegration tablet is applied in the field of oral disintegrating pharmaceutical composition of glimepiride and its preparation, which can solve the problems of low dissolution rate, poor water solubility and the like, achieve high bioavailability, stable quality, Simple and easy method
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Embodiment 1
[0084] The orally disintegrating pharmaceutical composition of glimepiride described in every 1000 tablets is composed of:
[0085] Glimepiride 2g
[0086] Polyacrylic resin S100 6g
[0087] 95% ethanol 60ml
[0088] Mannitol 40g
[0089] Ethylcellulose 5g
[0090] Croscarmellose Sodium 8g
[0091] 10% pregelatinized starch solution appropriate amount
[0092] Croscarmellose Sodium 4g
[0094] Preparation Process:
[0095] 1) Disperse polyacrylic acid resin S100 in 95% ethanol of prescription quantity;
[0096] 2) Dissolve the prescribed amount of glimepiride in step 1), and stir for 30 minutes to completely dissolve;
[0097] 3) Rotate the sample in step 2) at 60±2°C for about 3 hours to obtain the inclusion compound of glimepiride;
[0098] 4) Measure the content of glimepiride inclusion compound, and convert the dosage of glimepiride inclusion compound;
[0099] 5) Weigh the inclusion compound of glimepiride, mannitol, ethyl cellulo...
Embodiment 2
[0107] The orally disintegrating pharmaceutical composition of glimepiride described in every 1000 tablets is composed of:
[0108] Glimepiride 4g
[0109] Polyacrylic resin S100 12g
[0110] 95% ethanol 120ml
[0111] Mannitol 40g
[0112] Ethylcellulose 5g
[0113] Croscarmellose Sodium 8g
[0114] 10% pregelatinized starch solution appropriate amount
[0115] Croscarmellose Sodium 4g
[0117] Preparation process: with embodiment 1.
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