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Medical slow release material and preparation method thereof

A slow-release material and technology of slow-release microspheres, applied in medical science, surgery, etc., can solve problems such as inability to provide efficient and safe slow-release systems, restrict product market expansion and application, and low bioavailability, and achieve good results. Biocompatibility, good plasticity, high safety effect

Active Publication Date: 2012-07-11
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the process of treating various orthopedic diseases, some drugs or factors need to be used in combination, but these drugs or factors have a short half-life and are quickly diluted and metabolized when applied locally, and their bioavailability is extremely low; especially some growth factors, hormones Protein-based drugs are expensive to produce and unbearable for patients, which restricts the market expansion and application of such products
However, the existing technology cannot provide an efficient, safe and minimally invasive sustained release system

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] The preparation method of the temperature-sensitive microsphere-loaded injectable medical slow-release material of the present invention mainly includes the following steps:

[0031] 1) Preparation of pulsed sustained-release microspheres: first prepare microspheres loaded with drugs or factors with different release periods, and then mix microspheres with different release periods in a certain proportion to form the same or different "Pulse sustained-release microspheres" for alternate release of drugs;

[0032] 2) Preparation of temperature-sensitive polymer solution: at room temperature, dissolve the temperature-sensitive polymer with physiological saline or phosphate buffer until completely dissolved;

[0033] 3) Mixing: Mix the "pulse slow-release microspheres" prepared in step 1 with the solution prepared in step 2, stir evenly, and prepare a mixed solution of microspheres and polymers.

[0034] The preparation method may further include step 4: curing, specifica...

Embodiment 1

[0043] The method for preparing and using the injectable slow-release material loaded with thermosensitive microspheres specifically comprises the following steps:

[0044] 1) Five types of microspheres with release periods of 1 week, 2 weeks, 4 weeks, 8 weeks and 12 weeks were prepared, and then mixed together in a ratio of 1:1:1:1:1 to form an alternate release " Pulse-type slow-release microspheres", the drug contained in the microspheres with a release period of 1 week and 2 weeks is gentamicin, accounting for 3% of the total mass of the microspheres, which can play an antibacterial and anti-inflammatory role at the wound site; release The drug factor rhBMP-2 contained in three kinds of microspheres with cycle of 4 weeks, 8 weeks and 12 weeks accounted for 0.005% of the total mass of microspheres.

[0045] 2) Dissolve PNIPAAm-g-Ch in phosphate buffer at room temperature until it is completely dissolved to prepare a 5% PNIPAAm-g-Ch solution;

[0046] 3) Mix the "pulse slow...

Embodiment 2

[0050] The method for preparing and using the injectable slow-release material loaded with thermosensitive microspheres specifically comprises the following steps:

[0051] 1) Five types of microspheres with release periods of 1 week, 2 weeks, 4 weeks, 8 weeks and 12 weeks were prepared, and then mixed together in a ratio of 2:1:1:1:1 to form alternate release " Pulse-type slow-release microspheres”, the drugs contained in the microspheres with a release period of 1 week and 2 weeks are vancomycin and gentamicin, respectively accounting for 3% of the total mass of the microspheres, which can treat severe infection in bone defects The site plays the role of antibacterial and anti-inflammatory; the drug factor rhBMP-2 contained in three kinds of microspheres with the release period of 4 weeks, 8 weeks and 12 weeks accounts for 0.008% of the total mass of the microspheres.

[0052] 2) Dissolve PNIPAAm-g-HA in phosphate buffer solution at room temperature until it is completely di...

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Abstract

The invention relates to an injectable medical slow release material which is mainly formed by the mixing of pulse type releasing microspheres carrying drugs and a temperature sensitive polymer solution. The preparation method mainly comprises the steps of preparing the pulse type releasing microspheres carrying drugs; preparing the temperature sensitive polymer solution; and mixing the pulse type releasing microspheres carrying drugs with the temperature sensitive polymer solution, and stirring the mixture to be uniform to form a mixed solution. According to the invention, carrying factors or microspheres of drugs are uniformly dispersed in the solution of the temperature sensitive injectable carrier, and after the solution is injected to a treatment position, the material is solidified quickly and then degrades slowly to release drugs or factors, so as to prolong the active time of the factors in the body, and improve the controllability on factor release speed and factor release cycle, thereby realizing the combination of release of same or different drugs in desired locations and different time slots alternatively and the manner of minimally invasive treatments.

Description

technical field [0001] The invention belongs to the field of bioactive materials, in particular to a temperature-sensitive injectable slow-release material loaded with microspheres and a preparation and use method thereof. Background technique [0002] In my country, there are 3 to 4 million patients with bone injuries caused by traffic accidents and production safety accidents every year. Coupled with orthopedic diseases such as bone tumors, bone tuberculosis, and avascular necrosis of the femoral head, there are many patients with bone defects. Therefore, bone defect has become a serious disease and social problem affecting people's healthy life. With the aging of my country's population, the improvement of people's health awareness and consumption ability, and the improvement of the national medical security system, the market demand for bone repair materials in my country has increased sharply. Autologous bone is an ideal material for bone defect repair, but the process ...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/16A61L31/04A61L31/06
Inventor 谭荣伟佘振定王明波刘伟强张文强李丽花
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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